Results 261 to 270 of about 9,201,564 (391)

Huntingtin Lowering Strategies for Disease Modification in Huntington’s Disease

Neuron, 2019
S. Tabrizi, R. Ghosh, B. Leavitt
semanticscholar   +1 more source

TSP50 in Neural Stem Cells Regulates Aging‐Related Cognitive Decline and Neuroinflammation by Altering the Gut Microbiota

Aging Cell, EarlyView.
TSP50 expression declines in the hippocampus of aged humans and mice. TSP50 deficiency in NSCs accelerates mouse aging, causing cognitive impairments and neuroinflammation. Restoring gut microbiota via FMT and TSP50 overexpression alleviates these phenotypes. Our study shows TSP50's critical role in aging and gut microbiota as a key mediator.
Xiaoli Li, Yuecong Chen, Zhuoyi Gao, Xiaoling Liu, Zhenbo Song, Feng Gao, Shuyue Wang, Chunlei Yu, Luguo Sun, Yanxin Huang, Lihua Zheng, Guannan Wang, Ying Sun, Jiawei Li, Xiaoguang Yang, Yongli Bao   +15 more
wiley   +1 more source

Pediatric Huntington Disease Brains Have Distinct Morphologic and Metabolic Traits: the RAREST-JHD Study. [PDF]

Mov Disord Clin Pract
Caligiuri ME, Tinelli E, Vizza P, Giancaterino G, Cicone F, Cascini GL, Sabatini U, Squitieri F.   +7 more
europepmc   +1 more source

Pearls & Oy-sters: Epilepsy Is a Key Feature of Pediatric-Onset Huntington Disease. [PDF]

Neurology, 2023
Lammert DB, Bang J, Stafstrom CE.
europepmc   +1 more source

Pitfalls in the Use of Voxel-Based Morphometry as a Biomarker: Examples from Huntington Disease [PDF]

, 2009
Susie M.D. Henley, Gerard R. Ridgway, Rachael I. Scahill, Stefan Klöppel, Sarah J. Tabrizi, Nick C. Fox, Jan Kassubek   +6 more
openalex   +1 more source

From Abstinence to Assistance: Antinatalism's Unexpected Endorsement of the Principle of Procreative Beneficence

Bioethics, EarlyView.
ABSTRACT This essay begins from the point that developments in antinatalism, or the view that it is wrong to bear children, place legitimate pressures on prospective parents to seriously consider the harms of bringing their prospective children into existence.
Marcus T. L. Teo
wiley   +1 more source

Huntington Disease Health Related Quality of Life, Function and Well Being: The Patient's Perspective. [PDF]

Neurol Ther
Pérez-Pérez J, García-López S, Valle TF, Painous C, Querol-Pascual MR, Ruiz PJG, Diago EB, Cubo Delgado E, Pastor BV, Villaplana MCP, Santana IM, Blázquez Estrada M, Garride MC, Mir P, Álvarez C, Maurino J, de Prado A, López-Sendón JL.   +17 more
europepmc   +1 more source

Intraneuronal polyglutamine aggregates are present in diverse CNS locations in Huntington disease

, 2007
Emily Herndon, Christa L. Hladik, Ping Shang, Dennis K. Burns, Charles L. White   +4 more
openalex   +1 more source

Cognitive change in patients with Huntington disease on the Repeatable Battery for the Assessment of Neuropsychological Status [PDF]

, 2009
Leigh J. Beglinger, Karen Duff, Jessica Allison, Danielle Theriault, Justin J. F. O’Rourke, Anne Leserman, Jane S. Paulsen   +6 more
openalex   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source