Results 21 to 30 of about 9,130,139 (414)

MicroRNA-124 slows down the progression of Huntington′s disease by promoting neurogenesis in the striatum

Neural Regeneration Research, 2015
MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington′s disease mouse models and patients is decreased.
Tian Liu, Wooseok Im, Inhee Mook-Jung, Manho Kim   +3 more
doaj   +1 more source

Anesthetic management of a patient with Huntington's chorea -A case report- [PDF]

Korean Journal of Anesthesiology, 2013
Huntington's chorea is a rare hereditary disorder of the nervous system. It is inherited as an autosomal dominant disorder and is characterized by progressive chorea, dementia and psychiatric disturbances.
Jong-Man Kang, Jun-Young Chung, Jin Hee Han, Yung-Suk Kim, Bong Jae Lee, Jae-Woo Yi   +5 more
doaj   +1 more source

Systemic Air Embolism Associated with Pleural Pigtail Chest Tube Insertion

Case Reports in Pulmonology, 2016
Pleural pigtail catheter placement is associated with many complications including pneumothorax, hemorrhage, and chest pain. Air embolism is a known but rare complication of pleural pigtail catheter insertion and has a high risk of occurrence with ...
Emad Alkhankan, Ahmad Nusair, Rida Mazagri, Mohammed Al-Ourani   +3 more
doaj   +1 more source

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity ...
S. Frank, C. Testa, D. Stamler, E. Kayson, C. Davis, M. Edmondson, S. Kinel, B. Leavitt, D. Oakes, C. O’Neill, C. Vaughan, J. Goldstein, M. Herzog, Victoria Snively, J. Whaley, Cynthia Wong, G. Suter, J. Jankovic, J. Jimenez-shahed, C. Hunter, D. Claassen, Olivia C. Roman, V. Sung, J. Smith, Sarah C. Janicki, R. Clouse, M. Saint-Hilaire, A. Hohler, Denyse Turpin, Raymond James, Ramon Rodriguez, Kyle Rizer, K. Anderson, Hope Heller, A. Carlson, S. Criswell, B. Racette, Frédy J. Revilla, F. Nucifora, R. Margolis, Maryjane Ong, T. Mendis, Neila Mendis, C. Singer, M. Quesada, Jane S. Paulsen, T. Brashers-Krug, Amanda Miller, J. Kerr, R. Dubinsky, C. Gray, S. Factor, Elaine Sperin, E. Molho, M. Eglow, S. Evans, R. Kumar, Christina Reeves, A. Samii, S. Chouinard, M. Beland, B. Scott, Patrick Hickey, Sherali Esmail, W. Fung, Clare A. Gibbons, Li Qi, A. Colcher, Cory Hackmyer, A. McGarry, K. Klos, Mark Gudesblatt, Lori Fafard, Laura Graffitti, Daniel Schneider, R. Dhall, J. Wojcieszek, K. LaFaver, A. Duker, Erin Neefus, H. Wilson-Pérez, David R. Shprecher, P. Wall, K. Blindauer, Lynn Wheeler, J. Boyd, Emily Houston, Eric S. Farbman, P. Agarwal, S. Eberly, A. Watts, P. Tariot, A. Feigin, S. Evans, C. Beck, C. Orme, Jon Edicola, E. Christopher   +97 more
semanticscholar   +1 more source

Brain Growth in Children at Risk for Huntington Disease

Pediatric Neurology Briefs, 2012
Researchers at the University of Iowa and Washington University, St Louis, MO, studied the effect of the mutant Huntington gene (mHTT) on measures of growth in children at risk for Huntington disease (HD).
J Gordon Millichap
doaj   +1 more source

Huntington disease: a single-gene degenerative disorder of the striatum

Dialogues in Clinical Neuroscience, 2016
Huntington disease (HD) is an autosomal dominant, neurodegenerative disorder with a primary etiology of striatal pathology. The Huntingtin gene (HTT) has a unique feature of a DNA trinucleotide (triplet) repeat, with repeat length ranging from 10 to 35 ...
P. Nopoulos
semanticscholar   +1 more source

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

Nature Communications, 2016
The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin ...
A. Benraiss, Su Wang, Stephanie Herrlinger, Xiaojie Li, Devin Chandler-Militello, Joseph Mauceri, Hayley Burm, Michael J Toner, M. Osipovitch, Qiwu Jim Xu, Fengfei Ding, Fushun Wang, Ning Kang, Jian Kang, Paul C. P. Curtin, D. Brunner, M. Windrem, I. Muñoz-Sanjuán, M. Nedergaard, S. Goldman   +19 more
semanticscholar   +1 more source

Huntington’s disease alters human neurodevelopment

Science, 2020
Neural progenitors disrupted Symptoms of Huntington's disease (HD) manifest in adulthood despite the aberrant protein being present much earlier in persons carrying the disease-causing mutation. Barnat et al.
M. Barnat, Mariacristina Capizzi, Esther Aparicio, S. Boluda, Doris Wennagel, Radhia Kacher, Rayane Kassem, Sophie Lenoir, F. Agasse, B. Y. Braz, Jeh-Ping Liu, J. Ighil, A. Tessier, S. Zeitlin, C. Duyckaerts, M. Dommergues, A. Durr, S. Humbert   +17 more
semanticscholar   +1 more source

Clinical and genetic analysis of 29 Brazilian patients with Huntington’s disease-like phenotype [PDF]

, 2011
Huntington’s disease (HD) is a neurodegenerative disorder characterized by chorea, behavioral disturbances and dementia, caused by a pathological expansion of the CAG trinucleotide in the HTT gene. Several patients have been recognized with the typical
Adrian Danek, Alexis Brice, Andrew SE, Bauer I, Bauer P, Bayreuther C, Benedikt Bader, Cellini E, Costa MC, Cécile Cazeneuve, Dobson-Stone C, Guilherme Riccioppo Rodrigues, Hirose G, Holmes SE, IBGE, Iscia Lopes-Cendes, Keckarević M, Krause A, Kremer B, Margolis RL, Martins S, McNeill A, Odile Russaouen, Rodrigues GR, Rodrigues GR, Rodriguez-Revenga L, Rosenblatt A, Ruth H. Walker, Santos C, Schmitz-Hübsch T, Stevanin G, Sułek-Piatkowska A, Teive HAG, Vitor Tumas, Vuillaume I, Wardle M, Warner JP, Wild EJ, Wilson Marques Jr.   +38 more
core   +3 more sources

Did the "Woman in the Attic" in Jane Eyre Have Huntington Disease?

Tremor and Other Hyperkinetic Movements, 2015
Background: References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. Aim: Our aim was to compare Charlotte Brontë’s depiction of Bertha Mason in Jane Eyre to the ...
Elizabeth A. Coon, Anhar Hassan
doaj   +1 more source