Results 31 to 40 of about 9,130,139 (414)
Classification of Huntington Disease using Acoustic and Lexical Features [PDF]
, 2020 Speech is a critical biomarker for Huntington Disease (HD), with changes in speech increasing in severity as the disease progresses. Speech analyses are currently conducted using either transcriptions created manually by trained professionals or using global rating scales.
arxiv +1 more source
Digital Biomarkers, 2017 Background: Clinician rating scales and patient-reported outcomes are the principal means of assessing motor symptoms in Parkinson disease and Huntington disease.
Jamie L. Adams +11 more
semanticscholar +1 more source
The Unfolded Protein Response and its potential role in Huntington's disease [PDF]
, 2012 Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla +2 more
core +2 more sources
Suicidal behaviour in huntington disease
European Psychiatry, 2021 Introduction Huntington Disease (HD) is a genetic, progressive neurodegenerative disorder. Its clinical features include motor dysfunction, cognitive impairments, and psychiatric symptoms.
R. Mota Freitas, M.T. Valadas
doaj +1 more source
Articulatory Coordination for Speech Motor Tracking in Huntington Disease [PDF]
, 2021 Huntington Disease (HD) is a progressive disorder which often manifests in motor impairment. Motor severity (captured via motor score) is a key component in assessing overall HD severity. However, motor score evaluation involves in-clinic visits with a trained medical professional, which are expensive and not always accessible. Speech analysis provides
arxiv +1 more source
Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease
American Journal of Neuroradiology, 2016 BACKGROUND AND PURPOSE: In patients with premanifest (nonsymptomatic) and advanced Huntington disease, changes in brain iron levels in the basal ganglia have been previously reported, especially in the striatum.
J. V. Bergen +8 more
semanticscholar +1 more source
Brain Communications, 2020 Huntington’s disease is characterized by a triad of motor, cognitive and psychiatric impairments, as well as unintended weight loss. Although much of the research has focused on cognitive, motor and psychiatric symptoms, the extent of peripheral ...
Cory I Wasser +6 more
semanticscholar +1 more source
Serpins : form, function and dysfunction [PDF]
, 2013 The serpin superfamily of serine protease inhibitors is one of the most ubiquitous and successful classes of inhibitors in the living world. Their unique mechanism of suicide inhibition has led to much research and several important discoveries.
Cassar, Nicholas J., Hunter, Gary J.
core +1 more source
Basal Ganglia and Thalamic Infarction
Pediatric Neurology Briefs, 1997 The signs, symptoms, and radiographic findings in 36 children, newborns to 13 years of age, with ischemic infarctions of the basal ganglia, internal capsule, or thalamus are reported from the University of Texas Southwestern Medical Center, Dallas, TX.
J Gordon Millichap
doaj +1 more source
The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease. [PDF]
, 2016 Huntington disease (HD) is an autosomal neurodegenerative disorder caused by the expansion of Polyglutamine (polyQ) in exon 1 of the Huntingtin protein. Glutamine repeats below 36 are considered normal while repeats above 40 lead to HD.
Digman, Michelle A +3 more
core +1 more source