Results 41 to 50 of about 9,201,415 (257)
A fruitful fly forward : the role of the fly in drug discovery for neurodegeneration [PDF]
, 2014 AD, Alzheimer’s disease; APP, amyloid precursor protein; BBB, blood brain barrier; GFP, green fluorescent protein; HTS, high-throughput screening; HD, Huntington’s disease; LB, Lewy bodies; PD, Parkinson’s disease; PolyQ, Polyglutamine; RNAi, RNA ...
Briffa, Michelle +2 more
core +1 more source
A Critical Review of White Matter Changes in Huntington’s Disease
Movement Disorders, 2020 Huntington’s disease is a genetic neurodegenerative disorder. White matter alterations have recently been identified as a relevant pathophysiological feature of Huntington’s disease, but their etiology and role in disease pathogenesis and progression ...
C. Casella +4 more
semanticscholar +1 more source
CellsElectroencephalogram (EEG) studies have suggested compensatory brain overactivation in cognitively healthy (CH) older adults with pathological beta-amyloid(Aβ42)/tau ratios during working memory and interference processing.
Vincent Sonny Leong +5 more
doaj +1 more source
Experience of experimental simulation of Huntington’s disease
Анналы клинической и экспериментальной неврологии, 2017 Huntingtons disease (HD) is an autosomal dominant neurodegenerativedisease characterized by choreic hyperkinesia, cognitivedecline, behavioral disorders, and progressive neuronaldeath affecting primarily the striatum.
A. V. Stavrovskaya +5 more
doaj +1 more source
Oxidative stress parameters in plasma of Huntington's disease patients, asymptomatic Huntington's disease gene carriers and healthy subjects : a cross-sectional study [PDF]
, 2007 BACKGROUND : Animal data and postmortem studies suggest a role of oxidative stress in the Huntington's disease (HD), but in vivo human studies have been scarce.
Babić, Tomislav +5 more
core +1 more source
Huntington’s Disease Clinical Trials Corner: April 2020
Journal of Huntington's Disease, 2020 In this edition of the Huntington’s Disease Clinical Trials Corner we expand on the UniQure AMT-130 and on the Neurocrine Biosciences KINECT-HD trials, and list all currently registered and ongoing clinical trials in Huntington’s disease.
F. B. Rodrigues, E. Wild
semanticscholar +1 more source
Pediatric Neurology Briefs, 1993 The clinical manifestations and outcome in 13 patients with bilateral basal ganglia lesions and neurological dysfunction are reported from the Child Neurology Unit, Vall D’Hebron University Hospital, Barcelona, Spain.
J Gordon Millichap
doaj +1 more source
Computer Methods and Programs in Biomedicine Update, 2023 Background: Unawareness of Huntington disease is prevalent where patients might have a denial of illness, less reporting of symptoms such as changes in behavior or cognitive impairment, or poor coping with the disease.
Nawal H Alharthi +2 more
doaj
Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease [PDF]
, 2015 ACKNOWLEDGEMENTS We thank the PREDICT-HD sites, the study participants, the National Research Roster for Huntington Disease Patients and Families, the Huntington’s Disease Society of America and the Huntington Study Group.
Downing, Nancy +7 more
core +1 more source
Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates. [PDF]
PLoS ONE, 2017 Huntington disease is associated with elongation of a CAG repeat in the HTT gene that results in a mutant huntingtin protein. Several studies have implicated N-terminal huntingtin protein fragments in Huntington disease pathogenesis.
Menno H Schut +9 more
doaj +1 more source