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Two Novel Lycopodium Alkaloids from Huperzia serrata
Helvetica Chimica Acta, 2002Huperzine Q (1) and N-oxyhuperzine Q (2), two novel irregular fawcettimine-type Lycopodium alkaloids were isolated from the CHCl3 fraction of the basic material of the whole plant of the Chinese medicinal herb Huperzia serrata. Their structures were determined as 13-epi-13β,16-epoxydihydrofawcettimine (1) and N-oxy-13-epi-13β,16 ...
Chang-Heng Tan +3 more
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Endophytes in the plant Huperzia serrata: fungal diversity and discovery of a new pentapeptide
Archives of Microbiology, 2014Endophytic fungi are an underexploited resource of natural products and have a capacity to produce diverse classes of plant-derived secondary metabolites. Here, we investigated the diversity of endophytic fungi from Huperzia serrata and the potential for discovering novel fungal natural products.
Zhi-Qiang, Xiong +5 more
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Chinese Journal of Chromatography, 2013
A high performance liquid chromatographic (HPLC) method was established to determine the Huperzine A in the extract of Huperzia serrata. After extracted by methanol/ water/formic acid (10/90/0.2, v/v/v), the sample was filtered for HPLC analysis. The separation was performed on an XCharge C18 column (150 mm x 4.6 mm, 5 microm) by gradient elution with ...
Jingcai, Zhang +4 more
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A high performance liquid chromatographic (HPLC) method was established to determine the Huperzine A in the extract of Huperzia serrata. After extracted by methanol/ water/formic acid (10/90/0.2, v/v/v), the sample was filtered for HPLC analysis. The separation was performed on an XCharge C18 column (150 mm x 4.6 mm, 5 microm) by gradient elution with ...
Jingcai, Zhang +4 more
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Lycopodine‐Type Lycopodium Alkaloids from Huperzia serrata
Helvetica Chimica Acta, 2004AbstractEleven Lycopodium alkaloids with a lycopodine‐type skeleton were isolated from the basic material of the whole plant of Huperzia serrata (Thunb.) Trev. (Huperziaceae). Among them, 12‐epilycodoline N‐oxide (=(12α,15R)‐12‐hydroxy‐15‐methyllycopodan‐5‐one N‐oxide; 1), 7‐hydroxylycopodine (=(15S)‐7‐hydroxy‐15‐methyllycopodan‐5‐one; 2), and 4,6α ...
Chang‐Heng Tan, Da‐Yuan Zhu
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Molecular cloning and characterization of copper amine oxidase from Huperzia serrata
Bioorganic & Medicinal Chemistry Letters, 2012A cDNA encoding a novel copper amine oxidase (CAO) was cloned and sequenced from the Chinese club moss Huperzia serrata (Huperziaceae), which produces the Lycopodium alkaloid huperzine A. A 2043-bp open reading frame encoded an Mr 76,854 protein with 681 amino acids.
Jieyin, Sun +4 more
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Lycopodium alkaloids from Huperzia serrata and their cholinesterase inhibitory activities
PhytochemistryHuperzia serrata, belonging to the Lycopodiaceae family, has been traditionally utilized for the management of treating rheumatic numbness, arthritic pain, dysmenorrhea, and contusions. This plant is a rich source of lycopodium alkaloids, some of which have demonstrated notable cholinesterase inhibitory activity.
Shuai, Jiang +3 more
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Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata
World Journal of Microbiology and Biotechnology, 2013This present study was designed to investigate the production of huperzine A (HupA), an acetylcholine inhibitor, which was produced by an endophytic fungi isolated from Huperzia serrata. Screening of 94 endophytic fungal isolates obtained from plant H. serrata was carried out for the production of HupA.
Li-Hui, Dong +4 more
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[Study on cutting and gemmae propagation of Huperzia serrata].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015An efficient and stable artificial propagation system of Huperzia serrata was established by developing the wild semi-assisted reproductive system with gemmae or the cutting of stem tip.The study was explored in the forest farm of Yantuozhai, Gaowangjie,Guzhang County, Xiangxi state and designed as a L9 (3(4)) orthogonal experiment, which consisted of ...
Hua, Long +3 more
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Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata
Tetrahedron Letters, 2000Abstract Huperzine P (1), a new irregular fawcettimine-type Lycopodium alkaloid, was isolated from Huperzia serrata and the absolute stereostructure was established by 2D NMR and X-ray crystallographic analysis.
Chang-Heng Tan +2 more
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[Effect of environmental factors on growth of Huperzia serrata].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009To establish and optimize the cultivation systems for wild Huperzia serrata, through assessing the effects of environmental factors on its growth.H. serrata was planted under natural field condition, the growth status of H. serrata under different light intensities, temperatures, relative humidity (R. H.), fertilizer levels, and so on were investigated
Zhi-an, Wang +3 more
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