Results 51 to 60 of about 7,369,692 (206)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Prior Exposure to Dry-Cured Meat Promotes Resistance to Simulated Gastric Fluid in Salmonella Typhimurium

Foods, 2019
This study assessed if exposure of foodborne Salmonella enterica in Brazilian dry-cured loin (BDL) affects pathogen inactivation in simulated gastric fluid (SGF).
Yhan S. Mutz, Denes K. A. Rosario, Vinicius S. Castro, Patricia C. Bernardes, Vania M. F. Paschoalin, Carlos A. Conte-Junior   +5 more
doaj   +1 more source

Efficacy of aqueous ozone combined with sodium metasilicate on microbial load reduction of fresh-cut cabbage

International Journal of Food Properties, 2020
The mechanism behind the sterilization effects of ozone in combination with sodium metasilicate (SM) is still unknown. Therefore, the effects of treatments of fresh-cut cabbage with aqueous ozone combined with SM on microbial growth, and produce quality ...
Meimei Nie, Caie Wu, Yadong Xiao, Jiangfeng Song, Zhongyuan Zhang, Dajing Li, Chunquan Liu   +6 more
doaj   +1 more source

Stability of vitamin C in broccoli based on the chemical reaction kinetics, micro-region state diagram, and empirical correlations

International Journal of Food Properties, 2021
Vitamin C degradation of broccoli at different moisture and temperature was measured as a function of storage time and modeled by first-order reaction kinetics. The variation of rate constant was analyzed based on the activation energy, glass transition,
Mohammad Shafiur Rahman, Sithara Suresh, Nasser Al-Habsi, Mohamed Al-Khusaibi, Zahir Al-Attabi, Lyutha Al-Subhi   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Application of Active Packaging in Refrigerated Rainbow Trout (Oncorhynchus mykiss) Fillets Treated with UV-C Radiation

Applied Sciences, 2020
This study investigated the effects of oxygen-scavenger packaging and UV-C radiation at two doses, alone or in combination, on lipid oxidation (malondialdehyde levels), protein oxidation (carbonyl content), instrumental color and texture parameters in ...
Maria Lúcia G. Monteiro, Eliane T. Mársico, Carlos A. Conte-Junior   +2 more
doaj   +1 more source

Market participation and technology adoption: An application of a triple-hurdle model approach to improved sorghum varieties in Mali

, 2021
This study examines the relationship between market participation and agricultural technology adoption. Using data collected in 2017 from 542 sorghum household farms in Mali, a triple hurdle model that integrates the three following separate stochastic ...
A. Singbo, F. Badolo, J. Lokossou, H. Affognon   +3 more
semanticscholar   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Change in Color and Volatile Composition of Skim Milk Processed with Pulsed Electric Field and Microfiltration Treatments or Heat Pasteurization

Foods, 2014
Non-thermal processing methods, such as pulsed electric field (PEF) and tangential-flow microfiltration (TFMF), are emerging processing technologies that can minimize the deleterious effects of high temperature short time (HTST) pasteurization on quality
Anupam Chugh, Dipendra Khanal, Markus Walkling-Ribeiro, Milena Corredig, Lisa Duizer, Mansel W. Griffiths   +5 more
doaj   +1 more source

Combined effect of brine salting and high-hydrostatic-pressure processing to improve the microbial quality and physicochemical properties of milkfish fillet

International Journal of Food Properties, 2022
The effects of soaking milkfish fillet in 3% or 9% NaCl brines for 90 min at 4°C, and followed by processing with varying hydrostatic pressures (300, 400, 500, and 600 MPa) for 5 min on microbial quality and physicochemical properties were evaluated ...
Yung-Hsiang Tsai, Hsien-Feng Kung, Chung-Saint Lin, Chiu-Chu Hwang, Su-Shing Lou, Chun-Yung Huang, Sam K. C. Chang, Yi-Chen Lee   +7 more
doaj   +1 more source