Results 31 to 40 of about 4,224 (165)
Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development. [PDF]
PLoS ONE, 2011 Today, there are at least a dozen different genetic disorders caused by mutations within the LMNA gene, and collectively, they are named laminopathies.
Sofía Rodríguez, Maria Eriksson
doaj +1 more source
Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde +2 more
wiley +1 more source
LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation
Aging Cell, Volume 25, Issue 9, September 2026.We present LivAge, an online aging clock that estimates murine transcriptomic age from hepatic RNA‐seq data. Externally validated, it detects accelerated aging in progeroid models and quantifies the effect of geroprotective interventions, providing an accurate, accessible, and ready‐to‐use tool for aging research.
Víctor Celemín‐Capaldi +6 more
wiley +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra +11 more
wiley +1 more source
A 3-year-old girl with old face appearance: Case report
Journal of Dermatology and Dermatologic Surgery, 2022 Hutchinson–Gilford Progeria Syndrome (HGPS) is a genetic disorder. Patients who suffer from this disorder show premature aging and a “plucked-bird” appearance on the face. This case reports a 3-year-old female, who manifested the symptoms of HGPS.
Hamad A Alfahaad
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Aging Cell, Volume 25, Issue 8, August 2026.We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre +18 more
wiley +1 more source
Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome
Przegląd Dermatologiczny, 2020 Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births.
Iti Varshney +5 more
doaj +1 more source
Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
Aging Cell, Volume 25, Issue 8, August 2026.Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez +11 more
wiley +1 more source
Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case
Вопросы современной педиатрии, 2022 Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions.
Natalia V. Buchinskaya +3 more
doaj +1 more source
The Hutchinson-Gilford progeria syndrome
The Journal of Pediatrics, 1972 The Journal of Pediatrics 80 (1972) 697-724.
Department of Pediatrics, University of Florida College of Medicine, Gainesville, Fla. USA ( host institution ) +1 more
openaire +2 more sources