Results 41 to 50 of about 1,306,775 (184)
Vascular cells derived from Hutchinson-Gilford progeria syndrome (HGPS) inducible pluripotent stem cells [PDF]
, 2014 To study the vulnerability of smooth muscle cells (SMCs) in Hutchinson-Gilford Progeria Syndrome (HGPS)
Rocha, I. +4 more
core +2 more sources
Progeria in siblings: A rare case report
Indian Journal of Dermatology, 2011 Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder.
R Sowmiya, D Prabhavathy, S Jayakumar
doaj +1 more source
Low and high expressing alleles of the LMNA gene: implications for laminopathy disease development. [PDF]
PLoS ONE, 2011 Today, there are at least a dozen different genetic disorders caused by mutations within the LMNA gene, and collectively, they are named laminopathies.
Sofía Rodríguez, Maria Eriksson
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Pharmacological inhibition of glutaminase with drug CB‐839 restores mitochondrial function in senescent myoblasts and enhances muscle strength and endurance in progeria mice. ABSTRACT Age‐associated loss of skeletal muscle mass and function, also known as sarcopenia, is closely linked to mitochondrial dysfunction.
Hamsa Vardini Senthil Kumar +7 more
wiley +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Shixiao Wang +17 more
wiley +1 more source
Estudio del envejecimiento con un modelo celular del síndrome de progeria de Hutchinson-Gilford
, 2020 Se presentan en forma resumida los principaleshallazgos del trabajo de Liu y col. (1), investigadores delInstituto Salk, California, publicado en abril de 2011, dondese describe un modelo celular in vitro del síndrome deprogeria de Hutchinson ...
de Montbrun, Dra. Lilia Cruz
core +1 more source
MTR4: A Conserved Youth Factor for Vascular Endothelium
Aging Cell, Volume 25, Issue 10, October 2026.Senescence‐induced SYVN1 degrades MTR4 via K638 ubiquitination. MTR4 loss disrupts its binding to BUB3 and destabilizes BUB3, diminishing BUBR1 and driving endothelial senescence. MTR4 restoration reverses vascular aging in mice and extends C. elegans lifespan.
Zhenyuan Guo +7 more
wiley +1 more source
A BRIEF REVIEW ON HUTCHINSON-GILFORD PROGERIA SYNDROME
, 2018 Hutchinson-Gilford Progeria Syndrome (HGPS) was first documented in 1886 in the medical literature. A HGPS patient has the physical characteristics and appearances of an elderly individual.
Savitha mol.G.M, Anaswara.S.P, Kiran.K.J, Sam Jeeva Kumar, William Arputha Sundar
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The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis
Biology of the Cell, Volume 118, Issue 10, October 2026.We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet +2 more
wiley +1 more source
Hutchinson-Gilford progeria syndrome: a rare premature ageing syndrome
Przegląd Dermatologiczny, 2020 Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births.
Iti Varshney +5 more
doaj +1 more source