Results 11 to 20 of about 13,171 (198)

Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression [PDF]

Frontiers in Immunology, 2023
IntroductionA high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a common clinical finding in a wide variety of human tumors, including those of hematological origin.MethodsWe have addressed how HVEM ...
Maria-Luisa del Rio, Carla Yago-Diez de Juan, Giovanna Roncador, Eduardo Caleiras, Ramón Álvarez-Esteban, José Antonio Pérez-Simón, Jose-Ignacio Rodriguez-Barbosa   +6 more
doaj   +2 more sources

HVEM Signalling Promotes Colitis [PDF]

PLoS ONE, 2011
PLoS ONE, 6 (4)
Schaer Corinne, Hiltbrunner Stefanie, Ernst Bettina, Mueller Christoph, Kurrer Michael, Kopf Manfred, Harris Nicola L   +6 more
openaire   +9 more sources

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses. [PDF]

PLoS ONE, 2017
Antibody based immune-checkpoint blockade therapy is a major breakthrough in oncology, leading to clinical benefit for cancer patients. Among the growing family of inhibitory receptors, the B and T lymphocyte attenuator (BTLA), which interacts with ...
Marta Spodzieja, Sławomir Lach, Justyna Iwaszkiewicz, Valérie Cesson, Katarzyna Kalejta, Daniel Olive, Olivier Michielin, Daniel E Speiser, Vincent Zoete, Laurent Derré, Sylwia Rodziewicz-Motowidło   +10 more
doaj   +2 more sources

HVEM gene polymorphisms are associated with sporadic breast cancer in Chinese women. [PDF]

PLoS ONE, 2013
As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity.
Dalin Li, Zhenkun Fu, Shuang Chen, Weiguang Yuan, Yanhong Liu, Liqun Li, Da Pang, Dianjun Li   +7 more
doaj   +2 more sources

Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss [PDF]

Endocrinology and Metabolism, 2013
BackgroundReduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM)
Kwang Kon Kim, Sung Ho Jin, Byung Ju Lee
doaj   +1 more source

HVEM/HIF-1α promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions

Journal of Ovarian Research, 2020
Background Our previous studies showed the expression of herpes virus entry mediator (HVEM) is high in ovarian cancer samples and correlated to the patient clinic pathological features. As we all know, the hypoxic environment is the main feature of tumor.
Liyan Duan, Jie Tao, Xiaoqian Yang, Lei Ye, Yueqian Wu, Qizhi He, Yingchun Duan, Li Chen, Jianlong Zhu   +8 more
doaj   +1 more source

Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

Frontiers in Medicine, 2023
IntroductionThe co-regulatory molecule, HVEM, can stimulate or inhibit immune function, but when co-expressed with BTLA, forms an inert complex preventing signaling.
Michelle E. Wakeley, Brandon E. Armstead, Brandon E. Armstead, Chyna C. Gray, Chyna C. Gray, Elizabeth W. Tindal, Daithi S. Heffernan, Chun-Shiang Chung, Alfred Ayala   +8 more
doaj   +1 more source

Binding of herpesvirus entry mediator (HVEM) and HSV-1 gD affect reactivation but not latency levels.

PLoS Pathogens, 2023
Previously we reported that the HSV-1 latency associated transcript (LAT) specifically upregulates the cellular herpesvirus entry mediator (HVEM) but no other known HSV-1 receptors.
Ujjaldeep Jaggi, Shaohui Wang, Kevin R Mott, Homayon Ghiasi   +3 more
doaj   +1 more source

Molecular Characterization of the Native (Non-Linked) CD160–HVEM Protein Complex Revealed by Initial Crystallographic Analysis

Crystals, 2021
An increasing number of surface-exposed ligands and receptors acting on immune cells are being considered as a starting point in drug development applications.
Simona Lenhartová, Marek Nemčovič, Radka Šebová, Mário Benko, Dirk M. Zajonc, Ivana Nemčovičová   +5 more
doaj   +1 more source

Allosteric regulation of binding specificity of HVEM for CD160 and BTLA ligands upon G89F mutation

Current Research in Structural Biology, 2021
Molecular interactions mediated by engagement of the Herpes virus entry mediator (HVEM) with members of TNF and Ig superfamily generate distinct signals in T cell activation pathways that modulate inflammatory and inhibitory responses.
Rojan Shrestha, Sarah Garrett-Thomson, Weifeng Liu, Steven C. Almo, Andras Fiser   +4 more
doaj   +1 more source