Results 21 to 30 of about 13,171 (198)

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

OncoImmunology, 2017
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses.
Kostandinos Sideras, Katharina Biermann, Joanne Verheij, Bart R. Takkenberg, Shanta Mancham, Bettina E. Hansen, Hannah M. Schutz, Robert A. de Man, Dave Sprengers, Sonja I. Buschow, Maddy C. M. Verseput, Patrick P. C. Boor, Qiuwei Pan, Thomas M. van Gulik, Turkan Terkivatan, Jan N. M. Ijzermans, Ulrich H. W. Beuers, Stefan Sleijfer, Marco J. Bruno, Jaap Kwekkeboom   +19 more
doaj   +1 more source

HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160 [PDF]

, 2021
HVEM is a TNF (tumor necrosis factor) receptor contributing to a broad range of immune functions involving diverse cell types. It interacts with a TNF ligand, LIGHT, and immunoglobulin (Ig) superfamily members BTLA and CD160.
Kim, Kenneth, Weifeng Liu, Kiyokazu Kakugawa, Hilde Cheroutre, Kakugawa, Kiyokazu, Fedorov, Elena, Liu, Weifeng, Wang, Qingyang, Ting-Fang Chou, Kenneth Kim, Elena Fedorov, Kronenberg, Mitchell, Goo-Young Seo, Udupi A. Ramagopal, Chou, Ting-Fang, Cheroutre, Hilde, Steven C. Almo, Jeffrey B. Bonanno, Almo, Steven C, Sarah C. Garrett-Thomson, Mitchell Kronenberg, Seo, Goo-Young, Garrett-Thomson, Sarah C, Scott J. Garforth, Garforth, Scott J, Bonanno, Jeffrey B, Qingyang Wang, Ramagopal, Udupi A   +27 more
core   +1 more source

Herpesvirus Entry Mediator on Radiation-Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry-Independent Manner

mBio, 2015
Ocular herpes simplex virus 1 (HSV-1) infection leads to a potentially blinding immunoinflammatory syndrome, herpes stromal keratitis (HSK). Herpesvirus entry mediator (HVEM), a widely expressed tumor necrosis factor (TNF) receptor superfamily member ...
Rebecca G. Edwards, Sarah J. Kopp, Andrew H. Karaba, Douglas R. Wilcox, Richard Longnecker   +4 more
doaj   +1 more source

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota

Frontiers in Immunology, 2022
The herpes virus entry mediator (HVEM) is an immune checkpoint molecule regulating immune response, but its role in tissue repair remains unclear. Here, we reported that HVEM deficiency aggravated hepatobiliary damage and compromised liver repair after 3,
Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang   +11 more
doaj   +1 more source

Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. [PDF]

, 2022
Intraepithelial T cells (IETs) are in close contact with intestinal epithelial cells and the underlying basement membrane, and they detect invasive pathogens.
Charles D. Surh, Hilde Cheroutre, Sethi, Ashu, Wang, Qingyang, Shui, Jr-Wen, Ting-Fang Chou, Daisuke Takahashi, Mikulski, Zbigniew, Takahashi, Masumi, Takahashi, Daisuke, Kronenberg, Mitchell, Goo-Young Seo, Chou, Ting-Fang, Cheroutre, Hilde, Chen, Angeline, Paola Marcovecchio, Ashu Sethi, Sara McArdle, Seo, Goo-Young, Mitchell Kronenberg, Angeline Chen, McArdle, Sara, Marcovecchio, Paola, Zbigniew Mikulski, Qingyang Wang, Jr-Wen Shui, Masumi Takahashi, Surh, Charles   +27 more
core   +1 more source

Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastomaResearch in context

EBioMedicine, 2019
Background: Dysregulation of immune checkpoint molecules leads to immune evasion in human tumours but has become a viable target for tumour therapy. Here, we examined expression of Herpes virus entry mediator (HVEM), an immune checkpoint molecule, in ...
Ming-Zhi Han, Shuai Wang, Wen-Bo Zhao, Shi-Lei Ni, Ning Yang, Yang Kong, Bin Huang, An-Jing Chen, Xin-Gang Li, Jian Wang, Dong-Hai Wang   +10 more
doaj   +1 more source

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection

mBio, 2020
Ocular herpes simplex virus 1 (HSV-1) infection leads to an immunopathogenic disease called herpes stromal keratitis (HSK), in which CD4+ T cell-driven inflammation contributes to irreversible damage to the cornea. Herpesvirus entry mediator (HVEM) is an
Seo J. Park, Rachel E. Riccio, Sarah J. Kopp, Igal Ifergan, Stephen D. Miller, Richard Longnecker   +5 more
doaj   +1 more source

CD8 T cell memory to a viral pathogen requires trans cosignaling between HVEM and BTLA. [PDF]

PLoS ONE, 2013
Defining the molecular interactions required to program activated CD8 T cells to survive and become memory cells may allow us to understand how to augment anti-viral immunity.
Rachel Flynn, Tarun Hutchinson, Kenneth M Murphy, Carl F Ware, Michael Croft, Shahram Salek-Ardakani   +5 more
doaj   +1 more source

Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2

Cells, 2022
B and T lymphocyte attenuator (BTLA) is an immune checkpoint molecule that mediates the escape of tumor cells from immunosurveillance. Consequently, BTLA and its ligand herpesvirus entry mediator (HVEM) are potentially immunotherapeutic targets. However,
Tian-You Cheng, Ya-Juan Liu, Hong Yan, Yi-Bo Xi, Li-Qiang Duan, Yang Wang, Tian-Tian Zhang, Yin-Min Gu, Xiao-Dong Wang, Chang-Xin Wu, Shan Gao   +10 more
doaj   +1 more source

Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo

Molecular Therapy: Oncolytics, 2021
Because most patients with multiple myeloma (MM) develop resistance to current regimens, novel approaches are needed. Genetically modified, replication-competent oncolytic viruses exhibit high tropism for tumor cells regardless of cancer stage and prior ...
Jayeeta Ghose, Ada Dona, Mariam Murtadha, Emine Gulsen Gunes, Enrico Caserta, Ji Young Yoo, Luke Russell, Alena Cristina Jaime-Ramirez, Benjamin G. Barwick, Vikas A. Gupta, James F. Sanchez, Douglas W. Sborov, Steven T. Rosen, Amrita Krishnan, Lawrence H. Boise, Balveen Kaur, Craig C. Hofmeister, Flavia Pichiorri   +17 more
doaj   +1 more source