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Cellular and Molecular Life Sciences, 2007 The polysaccharide hyaluronan is an essential component of the vertebrate extracellular matrix and also produced by viruses, bacteria and fungi. Although the hyaluronan polymer is simply a disaccharide that repeats many thousands of times, it has an amazing array of biological functions and medical uses.
Almond, A.; id_orcid
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Hyaluronan: Biosynthesis and signaling
Biochimica Et Biophysica Acta - General Subjects, 2014 Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
Davide Vigetti +2 more
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Birth Defects Research Part C: Embryo Today: Reviews, 2004
AbstractIn the past decade, there has been an explosion of interest in hyaluronan, an often misunderstood, biochemically simple, yet functionally complex carbohydrate polymer that is a resident of many extracellular matrices. Previously thought of as a passive, space‐filling component of the extracellular matrix, the so‐called “goo” concept, hyaluronan
Andrew P, Spicer, Janet Y L, Tien
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AbstractIn the past decade, there has been an explosion of interest in hyaluronan, an often misunderstood, biochemically simple, yet functionally complex carbohydrate polymer that is a resident of many extracellular matrices. Previously thought of as a passive, space‐filling component of the extracellular matrix, the so‐called “goo” concept, hyaluronan
Andrew P, Spicer, Janet Y L, Tien
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Role of hyaluronan and hyaluronan synthase in endometrial cancer
Oncology Reports, 2005The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women.
Hiromitsu, Yabushita +7 more
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Hyaluronan–Phospholipid Interactions
Journal of Structural Biology, 1997Hyaluronan-phospholipid interactions have been studied in vitro by negative staining and rotary shadowing electron microscopy. Hyaluronan (HA) molecules of different molecular weights (around 170,000; 740,000, and 1.9 x 10(6) Da) were added to phospholipid suspensions (DPPC or egg lecithin) that were in the form of either unilamellar particles or ...
RONCHETTI, Ivonne +4 more
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Journal of Internal Medicine, 1997
Toole BP (Tufts University School of Medicine, Boston, MA, USA). Hyaluronan in morphogenesis (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 35–40.Pericellular matrices surrounding migrating and proliferating cells in the developing embryo, in regenerating tissues and in other dynamic cellular events, such as tumour cell invasion, are enriched in ...
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Toole BP (Tufts University School of Medicine, Boston, MA, USA). Hyaluronan in morphogenesis (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 35–40.Pericellular matrices surrounding migrating and proliferating cells in the developing embryo, in regenerating tissues and in other dynamic cellular events, such as tumour cell invasion, are enriched in ...
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Hyaluronan: polysaccharide chaos to protein organisation
Current Opinion in Structural Biology, 2001 Molecular dynamics simulations of hyaluronan have revealed the inherent flexibility of this glycosaminoglycan in solution. Crystal structures of hyaluronan-digesting enzymes have provided the first direct insights into the molecular basis of hyaluronan ...
Anthony J Day, J K Sheehan
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Acta Oto-Laryngologica, 1987
Hyaluronan (hyaluronic acid) is a linear polysaccharide formed from disaccharide units containing N-acetylglucosamine and glucuronic acid. It is ubiquitously distributed in the organism but is found in the highest concentrations in soft connective tissues. The molecular weight of hyaluronan is usually in the order of 10(6) to 10(7).
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Hyaluronan (hyaluronic acid) is a linear polysaccharide formed from disaccharide units containing N-acetylglucosamine and glucuronic acid. It is ubiquitously distributed in the organism but is found in the highest concentrations in soft connective tissues. The molecular weight of hyaluronan is usually in the order of 10(6) to 10(7).
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Hyaluronan and Hyaluronan Fragments
2017The glycosaminoglycan hyaluronan (HA) is a key component of the microenvironment surrounding cells. In healthy tissues, HA molecules have extremely high molecular mass and consequently large hydrodynamic volumes. Tethered to the cell surface by clustered receptor proteins, HA molecules crowd each other, as well as other macromolecular species.
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Journal of biological regulators and homeostatic agents, 2017
Hyaluronic acid (HA) is a polyanionic natural polymer occurring as a linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, non-toxicity, non-immunogenicity and serves as an excellent ...
Abbruzzese F +7 more
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Hyaluronic acid (HA) is a polyanionic natural polymer occurring as a linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, non-toxicity, non-immunogenicity and serves as an excellent ...
Abbruzzese F +7 more
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