Results 51 to 60 of about 82,581 (251)

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

International Journal of Molecular Sciences, 2020
The ovarian stroma, the microenvironment in which female gametes grow and mature, becomes inflamed and fibrotic with age. Hyaluronan is a major component of the ovarian extracellular matrix (ECM), and in other aging tissues, accumulation of low molecular
Jennifer E. Rowley, Farners Amargant, L. Zhou, Anna M. Galligos, Leah E. Simon, M. Pritchard, F. Duncan   +6 more
semanticscholar   +1 more source

Unravelling the immunomodulatory role of hyaluronan in prostate cancer development

, 2023
reservedProstate cancer (PCa) is implicated as the most frequently diagnosed non-skin cancer and the second-leading cause of cancer-related death in males.
SAFARZADEH, ALI
core  

LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan

Journal of Cell Biology, 1999
The extracellular matrix glycosaminoglycan hyaluronan (HA) is an abundant component of skin and mesenchymal tissues where it facilitates cell migration during wound healing, inflammation, and em- bryonic morphogenesis.
S. Banerji, J. Ni, Shu-Xia Wang, S. Clasper, Jeffrey Y. Su, R. Tammi, Margaret E. Jones, D. Jackson   +7 more
semanticscholar   +1 more source

Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

International Journal of Cell Biology, 2015
Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the
Jaime M. Cyphert, Carol S. Trempus, Stavros Garantziotis   +2 more
doaj   +1 more source

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Reproductive Biology and Endocrinology, 2022
Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang, Long Bai, Yi-Min Zhu, Peter C. K. Leung   +3 more
doaj   +1 more source

Impact of Ergothioneine, Hercynine, and Histidine on Oxidative Degradation of Hyaluronan and Wound Healing

Polymers, 2020
A high-molecular weight hyaluronan is oxidatively degraded by Cu(II) ions and ascorbate—the so called Weissberger biogenic oxidative system—which is one of the most potent generators of reactive oxygen species, namely •OH radicals.
Katarína Valachová, K. Švík, C. Bíró, M. Collins, R. Jurčík, Ľ. Ondruška, L. Šoltés   +6 more
semanticscholar   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

HYALURONAN STIMULATES KERATINOCYTE MIGRATION AND ACTIVATES THE TRANSCRIPTION FACTOR AP-1 IN KERATINOCYTES THROUGH THE JNK PATHWAY

, 2002
Hyaluronan (HA) has been considered a passive extracellular matrix (ECM) polysaccharide, but recent studies have shown its importance in controlling many cell functions including motility, proliferation and adhesion, which imply signaling from ECM to ...
Kari Törrönen, Raija Tammi, Kai Kaarniranta, Lammi, Mikko,, Kirsi Rilla, Törrönen, Kari,, Rilla, Kirsi,, Yabal, Monica,, Tammi, Markku,, Markku Tammi, Monica Yabal, Mikko J. Lammi, Kaarniranta, Kai,, Tammi, Raija,   +13 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage

Stem Cells International, 2016
Background. Biological therapeutics such as adipose-derived mesenchymal stem cell (MSC) therapy are gaining acceptance for knee-osteoarthritis (OA) treatment.
Peter Succar, Michael Medynskyj, Edmond J. Breen, Tony Batterham, Mark P. Molloy, Benjamin R. Herbert   +5 more
doaj   +1 more source