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Immunological functions of hyaluronan and its receptors in the lymphatics

Immunological Reviews, 2009
Summary:  The lymphatic system is best known for draining interstitial fluid from the tissues and returning it to the blood circulation. However, the lymphatic system also provides the means for immune surveillance in the immune system, acting as conduits that convey soluble antigens and antigen‐presenting cells from the tissues to the lymph nodes ...
D. Jackson
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Hyaluronan-binding receptors: possible involvement in osteoarthritis

Modern Rheumatology, 2009
Our objectives were to compare the expression of the hyaluronan receptors CD44 and RHAMM in knee synovial tissue of patients with and without advanced osteoarthritis (OA). Both receptors were detected immunohistochemically; the staining appeared more intense in the tissues from the patients with advanced OA.
Sharon Dunn, O. Kolomytkin, D. Waddell, Andrew A. Marino   +3 more
semanticscholar   +4 more sources

The hyaluronan receptor, CD44

The International Journal of Biochemistry & Cell Biology, 2002
CD44 is a widely expressed cell surface hyaluronan receptor which plays a key role in mediating cell migration. A number of recent papers demonstrating an interplay between CD44 and matrix metalloproteinases (MMPs) have shed important insights into the molecular mechanisms underlying these events.
Clare M. Isacke, Helen Yarwood
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Hyaluronan network: a driving force in cancer progression.

American Journal of Physiology - Cell Physiology, 2022
Hyaluronan is one of the most abundant macromolecules of the extracellular matrix and regulates several physiological cell and tissue properties. However, hyaluronan has been shown to accumulate together with its receptors in various cancers.
Theodoros Karalis, S. Skandalis
semanticscholar   +1 more source

Receptors for Hyaluronan on Corneal Endothelial Cells

Experimental Eye Research, 1994
Previous investigations suggest that the corneal endothelium has specific binding sites for hyaluronan (HYA). In the present study, biochemical and immunological techniques were used to characterize these binding sites and to compare them with the liver endothelial cell (LEC) HYA receptor.
Stefan Gustafson, W Rolfsen, A. Von Malmborg, Nina Forsberg, K Madsen   +4 more
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Internalization of the Hyaluronan Receptor CD44 by Chondrocytes

Experimental Cell Research, 1999
Chondrocytes express CD44 as a primary receptor for the matrix macromolecule hyaluronan. Hyaluronan is responsible for the retention and organization of proteoglycan within cartilage, and hyaluronan-chondrocyte interactions are important for the assembly and maintenance of the cartilage matrix.
Warren Knudson, Cheryl B. Knudson, Dean J. Aguiar   +2 more
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Hyaluronan and its receptors in mucoepidermoid carcinoma

Head & Neck, 2006
Hyaluronan (HA) is a prominent extracellular matrix component undergoing continuous production and degradation. Increased HA levels have been described in a variety of tumors. The objective of this study was to examine the staining patterns of HA and two of its associated receptors (CD44 and HARE) in relation to the metastatic potential of ...
Timothy D. Doerr, Janet A. Weigel, Richard O. Wein, John L. Howard, Carl T. McGary, Saurin R. Popat, Paul H. Weigel   +6 more
openaire   +3 more sources

Potential Role for Hyaluronan and the Hyaluronan Receptor RHAMM in Mobilization and Trafficking of Hematopoietic Progenitor Cells [PDF]

Blood, 1999
AbstractAlthough the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34+45lo/medScatterlo/med HPCs from granulocyte colony-stimulating factor
Linda M. Pilarski, Michael J. Mant, Michael J. Mant, Karen Seeberger, Karen Seeberger, Christopher B. Brown, Christopher B. Brown, Darlene Paine, Darlene Paine, Juanita Wizniak, Juanita Wizniak, Eva Pruski, Eva Pruski, Andrew R. Belch, Andrew R. Belch   +14 more
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Ras-transformed cells express both CD44 and RHAMM hyaluronan receptors: only RHAMM is essential for hyaluronan-promoted locomotion.

Experimental Cell Research, 1993
Hyaluronan (HA) is an important regulator of cell locomotion. We show that ras-transformed cells, termed 245 cells, respond to HA with an increase in random locomotion.
E. Turley, L. Austen, D. Moore, K. Hoare
semanticscholar   +1 more source

Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression.

International Journal of Oncology, 2000
Interactions of hyaluronic acid (HA) with its binding proteins CD44 and RHAMM (receptor for HA-mediating motility) have been proposed to be important in promoting tumor progression and dissemination.
H. Li, Lee Guo, Jun-Wei Li, N. Liu, Rong Qi, J. Liu   +5 more
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