Results 301 to 310 of about 2,312,745 (333)

The regulation of sperm motility by a novel hyaluronan receptor

Fertility and Sterility, 1994
To determine if a novel receptor for hyaluronan, termed RHAMM, is responsible for the previously observed increase in sperm locomotion in response to hyaluronan and to assess whether expression of the RHAMM protein is involved in sperm motility.The RHAMM protein was localized on human sperm by immunofluorescence of fixed cells, fluorescence-activated ...
John A. McCoshen, Barbara S. Kornovski, Eva A. Turley, Jeremy V. Kredentser   +3 more
openaire   +3 more sources

Calcium‐Sensing Receptor function regulation by hyaluronan

The FASEB Journal, 2020
Mice exposure to halogens, chlorine (Cl2) or bromine (Br2), develop increased airway resistance and airway hyper‐responsiveness (AHR) to methacholine, which lasted for at least one‐week post exposure. Herein, we investigated the mechanisms involved. Mice exposed to halogens (600 ppm Br2 or 400 ppm Cl2) for 30 min developed AHR 24 hours post exposure ...
Ahmed Lazrak, Sadis Matalon, Zhihong Yu
openaire   +1 more source

Study of Hyaluronan-Binding Proteins and Receptors Using Iodinated Hyaluronan Derivatives

2003
This chapter detailed methodology for the purification of high molecular weight HA, as well as procedures to fragment the HA to prepare large oligosaccharides in the range of 40,000-80,000 Da. The aforementioned procedures used to prepare HA-alkylamine and HA-Bolton-Hunter adducts, as well as 125I-labeled HA, have been very reproducible, and the latter
Janet A. Weigel, Carl T. McGary, Paul H. Weigel   +2 more
openaire   +3 more sources

Regulation of hyaluronan production by β2 adrenergic receptor signaling

Biochemical and Biophysical Research Communications, 2021
Hyaluronan (HA), the main component of the extracellular matrix, is involved in tissue elasticity and cell scaffolding, and in progression of conditions such as cancer, inflammation and wound healing. Signaling by G protein coupled receptor (GPCR) activation increases expression of hyaluronan synthase (HAS) and HA production. The β2 adrenergic receptor
Hideyoshi Higashi, Yoshiyuki Kuroda
openaire   +2 more sources

Hyaluronan-binding proteins and receptors

Advanced Drug Delivery Reviews, 1991
Abstract Hyaluranon is a glycosaminoglycan implicated in development, repair and disease processes. It appears to regulate these processes, in part, by interacting with specific binding proteins. These proteins can be conveniently divided into those that are primarily extracellular, including aggrecan, link protein(s), versican, hyaluronection or ...
openaire   +2 more sources

Characterization of the murine gene encoding the hyaluronan receptor RHAMM

Gene, 1995
We describe the isolation and characterization of the murine gene encoding RHAMM, a hyaluronan receptor which regulates focal adhesion turnover, is required for cell locomotion and is a critical downstream regulator of ras transformation. The RHAMM gene spans at least 20 kb and comprises 14 exons ranging in size from 75 to 1099 bp.
Arnold H. Greenberg, Eva A. Turley, Joycelyn Entwistle, Baihua Yang, Michael R. A. Mowat, Carol Wong, Jingbo A, Christine L. Hall, Qun Li, Shiwen Zhang   +9 more
openaire   +3 more sources

Characterization and purification of the hyaluronan-receptor on liver endothelial cells

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1991
In order to characterize the proteins on liver endothelial cells that bind hyaluronan (HYA), liver endothelial cells were surface-iodinated with 125I, solubilized by Triton X-100 and passed through a column containing HYA coupled to agarose. The column was washed and eluted with HYA-oligosaccharides.
Stefan Gustafson, Nina Forsberg
openaire   +3 more sources

The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11.

Genomics, 1995
The gene for the receptor for hyaluronan-mediated motility, RHAMM (designated hyaluronan-mediated motility receptor, HMMR (human) and Hmmr (mouse), for mapping purposes), was localized to human chromosome 5q33.2-qter by somatic cell and radiation hybrid ...
A. Spicer, M. Roller, S. Camper, J. McPherson, J. Wasmuth, S. Hakim, C. Wang, E. Turley, J. McDonald   +8 more
semanticscholar   +1 more source

Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare

Theriogenology, 2011
Hyaluronan (HA), a glycosaminoglycan, is a major component of the pericellular matrix which envelopes mammalian cells. Binding of hyaluronan to one of its specific receptors, CD44, modulates transduction of intracellular signals which direct a variety of processes, including embryogenesis, wound healing, inflammation, and neoplasia. Since regulation of
Allison J. Stewart, Fred J. Caldwell, M. Harrie, M. Harrie, Elizabeth M. Whitley, Elizabeth M. Whitley, I. Rodriguez Hurtado, Dwight F. Wolfe   +7 more
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Hyaluronan synthases, hyaluronan, and its CD44 receptor in tissue around loosened total hip prostheses

The Journal of Pathology, 2001
Aseptic loosening of prosthetic components, the most common long-term complication after total hip replacement (THR), is characterized by the formation of a synovial membrane-like interface tissue (SMLIT). It was hypothesized that the hyaluronan synthase (HAS)/hyaluronan (HA)/HA receptor CD44 signalling system is responsible for the synovial-like ...
Jan Lassus, Seppo Santavirta, Ismo Virtanen, Raija Tammi, Yrjö T. Konttinen, Tian-Fang Li, Tian-Fang Li, Jami Mandelin, Markku Tammi, Mari Ainola   +9 more
openaire   +3 more sources