Results 121 to 130 of about 280,731 (250)

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

Cloning and expression of hyaluronan synthase (hasA) in recombinant Escherichia coli BL21 and its hyaluronic acid production in shake flask culture

, 2019
Aims: Hyaluronic acid (HA) is a high molecular weight polymer and a major component of mucoid capsule in bacteria and extracellular matrix (ECM) of vertebrate tissue. Due to its unique characteristics, HA is used extensively in medical and cosmetic field.
Z. Lai, C. Teo
semanticscholar   +1 more source

Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction [PDF]

, 2004
Hyaluronan is a major molecule in joint fluid and plays a crucial role in joint motion and the maintenance of joint homeostasis. The concentration and average molecular weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid
Fujii, Katsuyuki, Itano, Naoki, Kimata, Koji, Marumo, Keishi, Sai, Shigaku, Tanaka, Takaaki, Yoshida, Mamoru   +6 more
core   +2 more sources

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, EarlyView.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj  

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

Molecular Cancer, 2011
Background Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed.
Savani Rashmin C, Stoecklein Nikolas H, Knoefel Wolfram T, Prenzel Klaus, Alves Frauke, Dullin Christian, Jannasch Katharina, Dai Guang, Poscher Eva, Freudenberger Till, Twarock Sören, Homey Bernhard, Fischer Jens W   +12 more
doaj   +1 more source

Cell density dependent stimulation of PAI-1 and hyaluronan synthesis by TGF-[béta] in orbital fibroblasts [PDF]

, 2018
L
Berta, Eszter, Erdei, Annamária, Galgóczi, Erika, Gazdag, Annamária, Győry, Ferenc, Jeney, Florence, Katkó, Mónika, M. Nagy, Domonkos, Nagy, Endre V., Steiber, Zita, Ujhelyi, Bernadett   +10 more
core   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3. The low expression level of HASs in normal keratinocytes and other various types of cells presents a recognized challenge, impeding biological and pathological research on ...
Jie Wang, Zhikun Wu, Liang Cao, Feng Long   +3 more
openalex   +4 more sources

Wound healing and hyper-hydration - a counter intuitive model [PDF]

, 2016
Winters seminal work in the 1960s relating to providing an optimal level of moisture to aid wound healing (granulation and re-epithelialisation) has been the single most effective advance in wound care over many decades.
Atiyeh B.S., Atiyeh B.S., Bolton L.L., Charlesworth B., Crowther J.M., Dumville J.C., Eaglstein W.H., Faria D., Fletcher J., Gabriel A., Gray D., Harding K., Jones V., Leung B.K., Lewis T., Park A.C., Parker B., Romanelli M., Rubio P.A., Rusak A., Ruttermann M., Scheuplein R., Thomas S., Triller C   +23 more
core   +1 more source