Results 101 to 110 of about 10,976 (205)

Interleukin-1 Beta Mediated Regulation of Hyaluronan and Hyaluronan Synthase 2

, 2005
Elevated levels of hyaluronan are associated with numerous inflammatory diseases including ulcerative colitis, Crohn\u27s disease and wound healing. Various proinflammatory cytokines have shown to influence hyaluronan expression in cells originating ...
Ducale, Ashley Elizabeth
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Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice

Cell Journal, 2018
Objective Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin.
Maryam Ezzati , Leila Roshangar, Jafar Soleimani, Nahid karimian   +3 more
doaj   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source

Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance [PDF]

, 2015
The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle.
Faulkes, CG, Bennett, Nigel Charles, Davies, KTJ, Davies, Kalina T.J., Rossiter, Stephen J., Bennett, NC, Rossiter, SJ, Faulkes, Christopher G.   +7 more
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Investigation of Hyaluronan Synthase 2 and CD44 immune reactivity as a biomarker to predict Progesterone-Resistant Endometrial Hyperplasia without atypia: A retrospective case-control study

Indian Journal of Pathology and Microbiology
Background/Aims: In our study, the effect of hyaluronan synthase 2 (HAS2) and CD44 immunoreactivity as a predictive biomarker in the prediction of progesterone-resistant endometrial hyperplasia (EH) cases without atypia was investigated.
Emine Boybay, Remzi Atilgan, Şehmus Pala, Tuncay Kuloğlu, Gökhan Artaş   +4 more
doaj   +1 more source

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

, 2000
We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2-/- embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die
Tammy Brehm-Gibson, Klewer, Scott E., Calabro, Anthony, Jr., Scott E. Klewer, Spicer, Andrew P., Brehm-Gibson, Tammy, Augustine, Mary Lou, Kubalak, Steven, Jennifer Biesterfeldt, Jennifer, Andrew P. Spicer, Anthony Calabro, Todd D. Camenisch, Steven Kubalak, Mary Lou Augustine, Jennifer Biesterfeldt, Camenisch, Todd D., John A. McDonald   +16 more
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Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases

, 2012
Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Eggink, G., Chavaroche, A.A.E., Boeriu, C.G., van den Broek, L.A.M., Broek, L.A.M., van den   +4 more
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Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer

Obstetrics and Gynecology International, 2011
The role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated.
Hiromitsu Yabushita, Keita Iwasaki, Kouhei Kanyama, Yukihiko Obayashi, Lisheng Zhuo, Naoki Itano, Koji Kimata, Akihiko Wakatsuki   +7 more
doaj   +1 more source

Functional analysis of human hyaluronan synthase 3 splicing variant 2

, 2010
Hyaluronan is a large glycosaminoglycan mainly presented in the extracellular matrix as well as in the intracellular compartment. Hyaluronan is synthesized by three hyaluronan synthase isoforms, namely HAS1, HAS2 and HAS3.
Dai, Guang
core  

Hyaluronan: Biosynthesis and signaling

, 2014
Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
Manuela Viola, DE LUCA, GIANCARLO, Eugenia Karousou, Alberto Passi, PASSI, ALBERTO, Giancarlo De Luca, Sara Deleonibus, VIGETTI, DAVIDE, KAROUSOU, EVGENIA, Deleonibus, S., VIOLA, MANUELA, Davide Vigetti   +11 more
core   +1 more source