Results 91 to 100 of about 10,179 (169)

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3. The low expression level of HASs in normal keratinocytes and other various types of cells presents a recognized challenge, impeding biological and pathological research on ...
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
openaire   +3 more sources

Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2. [PDF]

Sci Rep, 2021
Nazeri A, Niazi A, Afsharifar A, Taghavi SM, Moghadam A, Aram F.   +5 more
europepmc   +1 more source

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. [PDF]

Exp Mol Med, 2022
Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E.   +7 more
europepmc   +1 more source

An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.

The Journal of biological chemistry, 2004
The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Hiroko, Hoshi, Hiroaki, Nakagawa, Susumu, Nishiguchi, Kazumichi, Iwata, Kenichi, Niikura, Kenji, Monde, Shin-Ichiro, Nishimura   +6 more
openaire   +1 more source

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma. [PDF]

Arch Med Sci, 2023
Akgun H, Metintas S, Ak G, Demirkol Canlı S, Isbilen M, Gure AO, Metintas M.   +6 more
europepmc   +1 more source

Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration. [PDF]

Front Immunol
Niemann V, Brack F, Rolauer L, Kaczur J, Petzsch P, Köhrer K, Quast C, Gerdes N, Bouvain P, Voigt K, Krüger M, Brückner A, Fleischmann BK, Wenzel D, Barnowski P, Zimmermann LM, Simsekyilmaz S, Filler T, Ibing W, Feige T, Krott KJ, Wagenhäuser MU, Fischer JW, Elvers M, Sengle G, Flögel U, Hundhausen C, Suvorava T, Grandoch M.   +28 more
europepmc   +1 more source

Transcriptional regulation of the human hyaluronan synthase genes: focus on hyaluronan synthase 2 [PDF]

This thesis examines the transcriptional regulation of the human hyaluronan synthase (HAS) genes, with particular focus on hyaluronan synthase 2. The data details the reconstruction of the genomic structures of each HAS isoform for the first time, as well as analysis of the activity of each HAS proximal promoter.
openaire  

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]

Proteoglycan Res
Queisser KA, Smith L, Leung G, Albtoush N, Mellema RA, Petrey AC.   +5 more
europepmc   +1 more source

Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324. [PDF]

Biomedicines
Li Y, Tress A, Maye P, Edwards K, Findletar A, Dyment NA, Yamaguchi Y, Rowe DW, Le-Chan G, Chan SSK, Lo KW.   +10 more
europepmc   +1 more source

Hyaluronan Synthase 2 [PDF]

, 2020
openaire   +1 more source