Results 71 to 80 of about 10,179 (169)

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling after Arterial Ischemia

Cells, 2020
We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds.
Gangqi Wang, Margreet R. de Vries, Wendy M. P. J. Sol, Annemarie M. van Oeveren-Rietdijk, Hetty C. de Boer, Anton Jan van Zonneveld, Paul H. A. Quax, Ton J. Rabelink, Bernard M. van den Berg   +8 more
doaj   +1 more source

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp, Linda B. Pratt, Callan J. Schroder, Joseph D. Staab, Grant D. Hatcher, Joshua T. McWilliams, Michael C. Wilhelm, Ashley C. Texel, Edward N. Harris   +8 more
wiley   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, Volume 56, Issue 7, Page 769-783, July 2026.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

Molecular Cancer, 2011
Background Oesophageal cancer is a highly aggressive tumour entity with at present poor prognosis. Therefore, novel treatment options are urgently needed.
Savani Rashmin C, Stoecklein Nikolas H, Knoefel Wolfram T, Prenzel Klaus, Alves Frauke, Dullin Christian, Jannasch Katharina, Dai Guang, Poscher Eva, Freudenberger Till, Twarock Sören, Homey Bernhard, Fischer Jens W   +12 more
doaj   +1 more source

Hyaluronan Synthases [PDF]

Journal of Biological Chemistry, 1997
P H, Weigel, V C, Hascall, M, Tammi
openaire   +2 more sources

Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]

PeerJ
Background Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan, Mohammed Baradwan, Alaa Bagalagel, Reem Diri, Ahmed Basilim, Mohammed Z. Nasrullah, Abdulhamid Althagafi, Hussam I. Kutbi, Abdulaziz A. Mohammed, Hanan M. Alshan, Mohammed M.H. Al-Gayyar   +10 more
doaj   +2 more sources

HAS2 (hyaluronan synthase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice

Cell Journal, 2018
Objective Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin.
Maryam Ezzati , Leila Roshangar, Jafar Soleimani, Nahid karimian   +3 more
doaj   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source