Results 81 to 90 of about 10,976 (205)

Hyaluronan Biosynthesis by Class I Streptococcal Hyaluronan Synthases Occurs at the Reducing End [PDF]

Journal of Biological Chemistry, 2005
Previous studies reached different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA) by addition to the reducing or the nonreducing end. Here we used two strategies to determine the direction of HA synthesis by purified class I HASs from Streptococcus equisimilis and Streptococcus pyogenes.
Valarie L, Tlapak-Simmons, Christina A, Baron, Russell, Gotschall, Dewan, Haque, William M, Canfield, Paul H, Weigel   +5 more
openaire   +2 more sources

TaqMan validation for co-culture versus pure culture for hyaluronan synthase (hasA), prolyl-tRNA synthase (proS), and cysteine protease (speB).

, 2013
TaqMan validation for co-culture versus pure culture for hyaluronan synthase (hasA), prolyl-tRNA synthase (proS), and cysteine protease (speB).
John P. Hays (405429), James M. Musser (33798), Anthony R. Flores (405428), Alex van Belkum (38419), Suzanne J. C. Verhaegh (405427)   +4 more
core   +1 more source

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases [PDF]

Journal of Biological Chemistry, 2007
Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct monosaccharides in different linkages and, in certain cases, participate in polymer transfer out of the cell.
Paul H, Weigel, Paul L, DeAngelis
openaire   +2 more sources

DS_10.1177_0022034519872478 – Supplemental material for Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development

, 2019
Supplemental material, DS_10.1177_0022034519872478 for Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development by Y. Lan, C. Qin and R.
R. Jiang (6502817), Y. Lan (6502811), C. Qin (6814784)   +2 more
core   +1 more source

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling after Arterial Ischemia

Cells, 2020
We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds.
Gangqi Wang, Margreet R. de Vries, Wendy M. P. J. Sol, Annemarie M. van Oeveren-Rietdijk, Hetty C. de Boer, Anton Jan van Zonneveld, Paul H. A. Quax, Ton J. Rabelink, Bernard M. van den Berg   +8 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

, 2023
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
NC DOCKS at East Carolina University, Wilson, Emily S., Litwa, Karen   +2 more
core  

Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion

Journal of Experimental & Clinical Cancer Research, 2016
Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing Jiang   +8 more
doaj   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source