Results 111 to 120 of about 10,976 (205)

Model of hyaluronan synthesis and export.

, 2013
The hyaluronan synthase assembles hyaluronan at the inner side of the plasma membrane, the chains are exported by the ABC transporter MRP5 from fibroblasts and retained on the cell surface by CD44.
Hermann Schillers (319915), Daniel Hagenfeld (319909), Tobias Schulz (319913), Udo Schumacher (149148), Peter Prehm (46903), Beatrice Borkenhagen (319911)   +5 more
core   +1 more source

Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis

International Journal of Polymer Science, 2019
The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure. Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy.
Gongbiao Lu, Lin Du, Jishou Lu, Liuzhong Jin   +3 more
doaj   +1 more source

Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells

, 2006
The functional consequences of increased renal cortical hyaluronan that is associated with both acute injury and progressive scarring are unclear. The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and determine ...
Csaba Fülöp, Fülöp, Csaba, Wisam Selbi, Carol A. de la Motte, Bowen, Timothy, Vincent C. Hascall, Aled O. Phillips, Rugg, Marilyn S., Timothy Bowen, Day, Anthony J.; id_orcid, Marilyn S. Rugg, De La Motte, Carol A., Phillips, Aled O., Hascall, Vincent C., Selbi, Wisam, Anthony J. Day   +15 more
core   +1 more source

Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy

Natural Products and Bioprospecting
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional Chinese medicine theory suggests the possibility of combining the two, however, the specific mechanisms involved have not been ...
Songtao Wu, Yingying Wang, Denghui Deng, Guohua Zheng, Hanxiang Mei, Cong Wang, Xiang Zheng, Chun Gui, Fei Liao, Meixian Xiang   +9 more
doaj   +1 more source

Decreased expression of hyaluronan synthase and loss of hyaluronan-rich cells in the anterior tibial fascia of the rat model of chemotherapy-induced peripheral neuropathy. [PDF]

Pain Rep, 2023
Wang R, Matsuoka Y, Sue N, Nakatsuka K, Tsuboi C, Morimatsu H.   +5 more
europepmc   +1 more source

Hyaluronan reduces migration and proliferation in CHO cells

, 2001
Expression of the hyaluronan synthase gene in hyaluronan-deficient CHO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form.
Dübe, Birgit, Hans Joachim Lüke, Aumailley, Monique, Prehm, Peter, Birgit Dübe, Lüke, Hans Joachim, Peter Prehm, Monique Aumailley   +7 more
core   +1 more source

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. [PDF]

Pediatr Res, 2022
Mayer CA, Ganguly A, Mayer A, Pabelick CM, Prakash YS, Hascall VC, Midura RJ, Cali V, Flask CA, Erokwu BO, Martin RJ, MacFarlane PM.   +11 more
europepmc   +1 more source

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan

, 2001
Hyaluronan is an abundant and rapidly turned over matrix molecule between the vital cell layers of the epidermis. In this study, epidermal growth factor (EGF) induced a coat of hyaluronan and a 3-5-fold increase in its rate of synthesis in a rat ...
Sironen, Reijo,, Tammi, Markku,, Fulop, Csaba,, Karvinen, Susanna,, Lammi, Mikko,, Pienimaki, Juha-Pekka,, Pasonen, Sanna,, Hascall, Vince,, Rilla, Kirsi,, Tammi, Raija,   +9 more
core   +1 more source

Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss. [PDF]

Clin Exp Otorhinolaryngol, 2022
Umugire A, Lee S, Lee CJ, Choi Y, Kim T, Cho HH.   +5 more
europepmc   +1 more source

An Engineered Hyaluronan Synthase [PDF]

Journal of Biological Chemistry, 2004
Hiroko Hoshi, Hiroaki Nakagawa, Susumu Nishiguchi, Kazumichi Iwata, Kenichi Niikura, Kenji Monde, Shin-Ichiro Nishimura   +6 more
openaire   +1 more source