Results 121 to 130 of about 10,976 (205)

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3. The low expression level of HASs in normal keratinocytes and other various types of cells presents a recognized challenge, impeding biological and pathological research on ...
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
openaire   +3 more sources

Hyaluronan Synthesis and Myogenesis: A requirement for hyaluronan synthesis during myogenic differentiation independent of pericullular matrix formation

, 2013
Background The role endogenously synthesized hyaluronan plays in myogenesis is not yet known.Results Hyaluronan synthase genes were expressed during skeletal muscle growth and regeneration; inhibiting these synthases prevents myoblast differentiation and
E Mackie (13710355), J White (7674893), Chris Kintakas (13064391), C Gorman (13710352), L Hunt (13700437), Daniel Mcculloch (13067379)   +5 more
core  

Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2

, 2013
Epithelial-mesenchymal transition (EMT) is a developmental program, which can be adopted by cancer cells to increase their migration and ability to form metastases. Transforming growth factor β (TGFβ) is a well-studied inducer of EMT. We demonstrate that
B Bernert, A D Theocharis, C-H Heldin, Porsch, Helena,, Heldin, Paraskevi,, Mehić, Merima,, Heldin, Carl-Henrik,, H Porsch, M Mehić, P Heldin, Bernert, Berit,, Theocharis, A D,   +11 more
core   +1 more source

Elevation of Hyaluronan Synthase by Magnesium Supplementation Mediated through the Activation of GSK3 and CREB in Human Keratinocyte-Derived HaCaT Cells. [PDF]

Int J Mol Sci, 2021
Marunaka K, Shu S, Kobayashi M, Goto M, Katsuta Y, Yoshino Y, Ikari A.   +6 more
europepmc   +1 more source

Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2. [PDF]

Sci Rep, 2021
Nazeri A, Niazi A, Afsharifar A, Taghavi SM, Moghadam A, Aram F.   +5 more
europepmc   +1 more source

Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. [PDF]

Exp Mol Med, 2022
Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E.   +7 more
europepmc   +1 more source

An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.

The Journal of biological chemistry, 2004
The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Hiroko, Hoshi, Hiroaki, Nakagawa, Susumu, Nishiguchi, Kazumichi, Iwata, Kenichi, Niikura, Kenji, Monde, Shin-Ichiro, Nishimura   +6 more
openaire   +1 more source

An Experimental study by Estimation of the Level of Hyaluronan Synthase in patients Suffering from Osteoarthritis of Knee, treated with Bryonia Alba

, 2018
Cases of Osteoarthritis with predefined symptoms of Bryonia alba have been taken up for the study by estimating the level of Hyaluronan synthase before and after treatment. AIMS AND OBJECTIVES: 1.
Aathira, V Nair
core  

Prognostic value of midkine, syndecan-1, hyaluronan synthase-2, sestrin-1, laminin subunit alpha-4 and fibulin-3 for malignant pleural mesothelioma. [PDF]

Arch Med Sci, 2023
Akgun H, Metintas S, Ak G, Demirkol Canlı S, Isbilen M, Gure AO, Metintas M.   +6 more
europepmc   +1 more source

Engineering Strategies for Hyaluronan Synthesis: A Review of Enzyme Modifications, Strain Selection, and Molecular Weight Control

Hyaluronan is a biopolymer with significant biological and commercial importance, particularly due to its applications in medical, cosmetic, and tissue engineering fields. The molecular weight of HA is a key factor that influences its biological function,
Ebrahimi, Tahereh, Abkhooie, Leila, Eivazi, Mortaza, Hosseini, Kamran, Tarhriz, Vahideh   +4 more
core   +1 more source