Results 131 to 140 of about 280,731 (250)

Identification of the Missing Protein Hyaluronan Synthase 1 in Human Mesenchymal Stem Cells Derived from Adipose Tissue or Umbilical Cord.

open access: yesJournal of Proteome Research, 2018
Currently, 14% of the human proteome is made up of proteins whose existence is not confirmed by mass spectrometry. We performed a proteomic profiling of human mesenchymal stem cells derived from adipose tissue or umbilical cord (PRIDE accession number ...
Luis Felipe Clemente   +6 more
semanticscholar   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

open access: yes, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping   +8 more
core   +1 more source

Identification of crucial genes for polycystic ovary syndrome and atherosclerosis through comprehensive bioinformatics analysis and machine learning

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 170, Issue 1, Page 312-325, July 2025.
Abstract Objective To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases in patients with PCOS.
Lirong Wang   +7 more
wiley   +1 more source

Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica)

open access: yesData in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya   +5 more
doaj  

Role of noncoding RNA in vascular remodelling [PDF]

open access: yes, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H.   +2 more
core   +1 more source

Effect of modulating the extracellular matrix cross linkage by genipin on tumor cell resistance and survival in thioacetamide-induced hepatocellular carcinoma in rats [PDF]

open access: yesPeerJ
Background Previous studies on patients and rats with hepatocellular carcinoma (HCC) have shown significant changes in the extracellular matrix (ECM). Versican, a component of the ECM, forms extensive multimolecular interactions with other ECM components,
Hanan M. Hassan   +10 more
doaj   +2 more sources

Hyaluronan Synthases [PDF]

open access: yesJournal of Biological Chemistry, 1997
P H, Weigel, V C, Hascall, M, Tammi
openaire   +2 more sources

Key Role of the Carboxyl Terminus of Hyaluronan Synthase in Processive Synthesis and Size Control of Hyaluronic Acid Polymers.

open access: yesBiomacromolecules, 2017
The essential pathophysiological roles of hyaluronic acid (HA) strongly depend on HA binding and HA size. Here we deployed the atomic vision of molecular dynamics (MD) simulation to experimentally investigate the influence of C-terminal mutations of ...
Ji Yang   +5 more
semanticscholar   +1 more source

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

open access: yesNeoplasia: An International Journal for Oncology Research, 2022
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules.
Tomohiro Seki   +10 more
doaj  

Cancer Microenvironment and Inflammation: Role of Hyaluronan [PDF]

open access: yes, 2015
The role of inflammation in the development of cancer was described as early as 19th century. Abundant evidence supports the preposition that various cancers are triggered by infection and chronic inflammatory disease whereas, evading immune destruction ...
Aikaterini Berdiaki   +4 more
core   +2 more sources

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