Mammalian Hyaluronan Synthases [PDF]
IUBMB Life, 2002 AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki Itano, Koji Kimata
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Diagnostic usefulness of Hyaluronan and Hyaluronan Synthases-A Review [PDF]
International Journal of Multidisciplinary and Current Research, 2018 The first isolation of HA was in the year 1934, but research on HA and its clinical significance in health and disease started only in the year 1970. Both HA and HASs play a significant role in many physiological and pathological processes. The cellular HA synthesis are coordinated collectively by HASs.
Dr.Oviya Senthilraj +3 more
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PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines [PDF]
, 2020 Hyaluronan (HA) is the major glycosaminoglycan component of the extracellular matrix in either normal or malignant tissues and it may affect proliferation, motility and differentiation of various cell types.
Gergely, Pál +8 more
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Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. [PDF]
Matrix Biol, 2016 Li Y +9 more
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Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. [PDF]
Arterioscler Thromb Vasc Biol, 2016 Kiene LS +15 more
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Quantitative continuous assay for hyaluronan synthase [PDF]
Analytical Biochemistry, 2007 A rapid, continuous, and convenient three-enzyme coupled UV absorption assay was developed to quantitate the glucuronic acid and N-acetylglucosamine transferase activities of hyaluronan synthase from Pasteurella multocida (PmHAS). Activity was measured by coupling the UDP produced from the PmHAS-catalyzed transfer of UDP-GlcNAc and UDP-GlcUA to a ...
Lianli Chi +7 more
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ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]
, 2017 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia +12 more
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An Engineered Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 2004 The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Kenji Monde +7 more
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Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]
, 2016 Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta +59 more
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Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]
, 2012 Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G. +3 more
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