Results 41 to 50 of about 279,632 (162)

Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2002
Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Tetsuya Sayo, Shingo Sakai, Yoshinori Sugiyama, Shintaro Inoue, Masaaki Tamura, Osamu Ishikawa, Yoshito Takahashi, Naoko Ozawa   +7 more
openaire   +3 more sources

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
Tomohiko Usui, F. Nakajima, Hideomi Yamashita, R. Ideta, Yasuyuki Suzuki, Makoto Araie, S. Miyauchi, Yuichi Kaji, Paraskevi Heldin   +8 more
openaire   +2 more sources

Hyaluronan: Biosynthesis and signaling [PDF]

, 2014
Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G., Deleonibus, S., Karousou, E., Passi, A., Vigetti, D., Viola, M.   +5 more
core   +1 more source

The control and importance of hyaluronan synthase expression in palatogenesis [PDF]

Frontiers in Physiology, 2013
Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation, and apoptosis. Palatal shelf elevation is considered to be driven by regional accumulation and hydration of glycosoaminoglycans, principally hyaluronan (HA), which provides an intrinsic shelf force ...
Galloway, Jennifer L, Jones, Sarah J, Mossey, Peter A, Ellis, Ian R   +3 more
openaire   +5 more sources

Hyaluronan Synthase 2

Definitions, 2020
Hyaluronan synthase 2 (552 aa, ~64 kDa) is encoded by the human HAS2 gene. This protein plays a role in the biosynthesis of hyaluronic acid.

semanticscholar   +1 more source

Immunohistochemical Analysis of IL-1 Receptor 1 In the Discs of Patients with Temporomandibular Joint Dysfunction [PDF]

, 2018
Objective Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR).
Almeida, Luis Eduardo, Bosio, Jose A, Butcher, Seth, Doetzer, Andrea, Hresko, Kyle, Leonardi, Rosalia, Lorento, Carla, Sorenson, Adam, Tayebi, Lobat   +8 more
core   +2 more sources

Dissecting the role of hyaluronan synthases in the tumor microenvironment [PDF]

The FEBS Journal, 2019
The tumor microenvironment is becoming a crucial factor in determining the aggressiveness of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of both the tumor stroma and the cancer cell surfaces, and its accumulation can dramatically influence patient survival.
Passi, Alberto, Vigetti, Davide, Buraschi, Simone, Iozzo, Renato V.   +3 more
openaire   +3 more sources

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms [PDF]

, 2016
Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic acid and N-acetylglucosamine.
Carvalho, Lucas Silva, Gomes, Antônio Milton Vieira, Magalhães, Beatriz Simas, Oliveira, Juliana Davies de, Parachin, Nádia Skorupa, Queiroz, Lúcio Rezende   +5 more
core   +2 more sources

Expression of hyaluronan synthases in articular cartilage

Osteoarthritis and Cartilage, 2000
To investigate the mRNA expression profiles of three mammalian hyaluronan synthases (HAS1, HAS2 and HAS3) in chondrocytes from normal (undiseased) animal cartilage and osteoarthritic human cartilage maintained in experimental culture systems and exposed to catabolic or anabolic stimuli provided by cytokines, growth factors and retinoic acid ...
D. R. R. Hiscock, Bruce Caterson, Carl R. Flannery   +2 more
openaire   +3 more sources

Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells [PDF]

, 2013
Thickening of the vessel in response to high low density lipoprotein(s) (LDL) levels is a hallmark of atherosclerosis, characterized by increased hyaluronan (HA) deposition in the neointima.
Bartolini, B., De Luca, G., Deleonibus, S., Hascall, V.C., Karousou, E., Moretto, P., Passi, A., Sawamura, T., Vigetti, D., Viola, M., Wight, T.N.   +10 more
core   +1 more source