Molecular Identification of a Putative Human Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 1996 To identify the putative mammalian hyaluronan synthase, we cloned a human cDNA that is related to the Streptococcus hyaluronan synthase (HasA) and the Xenopus developmental protein DG42 which has been shown to have chitin synthase activity. The cDNA, for which we propose the name Has2, encodes a novel protein with a predicted molecular mass of 63.6 kDa.
Yu Yamaguchi, Ken Watanabe
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Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis [PDF]
, 2011 Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated
B. Malle +15 more
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Hyaluronan Synthase Induction and Hyaluronan Accumulation in Mouse Epidermis Following Skin Injury [PDF]
Journal of Investigative Dermatology, 2005 Hyaluronan, a major extracellular matrix component in the epidermis, has been shown to control keratinocyte proliferation and differentiation in vitro. We assayed hyaluronan and hyaluronan synthases (has1-3) in mouse epidermis during fetal development, postnatal life, and trauma reaction in vivo. Hyaluronan increased in the epidermis when keratinocytes
Elina Kolehmainen +3 more
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The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]
, 2014 Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W. +8 more
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Functional Cloning of the cDNA for a Human Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 1996 Hyaluronan is a constituent of the extracellular matrix of connective tissue and is actively synthesized during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of hyaluronan are associated with inflammatory and degenerative arthropathies such as rheumatoid ...
Tadashi Yoshino +4 more
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Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep [PDF]
, 2017 An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising.
Fouladi-Nashta, A A +5 more
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HAS2 (hyaluronan synthase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
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Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance [PDF]
, 2015 The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle.
Christopher G. Faulkes +5 more
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Studies on the sperm reservoir of the pig oviduct [PDF]
, 2003 During sperm transport in the female pig a proportion of spermatozoa are arrested, often for 24 h or more, in a particular segment of the utero-tubal junction (UTJ) and the adjacent tubal isthmus, where a sperm reservoir (SR) is built up.
Tienthai, Paisan
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Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases [PDF]
Journal of Biological Chemistry, 2007 Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct monosaccharides in different linkages and, in certain cases, participate in polymer transfer out of the cell.
Paul L. DeAngelis, Paul H. Weigel
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