Results 51 to 60 of about 20,638 (257)

One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study. [PDF]

, 2013
Hypochlorous acid and its acid-base counterpart, hypochlorite ions, produced under inflammatory conditions, may produce chloramides of glycosaminoglycans, these being significant components of the extracellular matrix (ECM).
A.W.J. Paterson, Akeel, Al-Assaf, Al-Assaf, B.J. Parsons, Balazs, C. Houee-Levin, Camenisch, Chawla, D.J. Heyes, Dogliotti, Eriksen, Hardingham, Hawkins, Hayon, Hayon, Heckel, Heinecke, Huie, Ivanov, J.-L. Marignier, Jiang, Johnson, Kennett, Kennett, Kettle, Laurent, Laurent, McElroy, McElroy, McGowan, Milner, Misra, Parsons, Parsons, Pattison, Pattison, Pattison, Pe Myint, Poskrebyshev, Redpath, Rees, Rees, Rees, Rees, Rees, Rees, S. Sibanda, Schwarz, Stern, Swallow, Tang, Thomas, Thomas, Thorne, Toole, Toole, Toole, Turley, van Golen, von Sonntag, Weeks, Weiss, Weiss, Wine, Wolfenden, Woods, Zao   +67 more
core   +1 more source

Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica)

Data in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R.G.S. Wijesekara   +5 more
doaj   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +3 more sources

HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm

Heart International, 2009
The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular matrix molecule. Accumulating evidence emphasizes the relevance of HA metabolism in an increasing number of processes of clinical ...
Alberto Balbarini, Rossella Di Stefano, Marco Nuti, Stefano Landi, Chiara Armani   +4 more
doaj   +1 more source

CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque

JCI Insight, 2023
Vascular calcification (VC) is concomitant with atherosclerosis, yet it remains uncertain why rupture-prone high-risk plaques do not typically show extensive calcification.
Atsushi Sakamoto, Rika Kawakami, Masayuki Mori, Liang Guo, Ka Hyun Paek, Jose Verdezoto Mosquera, Anne Cornelissen, Saikat Kumar B. Ghosh, Kenji Kawai, Takao Konishi, Raquel Fernandez, Daniela T. Fuller, Weili Xu, Aimee E. Vozenilek, Yu Sato, Hiroyuki Jinnouchi, Sho Torii, Adam W. Turner, Hirokuni Akahori, Salome Kuntz, Craig C. Weinkauf, Parker J. Lee, Robert Kutys, Kathryn Harris, Alfred Lawrence Killey, Christina M. Mayhew, Matthew Ellis, Leah M. Weinstein, Neel V. Gadhoke, Roma Dhingra, Jeremy Ullman, Armella Dikongue, Maria E. Romero, Frank D. Kolodgie, Clint L. Miller, Renu Virmani, Aloke V. Finn   +36 more
doaj   +1 more source

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Neoplasia: An International Journal for Oncology Research, 2022
Purpose: PEGylated human hyaluronidase (PEGPH20) enzymatically depletes hyaluronan, an important component of the extracellular matrix, increasing the delivery of therapeutic molecules.
Tomohiro Seki, Yu Saida, Shun Kishimoto, Jisook Lee, Yasunori Otowa, Kazutoshi Yamamoto, Gadisetti VR Chandramouli, Nallathamby Devasahayam, James B. Mitchell, Murali C. Krishna, Jeffery R. Brender   +10 more
doaj   +1 more source

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells [PDF]

, 2014
Background Breast cancer\u2013endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the context of tumor perfusion and relatively little is known regarding the effects ...
Barbouri, D., Gialeli, C., Karamanos, N.K., Kletsas, D., Passi, A., Viola, M.   +5 more
core   +1 more source

Effect of red ginseng NaturalGEL on skin aging

Journal of Ginseng Research, 2020
Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim, Hye Rim Park, So Yoon Cha, So Hun Lee, Jung Wung Jo, Jung Nam Go, Kang Hyuk Lee, Su Yeon Lee, Song Seok Shin   +8 more
doaj   +1 more source

Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice

Frontiers in Immunology, 2022
HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Yoshiya Tsunoda, Kai Yazaki, Kazufumi Yoshida, Masayuki Nakajima, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa   +10 more
doaj   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source