Adhesive Properties of the Hyaluronan Pericellular Coat in Hyaluronan Synthases Overexpressing Mesenchymal Stem Cells [PDF]
International Journal of Molecular Sciences, 2020 Hyaluronan (HA), a natural component of the extracellular matrix, is supposed to have a regulatory function in the stem cell niche. Bone marrow-derived human mesenchymal stem cells (hMSCs) are known to express all three hyaluronan synthases (HASes), which are responsible for HA production.
Sebastian Reiprich +6 more
openaire +3 more sources
SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells [PDF]
, 2011 Background: Severe Acute Respiratory Syndrome (SARS) is characterized by acute respiratory distress (ARDS) and pulmonary fibrosis, and the monocyte/macrophage is the key player in the pathogenesis of SARS. Methods: In this study, we ...
Betty A. Wu-Hsieh +4 more
core +1 more source
Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]
, 2013 © 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P +8 more
core +2 more sources
Hyaluronan Biosynthesis by Class I Streptococcal Hyaluronan Synthases Occurs at the Reducing End [PDF]
Journal of Biological Chemistry, 2005 Previous studies reached different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA) by addition to the reducing or the nonreducing end. Here we used two strategies to determine the direction of HA synthesis by purified class I HASs from Streptococcus equisimilis and Streptococcus pyogenes.
Christina A. Baron +5 more
openaire +3 more sources
Hyaluronan is crucial for stem cell differentiation into smooth muscle lineage [PDF]
, 2016 Deciphering the extracellular signals that regulate SMC differentiation from stem cells is vital to further our understanding of the pathogenesis of vascular disease and for development of cell-based therapies and tissue engineering.
Abhold +59 more
core +1 more source
Mediators of Inflammation and Their Effect on Resident Renal Cells: Implications in Lupus Nephritis [PDF]
, 2013 published_or_final_versio
Chan, DTM +3 more
core +1 more source
In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila [PDF]
Journal of Biological Chemistry, 2004 Hyaluronan (HA) is a large linear polymer of repeating disaccharides of glucuronic acid and GlcNAc. Although HA is widely distributed in vertebrate animals, it has not been found in invertebrates, including insect species. Insects utilize chitin, a repeating beta-1,4-linked homopolymer of GlcNAc, as a major component of their exoskeleton.
Naoki Itano +8 more
openaire +3 more sources
Matrix Biology Plus, 2021 The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays a critical role in T1D pathogenesis, as spontaneous disease is blocked in mice fed the HA synthesis inhibitor 4-methylumbelliferone (4MU). The present study demonstrates the involvement of HA in
Paul L. Bollyky +6 more
openaire +3 more sources
Differential Virulence Gene Expression of Group A Streptococcus Serotype M3 in Response to Co-Culture with Moraxella catarrhalis [PDF]
, 2013 Streptococcus pyogenes (group A Streptococcus, GAS) and Moraxella catarrhalis are important colonizers and (opportunistic) pathogens of the human respiratory tract.
A Vergison +50 more
core +3 more sources
American Journal of Physiology - Cell Physiology, 2018 MicroRNAs (miRNAs) have been established as important regulators of gene expression in the mammalian ovary. A previous screen of small RNA in the porcine ovary identified the downregulation of miR-574 during oocyte maturation, although its role during ...
Bo Pan, Derek Toms, Julang Li
semanticscholar +1 more source