Results 71 to 80 of about 20,638 (257)

Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms [PDF]

, 2016
Hyaluronic acid, or HA, is a rigid and linear biopolymer belonging to the class of the glycosaminoglycans, and composed of repeating units of the monosaccharides glucuronic acid and N-acetylglucosamine.
Carvalho, Lucas Silva, Gomes, Antônio Milton Vieira, Magalhães, Beatriz Simas, Oliveira, Juliana Davies de, Parachin, Nádia Skorupa, Queiroz, Lúcio Rezende   +5 more
core   +2 more sources

Hyaluronan Synthase Induction and Hyaluronan Accumulation in Mouse Epidermis Following Skin Injury [PDF]

Journal of Investigative Dermatology, 2005
Hyaluronan, a major extracellular matrix component in the epidermis, has been shown to control keratinocyte proliferation and differentiation in vitro. We assayed hyaluronan and hyaluronan synthases (has1-3) in mouse epidermis during fetal development, postnatal life, and trauma reaction in vivo. Hyaluronan increased in the epidermis when keratinocytes
Tammi, Raija, Pasonen-Seppänen, Sanna, Kolehmainen, Elina, Tammi, Markku   +3 more
openaire   +2 more sources

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model

International Journal of Cell Biology, 2015
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the ...
Sean P. Kessler, Dana R. Obery, Carol de la Motte   +2 more
doaj   +1 more source

A structural and biochemical model of processive chitin synthesis [PDF]

, 2014
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach, Atkinson, Barny, Bond, Bowen, Cabib, Charnock, Coutinho, D'Haeze, Daan M.F. van Aalten, Debellé, Drew, Gaughran, Helge C. Dorfmueller, Imai, Kamst, Kamst, Kamst, Karnezis, Kathiravan, Källberg, Manoil, Martínez-Rucobo, Masubuchi, Mavingui, Morgan, Nagahashi, Orlean, Rao, Ruiz-Herrera, Semino, Shaw, Streng, Sudoh, Thompson, Uchida, Vladimir S. Borodkin, Xie, Yabe   +38 more
core   +3 more sources

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis [PDF]

, 2011
Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated
B. Malle, Baccarani-Contri M, Bhattacharya J, G. Gauglitz, G. Schmitz, H.C. Korting, K. Schwach-Abdellaoui, M. Farwick, M. Wegmann, Mehul B, Noble PW, T. Köhler, T. Pavicic, Turino GM, V. Tarabin, Weigel PH   +15 more
core   +2 more sources

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review

International Journal of Dermatology, EarlyView.
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Marie‐Eline Pauline Henriette Debeuf, Maartje Hendrika Pieternel Rauwenhoff, Michel van Geel, Peter Martin Steijlen, Valerie Lydie Roland Marc Verstraeten   +4 more
wiley   +1 more source

The Control and Importance of Hyaluronan Synthase Expression in Palatogenesis

Frontiers in Physiology, 2013
Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation and apoptosis.
Jennifer eGalloway, Sarah eJones, Peter eMossey, Ian eEllis   +3 more
doaj   +1 more source

Studies on the sperm reservoir of the pig oviduct [PDF]

, 2003
During sperm transport in the female pig a proportion of spermatozoa are arrested, often for 24 h or more, in a particular segment of the utero-tubal junction (UTJ) and the adjacent tubal isthmus, where a sperm reservoir (SR) is built up.
Tienthai, Paisan
core