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Role of UDP-GlcNAc and hyaluronan synthase 2 O-GlcNAcylation in the control of hyaluronan synthesis.
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Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis
Biochemical and Biophysical Research Communications, 2020Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblasts and found that TPA and 4-MU have
Kosuke Kasai +2 more
exaly +3 more sources
Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity [PDF]
Experimental Cell Research, 2005 Osteosarcoma is a common malignant bone tumor associated with childhood and adolescence. The results of numerous studies have suggested that hyaluronan plays an important role in regulating the aggressive behavior of various types of cancer cells. However, no studies have addressed hyaluronan with respect to osteosarcomas.
Yoshihiro Nishida +2 more
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Delivery of a vector encoding mouse hyaluronan synthase 2 via a crosslinked hyaluronan film
Biomaterials, 2005We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Analysis of the DNA release kinetics indicated that the HA films degraded when treated with hyaluronidase and that ...
Angela P, Kim +4 more
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Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy
Medical Hypotheses, 2007Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment.
Da-Wei, Zhang +5 more
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Cellular Signalling, 2019
Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated signaling cascades lead to follicular development, oocyte maturation, and ovulation. Transforming growth factor-β (TGF-β1) is highly expressed in human oocytes and granulosa cells and involved in the regulation of follicular development and ovulation.
Fuxin Wang +4 more
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Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated signaling cascades lead to follicular development, oocyte maturation, and ovulation. Transforming growth factor-β (TGF-β1) is highly expressed in human oocytes and granulosa cells and involved in the regulation of follicular development and ovulation.
Fuxin Wang +4 more
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2002
Hyaluronan (HA) is a major component of the extracellular and pericellular matrix. It is a simple, linear glycosaminoglycan composed of thousands of disaccharide repeats of glucuronic acid and N-acetylglucosamine [1].Initially isolated from the vitreous humor, this macromolecule can be found in numerous tissues and body fluids of vertebrates, as well ...
Janet Y. Lee +3 more
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Hyaluronan (HA) is a major component of the extracellular and pericellular matrix. It is a simple, linear glycosaminoglycan composed of thousands of disaccharide repeats of glucuronic acid and N-acetylglucosamine [1].Initially isolated from the vitreous humor, this macromolecule can be found in numerous tissues and body fluids of vertebrates, as well ...
Janet Y. Lee +3 more
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Hyaluronan Synthase-1, -2, and -3
2002Hyaluronan (HA) is a high-molecular-weight linear polysaccharide composed of β-1,4-linked repeating disaccharides of glucuronic acid β-1,3-linked to N- acetylglucosamine. It is found in the extracellular matrices of most vertebrate tissues and in the capsules of certain bacterial pathogens.
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Inhibition of Hyaluronan Synthase 2 Reduces the Abnormal Migration Rate of Keloid Keratinocytes
Journal of Burn Care & Research, 2014Keloids are fibroproliferative scars that spread beyond the original wound boundary and are very resistant to treatment. Development of highly effective therapies requires a comprehensive understanding of the mechanisms regulating keloid formation.
Dorothy M, Supp +3 more
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