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Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance
Histopathology, 2014Hyaluronan synthase 2 (HAS2) is an enzyme in hyaluronan synthesis. Several studies have demonstrated that HAS2 plays a critical role in tumour progression in breast cancer cells. The in-situ expression patterns of HAS2 remain unclear, and the aim of this study was to determine these in order to elucidate the role of HAS2 in breast cancer.We examined ...
Huang-Chun, Lien +5 more
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Experimental Cell Research, 2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and spreading. 4-Methylumbelliferone (4-MU) inhibits hyaluronan synthesis and retards cancer spreading in experimental animals through mechanisms not fully understood.
Anne, Kultti +7 more
openaire +2 more sources
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and spreading. 4-Methylumbelliferone (4-MU) inhibits hyaluronan synthesis and retards cancer spreading in experimental animals through mechanisms not fully understood.
Anne, Kultti +7 more
openaire +2 more sources
Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions
Frontiers in Immunology, 2015Hanna Siiskonen +2 more
exaly