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Delivery of a vector encoding mouse hyaluronan synthase 2 via a crosslinked hyaluronan film
Biomaterials, 2005We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Analysis of the DNA release kinetics indicated that the HA films degraded when treated with hyaluronidase and that ...
Angela P, Kim +4 more
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Cellular Signalling, 2019
Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated signaling cascades lead to follicular development, oocyte maturation, and ovulation. Transforming growth factor-β (TGF-β1) is highly expressed in human oocytes and granulosa cells and involved in the regulation of follicular development and ovulation.
Fuxin Wang +4 more
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Hyaluronan serves as a structural component of ovarian follicles, and hyaluronan-mediated signaling cascades lead to follicular development, oocyte maturation, and ovulation. Transforming growth factor-β (TGF-β1) is highly expressed in human oocytes and granulosa cells and involved in the regulation of follicular development and ovulation.
Fuxin Wang +4 more
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Amelioration of osteoarthritis by intra-articular hyaluronan synthase 2 gene therapy
Medical Hypotheses, 2007Osteoarthritis (OA) is a chronic, degenerative disorder of multifactorial aetiology, characterized by loss of articular cartilage and periarticular bone remodelling. Goals of managing OA include controlling pain, maintaining and improving function and health-related quality of life, and limiting functional impairment.
Da-Wei, Zhang +5 more
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Abstract A056: Epithelial hyaluronan synthase 2 expression promotes pancreas cancer metastasis
Cancer Research, 2022Abstract A defining characteristic of pancreatic ductal adenocarcinoma (PDA) is its robust desmoplastic reaction that promotes tumor progression and protects PDA from treatment. As a major component of the extreme microenvironment, hyaluronan (HA) is synthesized by the hyaluronan synthase (Has) family of enzymes and secreted in excess by
Bo Tu +6 more
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Hyaluronan Synthase-1, -2, and -3
2002Hyaluronan (HA) is a high-molecular-weight linear polysaccharide composed of β-1,4-linked repeating disaccharides of glucuronic acid β-1,3-linked to N- acetylglucosamine. It is found in the extracellular matrices of most vertebrate tissues and in the capsules of certain bacterial pathogens.
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2002
Hyaluronan (HA) is a major component of the extracellular and pericellular matrix. It is a simple, linear glycosaminoglycan composed of thousands of disaccharide repeats of glucuronic acid and N-acetylglucosamine [1].Initially isolated from the vitreous humor, this macromolecule can be found in numerous tissues and body fluids of vertebrates, as well ...
Janet Y. Lee +3 more
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Hyaluronan (HA) is a major component of the extracellular and pericellular matrix. It is a simple, linear glycosaminoglycan composed of thousands of disaccharide repeats of glucuronic acid and N-acetylglucosamine [1].Initially isolated from the vitreous humor, this macromolecule can be found in numerous tissues and body fluids of vertebrates, as well ...
Janet Y. Lee +3 more
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Interleukin-1 Beta Mediated Regulation of Hyaluronan and Hyaluronan Synthase 2
2005VCU Theses and ...
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Inhibition of Hyaluronan Synthase 2 Reduces the Abnormal Migration Rate of Keloid Keratinocytes
Journal of Burn Care & Research, 2014Keloids are fibroproliferative scars that spread beyond the original wound boundary and are very resistant to treatment. Development of highly effective therapies requires a comprehensive understanding of the mechanisms regulating keloid formation.
Dorothy M, Supp +3 more
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Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance
Histopathology, 2014Hyaluronan synthase 2 (HAS2) is an enzyme in hyaluronan synthesis. Several studies have demonstrated that HAS2 plays a critical role in tumour progression in breast cancer cells. The in-situ expression patterns of HAS2 remain unclear, and the aim of this study was to determine these in order to elucidate the role of HAS2 in breast cancer.We examined ...
Huang-Chun, Lien +5 more
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Phytomedicine
Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic and endocrine disorder that causes anovulatory infertility and abnormal folliculogenesis in women of reproductive age. Several studies have revealed inflammation in PCOS follicles, and recent evidence suggests that Berberine (BBR) effectively reduces inflammatory responses in PCOS, however ...
Shaojing He +11 more
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Polycystic ovary syndrome (PCOS) is a heterogeneous metabolic and endocrine disorder that causes anovulatory infertility and abnormal folliculogenesis in women of reproductive age. Several studies have revealed inflammation in PCOS follicles, and recent evidence suggests that Berberine (BBR) effectively reduces inflammatory responses in PCOS, however ...
Shaojing He +11 more
openaire +2 more sources