Results 131 to 140 of about 10,002 (164)

Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response

Matrix Biology, 2022
Dysregulated extracellular matrix (ECM) is a hallmark of adverse cardiac remodeling after myocardial infarction (MI). Previous work from our laboratory suggests that synthesis of the major ECM component hyaluronan (HA) may be beneficial for post-infarct healing.
Marco Piroth, Daniel J Gorski, Christian Hundhausen, Anne Petz, Simone Gorressen, Dominik Semmler, Heba Zabri, Sonja Hartwig, Stefan Lehr, Malte Kelm, Christian Jung, Jens W. Fischer   +11 more
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Molecular cloning, genomic organization and developmental expression of the Xenopus laevis hyaluronan synthase 3

Matrix Biology, 2003
The content of hyaluronan (HA), a polymer of the extracellular matrix involved in a variety of physiological and pathological processes, depends on the activity of synthetic (HAS) and degrading enzymes. Since HA is also involved in embryogenesis, we have used Xenopus as a model organism because information is available for HAS1 and HAS2, but not for ...
VIGETTI, DAVIDE, VIOLA, MANUELA, E. CEREDA, GORNATI, ROSALBA, KAROUSOU, EVGENIA, BERNARDINI, GIOVANNI BATTISTA, PASSI, ALBERTO, DE LUCA, GIANCARLO   +7 more
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Inhibition of Hyaluronan Synthase-3 Decreases Subcutaneous Colon Cancer Growth in Mice

Diseases of the Colon & Rectum, 2010
Hyaluronan and hyaluronan synthases have been implicated in cancer progression. Hyaluronan synthase-3 is up-regulated in metastatic colon cancer cells (SW620), and its expression mediates cellular growth in vitro. We hypothesized that inhibition of hyaluronan synthase-3 would decrease tumor formation and/or alter the pattern of metastasis in mouse ...
Eric, Lai, Rahul, Singh, Brian, Teng, Yali, Zhao, Elizabeth, Sharratt, Gillian, Howell, Ashwani, Rajput, Kelli, Bullard Dunn   +7 more
openaire   +2 more sources

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

Experimental Cell Research, 2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and spreading. 4-Methylumbelliferone (4-MU) inhibits hyaluronan synthesis and retards cancer spreading in experimental animals through mechanisms not fully understood.
Anne, Kultti, Sanna, Pasonen-Seppänen, Marjo, Jauhiainen, Kirsi J, Rilla, Riikka, Kärnä, Emma, Pyöriä, Raija H, Tammi, Markku I, Tammi   +7 more
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Hyaluronan Synthase-1, -2, and -3

2002
Hyaluronan (HA) is a high-molecular-weight linear polysaccharide composed of β-1,4-linked repeating disaccharides of glucuronic acid β-1,3-linked to N- acetylglucosamine. It is found in the extracellular matrices of most vertebrate tissues and in the capsules of certain bacterial pathogens.
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Hyaluronan synthase 3 (HAS3) overexpression downregulates MV3 melanoma cell proliferation, migration and adhesion

Experimental Cell Research, 2015
Malignant skin melanoma is one of the most deadly human cancers. Extracellular matrix (ECM) influences the growth of malignant tumors by modulating tumor cells adhesion and migration. Hyaluronan is an essential component of the ECM, and its amount is altered in many tumors, suggesting an important role for hyaluronan in tumorigenesis.
Ropponen Antti, Bart Genevieve, Rilla Kirsi, Tammi Markku, Takabe Piia, Tammi Raija, Pasonen-Seppänen Sanna   +6 more
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Abstract 554: Vascular Lesion Formation is Attenuated by Genetic Deletion of Hyaluronan Synthase 3

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
An extensive accumulation of the matrix component hyaluronan (HA) has been observed in vascular lesions. HA is thought to confer immunomodulatory actions and to regulate cell proliferation and migration in diseased vessels. HA is extruded into the extracellular space by three transmembrane HA-synthase isoenzymes (HAS1, -2, -3).
Lena S Dick, Susanne Homann, Julia Mueller, Maria Grandoch, Jens W Fischer   +4 more
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Abstract 4844: Extracellular hyaluronan accumulation by hyaluronan synthase 3 promotes pancreatic cancer growth and modulates tumor microenvironment via epithelial-mesenchymal transition

Cancer Research, 2014
Abstract Pancreatic cancer is one of most deadly cancers with a 5-year survival rate of 6%. Accumulation of hyaluronan (HA) is found in about 87% of human pancreatic adenocarcinomas, and removal of HA suppresses tumor growth in HA-rich preclinical models. In a transgenic pancreatic cancer mouse model (LSL-KrasG12D/+;LSLTrp53R172H/+;Pdx-1-
Anne Kultti, Chunmei Zhao, Susan Zimmerman, Ryan J. Osgood, Yanling Chen, Rebecca Symons, Ping Jiang, Curtis B. Thompson, David A. Tuveson, Gregory I. Frost, H Michael Shepard, Zhongdong Huang   +11 more
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Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival

Breast Cancer Research and Treatment, 2013
Accumulation of hyaluronan (HA) in pericellular stroma and carcinoma cells is predictive of unfavorable patient prognosis in many epithelial cancers. However, it is not known whether the HA originates from carcinoma or stromal cells, or whether increased expression of hyaluronan synthase proteins (HAS1-3) contributes to HA accumulation.
Päivi, Auvinen, Kirsi, Rilla, Ritva, Tumelius, Markku, Tammi, Reijo, Sironen, Ylermi, Soini, Veli-Matti, Kosma, Arto, Mannermaa, Jukka, Viikari, Raija, Tammi   +9 more
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Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

Cancer research, 2001
Hyaluronan synthase 3 (HAS3) is responsible for the production of both secreted and cell-associated forms of hyaluronan and is the most active of the three isoforms of this enzyme in adults. In this study, the cDNA for human HAS3 was cloned and characterized.
N, Liu, F, Gao, Z, Han, X, Xu, C B, Underhill, L, Zhang   +5 more
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