Results 181 to 190 of about 87,553 (215)
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Experimental Cell Research, 2015
Malignant skin melanoma is one of the most deadly human cancers. Extracellular matrix (ECM) influences the growth of malignant tumors by modulating tumor cells adhesion and migration. Hyaluronan is an essential component of the ECM, and its amount is altered in many tumors, suggesting an important role for hyaluronan in tumorigenesis.
P. Takabe +6 more
semanticscholar +3 more sources
Malignant skin melanoma is one of the most deadly human cancers. Extracellular matrix (ECM) influences the growth of malignant tumors by modulating tumor cells adhesion and migration. Hyaluronan is an essential component of the ECM, and its amount is altered in many tumors, suggesting an important role for hyaluronan in tumorigenesis.
P. Takabe +6 more
semanticscholar +3 more sources
Expression of hyaluronan synthase-3 in porcine oviducal epithelium during oestrus.
Reproduction, Fertility and Development, 2003Hyaluronan (HA) has been related to fertilization and embryo development in the pig. Furthermore, HA is present in pig oviduct fluid and the lining epithelium, particularly of the pre-ovulatory sperm reservoir. Because the mechanisms that regulate HA synthesis have not yet been clarified, semiquantitative reverse transcription-polymerase chain reaction
P. Tienthai +4 more
semanticscholar +3 more sources
ToxicologyCadmium is a heavy metal risk factor for various cardiovascular diseases, such as atherosclerosis. In atherosclerotic lesions, hyaluronan, a glycosaminoglycan consisting of β4-glucuronic acid-β3-N-acetylglucosamine disaccharides repeats, is highly accumulated, regulating signal transduction, cell migration, and angiogenesis.
Misaki Shirai +3 more
semanticscholar +3 more sources
Hyaluronan And Hyaluronan Synthase-3 Mediate FAK Expression And Activation In Colon Cancer Cells
Journal of Surgical Research, 2011M. Heffler +5 more
semanticscholar +2 more sources
Matrix Biology, 2003
The content of hyaluronan (HA), a polymer of the extracellular matrix involved in a variety of physiological and pathological processes, depends on the activity of synthetic (HAS) and degrading enzymes. Since HA is also involved in embryogenesis, we have used Xenopus as a model organism because information is available for HAS1 and HAS2, but not for ...
D. Vigetti +7 more
semanticscholar +7 more sources
The content of hyaluronan (HA), a polymer of the extracellular matrix involved in a variety of physiological and pathological processes, depends on the activity of synthetic (HAS) and degrading enzymes. Since HA is also involved in embryogenesis, we have used Xenopus as a model organism because information is available for HAS1 and HAS2, but not for ...
D. Vigetti +7 more
semanticscholar +7 more sources
Inhibition of Hyaluronan Synthase-3 Decreases Subcutaneous Colon Cancer Growth in Mice
Diseases of the Colon & Rectum, 2010Hyaluronan and hyaluronan synthases have been implicated in cancer progression. Hyaluronan synthase-3 is up-regulated in metastatic colon cancer cells (SW620), and its expression mediates cellular growth in vitro. We hypothesized that inhibition of hyaluronan synthase-3 would decrease tumor formation and/or alter the pattern of metastasis in mouse ...
E. Lai +7 more
semanticscholar +3 more sources
Cancer Research, 2014
Abstract Pancreatic cancer is one of most deadly cancers with a 5-year survival rate of 6%. Accumulation of hyaluronan (HA) is found in about 87% of human pancreatic adenocarcinomas, and removal of HA suppresses tumor growth in HA-rich preclinical models. In a transgenic pancreatic cancer mouse model (LSL-KrasG12D/+;LSLTrp53R172H/+;Pdx-1-
Anne Kultti +11 more
semanticscholar +2 more sources
Abstract Pancreatic cancer is one of most deadly cancers with a 5-year survival rate of 6%. Accumulation of hyaluronan (HA) is found in about 87% of human pancreatic adenocarcinomas, and removal of HA suppresses tumor growth in HA-rich preclinical models. In a transgenic pancreatic cancer mouse model (LSL-KrasG12D/+;LSLTrp53R172H/+;Pdx-1-
Anne Kultti +11 more
semanticscholar +2 more sources
Inhibition of Hyaluronan Synthase-3 Decreases Subcutaneous Tumor Growth by Increasing Apoptosis
Journal of Surgical Research, 2010Brian P Teng +4 more
semanticscholar +2 more sources
Experimental Cell Research, 2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and spreading. 4-Methylumbelliferone (4-MU) inhibits hyaluronan synthesis and retards cancer spreading in experimental animals through mechanisms not fully understood.
Anne, Kultti +7 more
openaire +2 more sources
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and spreading. 4-Methylumbelliferone (4-MU) inhibits hyaluronan synthesis and retards cancer spreading in experimental animals through mechanisms not fully understood.
Anne, Kultti +7 more
openaire +2 more sources
Hyaluronan Synthase-1, -2, and -3
2002Hyaluronan (HA) is a high-molecular-weight linear polysaccharide composed of β-1,4-linked repeating disaccharides of glucuronic acid β-1,3-linked to N- acetylglucosamine. It is found in the extracellular matrices of most vertebrate tissues and in the capsules of certain bacterial pathogens.
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