Results 1 to 10 of about 2,588 (196)

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells [PDF]

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3.
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
doaj   +5 more sources

Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets [PDF]

Matrix Biology Plus, 2021
The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D).
John A. Gebe, Michel D. Gooden, Gail Workman, Nadine Nagy, Paul L. Bollyky, Thomas N. Wight, Robert B. Vernon   +6 more
doaj   +4 more sources

Expression and molecular characterization of an intriguing hyaluronan synthase (HAS) from the symbiont “Candidatus Mycoplasma liparidae” in snailfish [PDF]

PeerJ
Background Hyaluronan synthases (HASs) are ubiquitous in living organisms, and the hyaluronic acid (HA) synthesized by them are important to their body and well used in medicine, cosmetics and other fields.
Lulu Guo, Shaolu Wang, Chunang Lian, Lisheng He   +3 more
doaj   +4 more sources

Dissecting the role of hyaluronan synthases in the tumor microenvironment. [PDF]

FEBS J, 2019
The tumor microenvironment is becoming a crucial factor in determining the aggressiveness of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of both the tumor stroma and the cancer cell surfaces, and its accumulation can dramatically influence patient survival.
Passi A, Vigetti D, Buraschi S, Iozzo RV.   +3 more
europepmc   +6 more sources

Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis [PDF]

Brazilian Journal of Medical and Biological Research, 2015
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia,
V.K. de Sá, T.P. Rocha, AL. Moreira, F.A. Soares, T. Takagaki, L. Carvalho, A.G. Nicholson, V.L. Capelozzi   +7 more
doaj   +4 more sources

Hyaluronan accumulation is associated with reduced hyaluronidase expression in renal cell carcinoma, with CD44, HAS1, and HYAL2 emerging as prognostic markers. [PDF]

J Pathol Clin Res
Abstract Hyaluronan (HA), a large extracellular matrix glycosaminoglycan, is associated with malignant features in several human cancers. The accumulation of HA in renal cell carcinomas (RCC) correlates with unfavorable outcomes, higher tumor grade, and more advanced disease stages.
Jokelainen O, Rintala T, Remes S, Pasonen-Seppänen S, Nykopp TK, Sironen R.   +5 more
europepmc   +2 more sources

SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study [PDF]

mBio
We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences
Urban Hellman, Ebba Rosendal, Joakim Lehrstrand, Johan Henriksson, Tove Björsell, Alfred Wennemo, Max Hahn, Björn Österberg, Luiza Dorofte, Emma Nilsson, Mattias N. E. Forsell, Anna Smed-Sörensen, Anna Lange, Mats G. Karlsson, Clas Ahlm, Anders Blomberg, Sara Cajander, Ulf Ahlgren, Alicia Lind, Johan Normark, Anna K. Överby, Annasara Lenman   +21 more
doaj   +2 more sources

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
doaj   +2 more sources

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model [PDF]

Current Issues in Molecular Biology
Skin radiance is crucial for enhancing facial attractiveness and is negatively affected by factors like hyperpigmentation and aging-related changes. Current treatments often lack comprehensive solutions for improving skin radiance.
Hyeyeon Chun, Hyejin Lee, Jongwook Kim, Hyerin Yeo, Kyongeun Hyung, Dayoung Song, Moonju Kim, Seung-Hyun Jun, Nae-Gyu Kang   +8 more
doaj   +2 more sources

Potential Skin Health Benefits of Abalone By-Products Suggested by Their Effects on MAPKS and PI3K/AKT/NF-kB Signaling Pathways in HDF and HaCaT Cells [PDF]

Foods
Abalone, a marine edible gastropod with nutritional value, is a popular seafood delicacy worldwide, especially in Asia; however, viscera by-products are generally discarded during processing. Therefore, we investigated the skin health benefits of abalone
Eun-A Kim, Nalae Kang, Jun-Ho Heo, Areumi Park, Seong-Yeong Heo, Chang-Ik Ko, Yong-Seok Ahn, Ginnae Ahn, Soo-Jin Heo   +8 more
doaj   +2 more sources