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Metabolic control of hyaluronan synthases [PDF]

Matrix Biology, 2014
Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology ...
De Luca G., Karousou E., Passi A., Vigetti D., Viola M.   +4 more
core   +5 more sources

Structure, substrate recognition and initiation of hyaluronan synthase [PDF]

Nature, 2022
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Jeremi Kuklewicz, Robin A Corey, Ruoya Ho   +2 more
exaly   +7 more sources

Expression and molecular characterization of an intriguing hyaluronan synthase (HAS) from the symbiont “Candidatus Mycoplasma liparidae” in snailfish [PDF]

PeerJ
Background Hyaluronan synthases (HASs) are ubiquitous in living organisms, and the hyaluronic acid (HA) synthesized by them are important to their body and well used in medicine, cosmetics and other fields.
Lulu Guo, Shaolu Wang, Chunang Lian, Lisheng He   +3 more
doaj   +4 more sources

Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets [PDF]

Matrix Biology Plus, 2021
The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D).
John A. Gebe, Michel D. Gooden, Gail Workman, Nadine Nagy, Paul L. Bollyky, Thomas N. Wight, Robert B. Vernon   +6 more
doaj   +2 more sources

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content [PDF]

BMC Cancer, 2009
Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis.
Heikkinen Anna-Mari, Hämäläinen Kirsi, Tammi Raija H, Tammi Markku I, Sironen Reijo, Rilla Kirsi, Nykopp Timo K, Komulainen Marja, Kosma Veli-Matti, Anttila Maarit   +9 more
doaj   +2 more sources

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells [PDF]

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3.
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
doaj   +2 more sources

Quantitative continuous assay for hyaluronan synthase [PDF]

Analytical Biochemistry, 2006
A rapid, continuous, and convenient three-enzyme coupled UV absorption assay was developed to quantitate the glucuronic acid and N-acetylglucosamine transferase activities of hyaluronan synthase from Pasteurella multocida (PmHAS). Activity was measured by coupling the UDP produced from the PmHAS-catalyzed transfer of UDP-GlcNAc and UDP-GlcUA to a ...
Joanne C. Krupa, David Shaya, Lianli Chi, Robert J. Linhardt, Mirosław Cygler, Stephen G. Withers, John S. Mort   +6 more
openalex   +5 more sources

Unvaporized e-liquid toxicity elevates CD44-dependent hyaluronan catabolic gene expression and triggers inflammation in human vocal fold fibroblasts [PDF]

Toxicology Reports
Electronic (e)-cigarette and e-liquid exposure have been linked to vocal fold inflammation and dysphonia, yet no targeted non-surgical therapies currently exist. Hyaluronan, a key extracellular matrix component essential for vocal fold structure, repair,
Kaustuv Basu, James Li, Luc Mongeau
doaj   +2 more sources

Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis [PDF]

Brazilian Journal of Medical and Biological Research, 2015
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia,
V.K. de Sá, T.P. Rocha, AL. Moreira, F.A. Soares, T. Takagaki, L. Carvalho, A.G. Nicholson, V.L. Capelozzi   +7 more
doaj   +4 more sources

Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema [version 1; peer review: 2 approved] [PDF]

F1000Research
This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE).
Masamoto Murakami, Jun Muto, Kazuki Yatsuzuka   +2 more
doaj   +2 more sources