Results 1 to 10 of about 263,699 (217)

Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets [PDF]

Matrix Biology Plus, 2021
The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D).
John A. Gebe, Michel D. Gooden, Gail Workman, Nadine Nagy, Paul L. Bollyky, Thomas N. Wight, Robert B. Vernon   +6 more
doaj   +5 more sources

Dissecting the role of hyaluronan synthases in the tumor microenvironment. [PDF]

FEBS J, 2019
The tumor microenvironment is becoming a crucial factor in determining the aggressiveness of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of both the tumor stroma and the cancer cell surfaces, and its accumulation can dramatically influence patient survival.
Passi A, Vigetti D, Buraschi S, Iozzo RV.   +3 more
europepmc   +7 more sources

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells [PDF]

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3.
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
doaj   +4 more sources

Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis [PDF]

Brazilian Journal of Medical and Biological Research, 2015
We collected a series of 136 lung/bronchial and 56 matched lung parenchyma tissue samples from patients who underwent lung/bronchial biopsies and presented invasive carcinoma after lung surgery. The lung/bronchial samples included basal cell hyperplasia,
V.K. de Sá, T.P. Rocha, AL. Moreira, F.A. Soares, T. Takagaki, L. Carvalho, A.G. Nicholson, V.L. Capelozzi   +7 more
doaj   +6 more sources

Adhesive Properties of the Hyaluronan Pericellular Coat in Hyaluronan Synthases Overexpressing Mesenchymal Stem Cells. [PDF]

Int J Mol Sci, 2020
Hyaluronan (HA), a natural component of the extracellular matrix, is supposed to have a regulatory function in the stem cell niche. Bone marrow-derived human mesenchymal stem cells (hMSCs) are known to express all three hyaluronan synthases (HASes), which are responsible for HA production.
Reiprich S, Hofbauer E, Kiderlen S, Clausen-Schaumann H, Böcker W, Aszódi A, Schönitzer V.   +6 more
europepmc   +6 more sources

Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases [PDF]

Journal of Biological Chemistry, 2007
Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct monosaccharides in different linkages and, in certain cases, participate in polymer transfer out of the cell.
Paul H. Weigel, Paul L. DeAngelis
semanticscholar   +6 more sources

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
doaj   +3 more sources

Expression and molecular characterization of an intriguing hyaluronan synthase (HAS) from the symbiont “Candidatus Mycoplasma liparidae” in snailfish [PDF]

PeerJ
Background Hyaluronan synthases (HASs) are ubiquitous in living organisms, and the hyaluronic acid (HA) synthesized by them are important to their body and well used in medicine, cosmetics and other fields.
Lulu Guo, Shaolu Wang, Chunang Lian, Lisheng He   +3 more
doaj   +4 more sources

Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells. [PDF]

Int J Mol Sci, 2021
During biomineralization, the cells generating the biominerals must be able to sense the external physical stimuli exerted by the growing mineralized tissue and change their intracellular protein composition according to these stimuli. In molluscan shell,
Reiprich S, Akova E, Aszódi A, Schönitzer V.   +3 more
europepmc   +2 more sources

Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. [PDF]

J Clin Med, 2018
Lower extremities varicose veins (VV) are among the most easily recognized venous abnormalities. The genetic mechanism of VV is largely unknown. In this study, we sought to explore the global expressional change of VV and identify novel genes that might ...
Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH.   +6 more
europepmc   +2 more sources