Results 31 to 40 of about 2,278 (170)
Structure, substrate recognition and initiation of hyaluronan synthase [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Finn P. Maloney +9 more
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Quantitative continuous assay for hyaluronan synthase [PDF]
Analytical Biochemistry, 2007 A rapid, continuous, and convenient three-enzyme coupled UV absorption assay was developed to quantitate the glucuronic acid and N-acetylglucosamine transferase activities of hyaluronan synthase from Pasteurella multocida (PmHAS). Activity was measured by coupling the UDP produced from the PmHAS-catalyzed transfer of UDP-GlcNAc and UDP-GlcUA to a ...
Krupa, Joanne C. +6 more
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Frontiers in Pharmacology, 2023 The purpose of this study was to illuminate the mechanism by which Schizonepeta tenuifolia Briq. (ST) ethanolic extract prevents skin photoaging in HR-1 hairless mice (HR-1). The ST ethanolic extract alleviated wrinkle formation, epidermal skin thickness,
Min Ji Gu +9 more
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Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. [PDF]
PLoS ONE, 2010 Hyaluronan (HA) is a glycosaminoglycan located in the interstitial space which is essential for both structural and cell regulatory functions in connective tissue.
Urban Hellman +7 more
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Metabolic control of hyaluronan synthases
Matrix Biology, 2014 Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology of several mammalian tissues.
VIGETTI, DAVIDE +4 more
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Hyaluronan synthase in trabecular meshwork cells [PDF]
British Journal of Ophthalmology, 2003 Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui +8 more
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Hyaluronic acid (hyaluronan): a review
Veterinární Medicína, 2008 Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes.
J. Necas +3 more
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Cosmetics, 2022 Skin aging is a biological process leading to visible skin alterations. The mechanism of action, clinical efficacy and tolerance of a novel anti-wrinkle technology were evaluated in two skin care products formulated for different skin types.
Vinay Bhardwaj +5 more
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Disease Models & Mechanisms, 2019 Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years.
Scott D. Collum +18 more
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Diagnostic usefulness of Hyaluronan & Hyaluronan Synthases-A Review [PDF]
International Journal of Multidisciplinary and Current Research, 2018 The first isolation of HA was in the year 1934, but research on HA and its clinical significance in health and disease started only in the year 1970. Both HA and HASs play a significant role in many physiological and pathological processes. The cellular HA synthesis are coordinated collectively by HASs.
null Dr.Swaminathan.S +3 more
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