Results 31 to 40 of about 2,273 (170)
The Content and Size of Hyaluronan in Biological Fluids and Tissues
Frontiers in Immunology, 2015 Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman +4 more
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Ultraviolet irradiation induces the accumulation of chondroitin sulfate, but not other glycosaminoglycans, in human skin. [PDF]
PLoS ONE, 2011 Ultraviolet (UV) light alters cutaneous structure and function. Prior work has shown loss of dermal hyaluronan after UV-irradiation of human skin, yet UV exposure increases total glycosaminoglycan (GAG) content in mouse models.
Benjamin Boegel Werth +3 more
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Hyaluronan Synthase: New Directions for Hyaluronan Research.
Trends in Glycoscience and Glycotechnology, 1998 今日、ヒアルロン酸は脊椎動物の様々な組織やある種の連鎖球菌の莢膜に広く存在することが知られており、また変形性関節症の関節腔内に注入される補充物として医学応用されるなど、その重要性は年々増加している。ヒアルロン酸は特に、胚時期の細胞増殖や運動性の活発化している組織で、細胞外マトリックスの主要な構成成分として存在し、ヒアルロン酸結合分子や細胞表面受容体との相互作用により、細胞の接着、移動、分化をダイナミックに調節する。さらにこの遍在する高分子は形態形成や再生、創傷治癒、癌の浸潤・転移といった多彩な生命現象に関与することが示されている。他方、ヒアルロン酸の生合成機構解明に向けた研究、特にヒアルロン酸合成酵素を単離し同定する試みが、連鎖球菌や動物細胞を材料に過去十年以上にわたって精力的に行われてきた ...
Naoki Itano, Koji Kimata
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Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity
Biomolecules, 2022 Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti-inflammatory and immunomodulatory functions.
Antony Hoarau +2 more
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Chain Gangs: New Aspects of Hyaluronan Metabolism
Biochemistry Research International, 2012 Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
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BMC Cancer, 2018 Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen +5 more
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The role of hyaluronan in renal cell carcinoma
Frontiers in Immunology, 2023 Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival among RCC patients has not improved significantly in the past few years.
Chenchen Jin, Yunfeng Zong
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Structure, substrate recognition and initiation of hyaluronan synthase [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Finn P. Maloney +9 more
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Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
International Journal of Cell Biology, 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix.
Kirsi Rilla, Arto Koistinen
doaj +1 more source
BMC Cancer, 2009 Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis.
Heikkinen Anna-Mari +9 more
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