Results 11 to 20 of about 265,910 (261)

Metabolic control of hyaluronan synthases [PDF]

Matrix Biology, 2014
Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology of several mammalian tissues.
VIGETTI, DAVIDE, VIOLA, MANUELA, KAROUSOU, EVGENIA, DE LUCA, GIANCARLO, PASSI, ALBERTO   +4 more
semanticscholar   +5 more sources

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma. [PDF]

BMC Cancer, 2013
BackgroundHyaluronan is an extracellular matrix glycosaminoglycan involved in invasion, proliferation and metastasis of various types of carcinomas. In many cancers, aberrant hyaluronan expression implicates disease progression and metastatic potential ...
Siiskonen H, Poukka M, Tyynelä-Korhonen K, Sironen R, Pasonen-Seppänen S.   +4 more
europepmc   +3 more sources

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. [PDF]

J Biol Chem, 2015
Background: Co-immunoprecipitation experiments suggest the existence of HAS2-HAS2 and HAS2-HAS3 enzyme complexes. Results: FRET and proximity ligation assays show homo- and heteromeric complexes among all HASs. Conclusion: Like Golgi glycosyltransferases,
Bart G, Vico NO, Hassinen A, Pujol FM, Deen AJ, Ruusala A, Tammi RH, Squire A, Heldin P, Kellokumpu S, Tammi MI.   +10 more
europepmc   +2 more sources

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content

BMC Cancer, 2009
Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis.
Heikkinen Anna-Mari, Hämäläinen Kirsi, Tammi Raija H, Tammi Markku I, Sironen Reijo, Rilla Kirsi, Nykopp Timo K, Komulainen Marja, Kosma Veli-Matti, Anttila Maarit   +9 more
doaj   +2 more sources

HAS2 (hyaluronan synthase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Diogo O. Escudero
openalex   +4 more sources

Mammalian Hyaluronan Synthases [PDF]

IUBMB Life, 2002
AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki Itano, Koji Kimata
openaire   +4 more sources

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +5 more sources

In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila [PDF]

Journal of Biological Chemistry, 2004
Hyaluronan (HA) is a large linear polymer of repeating disaccharides of glucuronic acid and GlcNAc. Although HA is widely distributed in vertebrate animals, it has not been found in invertebrates, including insect species. Insects utilize chitin, a repeating beta-1,4-linked homopolymer of GlcNAc, as a major component of their exoskeleton.
Satomi Takeo, Momoko Fujise, Takuya Akiyama, Hiroko Habuchi, Naoki Itano, Takashi Matsuo, Toshiro Aigaki, Koji Kimata, Hiroshi Nakato   +8 more
openalex   +5 more sources

Topological Organization of the Hyaluronan Synthase fromStreptococcus pyogenes [PDF]

Journal of Biological Chemistry, 2001
Since we first reported (DeAngelis, P. L., Papaconstantinou, J., and Weigel, P. H. (1993) J. Biol. Chem. 268, 19181-19184) the cloning of the hyaluronan (HA) synthase from Streptococcus pyogenes (spHAS), numerous membrane-bound HA synthases have been discovered in both prokaryotes and eukaryotes.
Coy D. Heldermon, Paul L. DeAngelis, Paul H. Weigel   +2 more
openalex   +4 more sources

SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study [PDF]

mBio
We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences
Urban Hellman, Ebba Rosendal, Joakim Lehrstrand, Johan Henriksson, Tove Björsell, Alfred Wennemo, Max Hahn, Björn Österberg, Luiza Dorofte, Emma Nilsson, Mattias N. E. Forsell, Anna Smed-Sörensen, Anna Lange, Mats G. Karlsson, Clas Ahlm, Anders Blomberg, Sara Cajander, Ulf Ahlgren, Alicia Lind, Johan Normark, Anna K. Överby, Annasara Lenman   +21 more
doaj   +2 more sources