Results 11 to 20 of about 2,588 (196)
HAS2 (hyaluronan synthase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Diogo O. Escudero
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In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila [PDF]
Journal of Biological Chemistry, 2004 Hyaluronan (HA) is a large linear polymer of repeating disaccharides of glucuronic acid and GlcNAc. Although HA is widely distributed in vertebrate animals, it has not been found in invertebrates, including insect species. Insects utilize chitin, a repeating beta-1,4-linked homopolymer of GlcNAc, as a major component of their exoskeleton.
Satomi Takeo +8 more
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Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled
Biologics, 2023 Hyaluronan is one of the major components of the extracellular matrix and is involved in the regulation of multiple processes in both human physiology and disease.
Theodoros Karalis
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Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss [PDF]
Clinical and Experimental Otorhinolaryngology, 2022 Objectives Hyaluronan synthase 1 (HAS1) is a membrane-bound protein that is abundant in the epidermis and dermis, and it is important for skin function. However, its association with hearing loss has not yet been studied.
Alphonse Umugire +5 more
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Adhesive Properties of the Hyaluronan Pericellular Coat in Hyaluronan Synthases Overexpressing Mesenchymal Stem Cells. [PDF]
Int J Mol Sci, 2020 Hyaluronan (HA), a natural component of the extracellular matrix, is supposed to have a regulatory function in the stem cell niche. Bone marrow-derived human mesenchymal stem cells (hMSCs) are known to express all three hyaluronan synthases (HASes), which are responsible for HA production.
Reiprich S +6 more
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Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases [PDF]
Journal of Biological Chemistry, 2007 Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct monosaccharides in different linkages and, in certain cases, participate in polymer transfer out of the cell.
Paul H. Weigel, Paul L. DeAngelis
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Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]
PLoS Pathogens, 2009 In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama +11 more
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Mammalian Hyaluronan Synthases [PDF]
IUBMB Life, 2002 AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki Itano, Koji Kimata
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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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Diagnostic usefulness of Hyaluronan and Hyaluronan Synthases-A Review [PDF]
International Journal of Multidisciplinary and Current Research, 2018 The first isolation of HA was in the year 1934, but research on HA and its clinical significance in health and disease started only in the year 1970. Both HA and HASs play a significant role in many physiological and pathological processes. The cellular HA synthesis are coordinated collectively by HASs.
Dr.Oviya Senthilraj +3 more
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