Hyaluronan Synthase: New Directions for Hyaluronan Research.
Trends in Glycoscience and Glycotechnology, 1998 今日、ヒアルロン酸は脊椎動物の様々な組織やある種の連鎖球菌の莢膜に広く存在することが知られており、また変形性関節症の関節腔内に注入される補充物として医学応用されるなど、その重要性は年々増加している。ヒアルロン酸は特に、胚時期の細胞増殖や運動性の活発化している組織で、細胞外マトリックスの主要な構成成分として存在し、ヒアルロン酸結合分子や細胞表面受容体との相互作用により、細胞の接着、移動、分化をダイナミックに調節する。さらにこの遍在する高分子は形態形成や再生、創傷治癒、癌の浸潤・転移といった多彩な生命現象に関与することが示されている。他方、ヒアルロン酸の生合成機構解明に向けた研究、特にヒアルロン酸合成酵素を単離し同定する試みが、連鎖球菌や動物細胞を材料に過去十年以上にわたって精力的に行われてきた ...
Naoki Itano, Koji Kimata
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Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation [PDF]
Journal of Biological Chemistry, 2005 We report the identification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate as HASNT (for HA synthase 2 antisense) in human and mouse. HASNT is transcribed from the opposite strand of the HAS2 gene locus and is represented by several independent expressed sequence tags in human.
Hsu‐Wen Chao, Andrew P. Spicer
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Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]
BMC Cancer, 2010 Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan ...
Kosma Veli-Matti +8 more
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Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 [PDF]
Advanced Materials, 2019 AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme ...
Huimin Li, Chang Lei, Wei Fang
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Role of hyaluronan in endometrial receptivity: key insights for implantation and reproductive success [PDF]
Reproductive Biology and EndocrinologyInfertility affects millions worldwide, and implantation failure remains a critical barrier in assisted reproduction. Endometrial receptivity, a fundamental prerequisite for successful implantation, involves precise regulation of extracellular matrix ...
Eva Krivakova +6 more
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SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study [PDF]
mBioWe previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences
Urban Hellman +21 more
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Interleukin-1 Beta Mediated Regulation of Hyaluronan and Hyaluronan Synthase 2
, 2005 VCU Theses and ...
Ashley E. Ducale
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Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. [PDF]
J Biol Chem, 2015 Bart G +10 more
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Targeting Hyaluronan Synthesis in Cancer: A Road Less Travelled
Biologics, 2023 Hyaluronan is one of the major components of the extracellular matrix and is involved in the regulation of multiple processes in both human physiology and disease.
Theodoros Karalis
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