Results 21 to 30 of about 5,143 (259)

Hyaluronan Synthase 1: A Novel Candidate Gene Associated With Late-Onset Non-syndromic Hereditary Hearing Loss [PDF]

Clinical and Experimental Otorhinolaryngology, 2022
Objectives Hyaluronan synthase 1 (HAS1) is a membrane-bound protein that is abundant in the epidermis and dermis, and it is important for skin function. However, its association with hearing loss has not yet been studied.
Alphonse Umugire, Sungsu Lee, Chang-Joon Lee, Youngmi Choi, Taekyoung Kim, Hyong-Ho Cho   +5 more
doaj   +1 more source

Mammalian Hyaluronan Synthases [PDF]

IUBMB Life, 2002
AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki, Itano, Koji, Kimata
openaire   +2 more sources

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +1 more source

Hyaluronan: Metabolism and Function

Biomolecules, 2020
As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi, Theerawut Chanmee, Naoki Itano   +2 more
doaj   +1 more source

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Reproductive Biology and Endocrinology, 2022
Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang, Long Bai, Yi-Min Zhu, Peter C. K. Leung   +3 more
doaj   +1 more source

The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer

Journal of Cancer Research and Clinical Oncology, 2022
Purpose Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis.
Jette Riecks, Arianna Parnigoni, Balázs Győrffy, Ludwig Kiesel, Alberto Passi, Davide Vigetti, Martin Götte   +6 more
doaj   +1 more source

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj   +1 more source

PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines [PDF]

, 2015
Hyaluronan (HA) is the major glycosaminoglycan component of the extracellular matrix in either normal or malignant tissues and it may affect proliferation, motility and differentiation of various cell types.
Gergely, Pál, Hajdú, Tibor, Juhász, Tamás, Katona, Éva, Kókai, Endre, Rácz, Kálmán, Somogyi, Csilla, Szász, Csaba, Zákány, Róza   +8 more
core   +4 more sources

Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors

Heliyon, 2023
Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1,
Xunxia Bao, Juan Ran, Chuifang Kong, Zunxi Wan, Juling Wang, Tengfei Yu, Shengming Ruan, Wenjing Ding, Leiming Xia, Daoxiang Zhang   +9 more
doaj   +1 more source

Bacillus subtilis Fermentation Augments the Anti-Inflammatory and Skin Moisture Improvement Activities of Tetragonia tetragonoides through the Upregulation of Antioxidant Components

Fermentation, 2023
This study demonstrates that the fermentation of Tetragonia tetragonioides (T. tetragonioides) by Bacillus subtilis (B. subtilis) subsp. spizizenii enhances its antioxidant, anti-inflammatory, and skin-moisturizing activities. Fermented T. tetragonioides
Hyun Kang, Jin-Woo Hwang, Sung-Gyu Lee
doaj   +1 more source