Results 21 to 30 of about 2,588 (196)
Reproductive Biology and Endocrinology, 2022 Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang +3 more
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Journal of Cancer Research and Clinical Oncology, 2022 Purpose Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis.
Jette Riecks +6 more
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Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis
Biochemical and Biophysical Research Communications, 2020 Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblasts and found that TPA and 4-MU have
Kosuke Kasai +7 more
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Structure, substrate recognition and initiation of hyaluronan synthase [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Finn P. Maloney +9 more
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Quantitative continuous assay for hyaluronan synthase [PDF]
Analytical Biochemistry, 2007 A rapid, continuous, and convenient three-enzyme coupled UV absorption assay was developed to quantitate the glucuronic acid and N-acetylglucosamine transferase activities of hyaluronan synthase from Pasteurella multocida (PmHAS). Activity was measured by coupling the UDP produced from the PmHAS-catalyzed transfer of UDP-GlcNAc and UDP-GlcUA to a ...
Lianli Chi +7 more
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Fermentation, 2023 This study demonstrates that the fermentation of Tetragonia tetragonioides (T. tetragonioides) by Bacillus subtilis (B. subtilis) subsp. spizizenii enhances its antioxidant, anti-inflammatory, and skin-moisturizing activities. Fermented T. tetragonioides
Hyun Kang, Jin-Woo Hwang, Sung-Gyu Lee
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An Engineered Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 2004 The Class I hyaluronan synthase (HAS) is a unique glycosyltransferase synthesizing hyaluronan (HA), a polysaccharide composed of GlcUA and GlcNAc, by using one catalytic domain that elongates two different monosaccharides. As for the synthetic mechanism, there are two alternative manners for the sugar elongation process.
Kenji Monde +7 more
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The Content and Size of Hyaluronan in Biological Fluids and Tissues
Frontiers in Immunology, 2015 Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman +4 more
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Ultraviolet irradiation induces the accumulation of chondroitin sulfate, but not other glycosaminoglycans, in human skin. [PDF]
PLoS ONE, 2011 Ultraviolet (UV) light alters cutaneous structure and function. Prior work has shown loss of dermal hyaluronan after UV-irradiation of human skin, yet UV exposure increases total glycosaminoglycan (GAG) content in mouse models.
Benjamin Boegel Werth +3 more
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Metabolic control of hyaluronan synthases
Matrix Biology, 2014 Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology of several mammalian tissues.
VIGETTI, DAVIDE +4 more
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