Results 21 to 30 of about 265,910 (261)

Hyaluronan Biosynthesis by Class I Streptococcal Hyaluronan Synthases Occurs at the Reducing End [PDF]

Journal of Biological Chemistry, 2005
Previous studies reached different conclusions about whether class I hyaluronan synthases (HASs) elongate hyaluronic acid (HA) by addition to the reducing or the nonreducing end. Here we used two strategies to determine the direction of HA synthesis by purified class I HASs from Streptococcus equisimilis and Streptococcus pyogenes.
Christina A. Baron, Valarie L. Tlapak-Simmons, Paul H. Weigel, Dewan Haque, Russell Gotschall, William M. Canfield   +5 more
openaire   +4 more sources

Expression of hyaluronan synthases in articular cartilage

Osteoarthritis and Cartilage, 2000
To investigate the mRNA expression profiles of three mammalian hyaluronan synthases (HAS1, HAS2 and HAS3) in chondrocytes from normal (undiseased) animal cartilage and osteoarthritic human cartilage maintained in experimental culture systems and exposed to catabolic or anabolic stimuli provided by cytokines, growth factors and retinoic acid ...
D. R. R. Hiscock, Bruce Caterson, Carl R. Flannery   +2 more
openaire   +4 more sources

Hyaluronic acid (hyaluronan): a review

Veterinární Medicína, 2008
Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes.
J. Necas, L. Bartosikova, P. Brauner, J. Kolar   +3 more
doaj   +2 more sources

Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis

Biochemical and Biophysical Research Communications, 2020
Hyaluronan synthase 2 (HAS2) is an integral membrane protein composed of multi-membrane-spanning regions and a large intracellular loop (HAS2-loop). We previously examined the effect of phorbol 12-myristate 13-acetate (PMA) and/or 4-methylumbelliferone (4-MU) on the synthesis of hyaluronan (HA) in human skin fibroblasts and found that TPA and 4-MU have
Kosuke Kasai, Yoshiyuki Kuroda, Yutaro Takabuchi, Akihide Nitta, Takashi Kobayashi, Hiroyuki Nozaka, Tomisato Miura, Toshiya Nakamura   +7 more
openalex   +5 more sources

Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7. [PDF]

Glia
Main Points MMP7 is not essential for demyelination and remyelination in the cuprizone model. MMP7‐/‐ mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7‐/‐ mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Gorter RP, Arreguin AJ, Oost W, de Jonge JC, Kampinga HH, Amor S, Colognato H, Baron W.   +7 more
europepmc   +2 more sources

Hyaluronan synthase 2–mediated hyaluronan production mediates Notch1 activation and liver fibrosis [PDF]

Science Translational Medicine, 2019
Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
Yoon Mee Yang, Mazen Noureddin, Cheng Liu, Koichiro Ohashi, So Yeon Kim, Divya Ramnath, Elizabeth E. Powell, Matthew J. Sweet, Yoon Seok Roh, I‐Fang Hsin, Nan Deng, Zhenqiu Liu, Jiurong Liang, Edward Mena, Daniel Shouhed, Robert F. Schwabe, Dianhua Jiang, Shelly C. Lu, Paul W. Noble, Ekihiro Seki   +19 more
openalex   +6 more sources

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model [PDF]

Current Issues in Molecular Biology
Skin radiance is crucial for enhancing facial attractiveness and is negatively affected by factors like hyperpigmentation and aging-related changes. Current treatments often lack comprehensive solutions for improving skin radiance.
Hyeyeon Chun, Hyejin Lee, Jongwook Kim, Hyerin Yeo, Kyongeun Hyung, Dayoung Song, Moonju Kim, Seung-Hyun Jun, Nae-Gyu Kang   +8 more
doaj   +2 more sources

Potential Skin Health Benefits of Abalone By-Products Suggested by Their Effects on MAPKS and PI3K/AKT/NF-kB Signaling Pathways in HDF and HaCaT Cells [PDF]

Foods
Abalone, a marine edible gastropod with nutritional value, is a popular seafood delicacy worldwide, especially in Asia; however, viscera by-products are generally discarded during processing. Therefore, we investigated the skin health benefits of abalone
Eun-A Kim, Nalae Kang, Jun-Ho Heo, Areumi Park, Seong-Yeong Heo, Chang-Ik Ko, Yong-Seok Ahn, Ginnae Ahn, Soo-Jin Heo   +8 more
doaj   +2 more sources

The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. [PDF]

Cytotechnology, 2015
Terazawa S, Nakajima H, Tobita K, Imokawa G.   +3 more
europepmc   +2 more sources

Enzyme variants in biosynthesis and biological assessment of different molecular weight hyaluronan [PDF]

AMB Express
In the present study, low- and high-molecular-weight hyaluronic acids (LMW-HA and HMW-HA) were synthesized in vitro by truncated Streptococcus equisimilis hyaluronan synthases (SeHAS). The enzyme kinetic parameters were determined for each enzyme variant.
Tahereh Ebrahimi, Malihe Keramati, Farnaz Khodabakhsh, Reza Ahangari Cohan   +3 more
doaj   +2 more sources