Results 41 to 50 of about 2,588 (196)
Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. [PDF]
PLoS ONE, 2010 Hyaluronan (HA) is a glycosaminoglycan located in the interstitial space which is essential for both structural and cell regulatory functions in connective tissue.
Urban Hellman +7 more
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Frontiers in Pharmacology, 2023 The purpose of this study was to illuminate the mechanism by which Schizonepeta tenuifolia Briq. (ST) ethanolic extract prevents skin photoaging in HR-1 hairless mice (HR-1). The ST ethanolic extract alleviated wrinkle formation, epidermal skin thickness,
Min Ji Gu +9 more
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Expression of hyaluronan synthases in articular cartilage
Osteoarthritis and Cartilage, 2000 To investigate the mRNA expression profiles of three mammalian hyaluronan synthases (HAS1, HAS2 and HAS3) in chondrocytes from normal (undiseased) animal cartilage and osteoarthritic human cartilage maintained in experimental culture systems and exposed to catabolic or anabolic stimuli provided by cytokines, growth factors and retinoic acid ...
D. R. R. Hiscock +2 more
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Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions [PDF]
Frontiers in Immunology, 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity.
Siiskonen, Hanna +3 more
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A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function [PDF]
International Journal of Molecular Sciences, 2022 Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been considered a major player in regulating cell proliferation and differentiation. However, a previous study reported that depletion of epidermal HA by Streptomyces hyaluronidase (St-HAase) has no ...
Yukiko Ota +4 more
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Hyaluronic acid (hyaluronan): a review
Veterinární Medicína, 2008 Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes.
J. Necas +3 more
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Cosmetics, 2022 Skin aging is a biological process leading to visible skin alterations. The mechanism of action, clinical efficacy and tolerance of a novel anti-wrinkle technology were evaluated in two skin care products formulated for different skin types.
Vinay Bhardwaj +5 more
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Molecular Identification of a Putative Human Hyaluronan Synthase [PDF]
Journal of Biological Chemistry, 1996 To identify the putative mammalian hyaluronan synthase, we cloned a human cDNA that is related to the Streptococcus hyaluronan synthase (HasA) and the Xenopus developmental protein DG42 which has been shown to have chitin synthase activity. The cDNA, for which we propose the name Has2, encodes a novel protein with a predicted molecular mass of 63.6 kDa.
Yu Yamaguchi, Ken Watanabe
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Disease Models & Mechanisms, 2019 Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that predominantly affects male smokers or ex-smokers and it has a mortality rate of 55% and a median survival of 5 years.
Scott D. Collum +18 more
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Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion
Journal of Experimental & Clinical Cancer Research, 2016 Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang +8 more
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