Results 41 to 50 of about 5,143 (259)

The role of hyaluronan in renal cell carcinoma

Frontiers in Immunology, 2023
Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival among RCC patients has not improved significantly in the past few years.
Chenchen Jin, Yunfeng Zong
doaj   +1 more source

Hyaluronan: Biosynthesis and signaling [PDF]

, 2014
Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions ...
De Luca, G., Deleonibus, S., Karousou, E., Passi, A., Vigetti, D., Viola, M.   +5 more
core   +1 more source

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles

International Journal of Cell Biology, 2015
Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix.
Kirsi Rilla, Arto Koistinen
doaj   +1 more source

Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Cancer Cell International, 2021
Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Mingzhu Li, Shengbo Jin, Yang Cao, Jian Xu, Shendong Zhu, Zheng Li   +5 more
doaj   +1 more source

The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc [PDF]

, 2014
Hyaluronan, a macromolecular glycosaminoglycan, is normally synthesized by hyaluronan synthases at the plasma membrane using cytosolic UDP-GlcUA and UDP-GlcNAc substrates and extruding the elongating chain into the extracellular space.
Hanson, R.W., Hart, G.W., Hascall, V.C., Oikari, S., Passi, A., Tammi, M., Tammi, R., Vigetti, D., Wang, A.   +8 more
core   +1 more source

Diagnostic usefulness of Hyaluronan & Hyaluronan Synthases-A Review [PDF]

International Journal of Multidisciplinary and Current Research, 2018
The first isolation of HA was in the year 1934, but research on HA and its clinical significance in health and disease started only in the year 1970. Both HA and HASs play a significant role in many physiological and pathological processes. The cellular HA synthesis are coordinated collectively by HASs.
null Dr.Swaminathan.S, null King David Edward.T, null Abirami.M.J, null Dr. Oviya Senthilraj   +3 more
openaire   +1 more source

Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. [PDF]

PLoS ONE, 2010
Hyaluronan (HA) is a glycosaminoglycan located in the interstitial space which is essential for both structural and cell regulatory functions in connective tissue.
Urban Hellman, Linus Malm, Li-Ping Ma, Göran Larsson, Stellan Mörner, Michael Fu, Anna Engström-Laurent, Anders Waldenström   +7 more
doaj   +1 more source

Protective effect of Schizonepeta tenuifolia Briq. ethanolic extract against UVB-induced skin aging and photodamage in hairless mice

Frontiers in Pharmacology, 2023
The purpose of this study was to illuminate the mechanism by which Schizonepeta tenuifolia Briq. (ST) ethanolic extract prevents skin photoaging in HR-1 hairless mice (HR-1). The ST ethanolic extract alleviated wrinkle formation, epidermal skin thickness,
Min Ji Gu, Min Ji Gu, Hee-Weon Lee, Hee-Weon Lee, Guijae Yoo, Donghwan Kim, In-Wook Choi, Yoonsook Kim, Sang Keun Ha, Sang Keun Ha   +9 more
doaj   +1 more source

A structural and biochemical model of processive chitin synthesis [PDF]

, 2014
Chitin synthases (CHS) produce chitin, an essential component of the fungal cell wall. The molecular mechanism of processive chitin synthesis is not understood, limiting the discovery of new inhibitors of this enzyme class.
Andrew T. Ferenbach, Atkinson, Barny, Bond, Bowen, Cabib, Charnock, Coutinho, D'Haeze, Daan M.F. van Aalten, Debellé, Drew, Gaughran, Helge C. Dorfmueller, Imai, Kamst, Kamst, Kamst, Karnezis, Kathiravan, Källberg, Manoil, Martínez-Rucobo, Masubuchi, Mavingui, Morgan, Nagahashi, Orlean, Rao, Ruiz-Herrera, Semino, Shaw, Streng, Sudoh, Thompson, Uchida, Vladimir S. Borodkin, Xie, Yabe   +38 more
core   +3 more sources

Hyaluronic acid (hyaluronan): a review

Veterinární Medicína, 2008
Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes.
J. Necas, L. Bartosikova, P. Brauner, J. Kolar   +3 more
doaj   +1 more source