Results 71 to 80 of about 49,201 (297)

Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi. [PDF]

, 2011
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable
Michael A. Miles, Acosta , N,, Llewellyn Martin S., Nidia Acosta, Louisa A Messenger, Acosta Nidia, Bhattacharyya Tapan, Carrasco, Hernan J, Yeo, Matthew, Hernan J Carrasco, Bhattacharyya , T,, Miles, Michael A., Llewellyn , MS,, Isabel L. Mauricio, Yeo Matthew, Miles, M.A., Michael D Lewis, Messenger, Louisa A, Yeo, M., Acosta, N., Mauricio, Isabel Larguinho, Matthew Yeo, Patricio Diosque, Llewellyn, Martin S, Martin S Llewellyn, Miles, Michael A, Lewis, M.D., Messenger Louisa A., Diosque, P., Lewis, Michael D, Miles , MA., Carrasco Hernan J., Llewellyn, Martin S., Llewellyn, M.S., Lewis Michael D., Messenger, L.A., Acosta, Nidia, Lewis, Michael D., Carrasco, H.J., Mauricio, I.L., Mauricio, Isabel L., Messenger, Loisa A., Lewis , MD,, Yeo , M,, Michael A Miles, Miles Michael A., Bhattacharyya, Tapan, Louisa A. Messenger, Carrasco , HJ,, Messenger , LA,, Isabel L Mauricio, Bhattacharyya, T., Diosque Patricio, Hernan J. Carrasco, Martin S. Llewellyn, Diosque, Patricio, Michael D. Lewis, Mauricio, Isabel L, Mauricio Isabel L., Diosque , P,, Tapan Bhattacharyya, Carrasco, Hernán J.   +61 more
core   +1 more source

Molecular characterization and expression analysis of SYCP1 and SYCP3 in hybrid fish derived from Megalobrama amblycephala × Culter alburnus

Journal of the World Aquaculture Society
SYCP1 and SYCP3 are essential testis‐specific genes for centromere pairing during meiosis, as well as for spermatogenesis and fertility in male germ cells.
Jia Xu, Yuandong Sun, Chang Wu, Xiaojuan Cui, Yujing Li, Zhongwei Hua, Yifei Zhang   +6 more
doaj   +1 more source

CROSSING RELATIONSHIPS AMONG ANCIENT AND EXPERIMENTAL SUNFLOWER HYBRID LINEAGES [PDF]

Evolution, 2000
Reproductive barrier formation between newly derived hybrid taxa and their parental species represents a major evolutionary hurdle. Here, I examine the development of a sterility barrier during hybrid speciation by examining the fertility of progeny from all combinations of crosses involving three experimentally synthesized sunflower hybrid lineages ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nucleotide polymorphisms in 12 TULV genomes from the common vole hybrid zone between the Central and Eastern evolutionary lineage.

, 2019
Nucleotide polymorphisms in 12 TULV genomes from the common vole hybrid zone between the Central and Eastern evolutionary lineage.
Rainer G. Ulrich (126621), Gerald Heckel (37348), Sabrina Schmidt (2176456), Moritz Saxenhofer (4263502)   +3 more
core   +1 more source

Origin of a cryptic lineage in a threatened reptile through isolation and historical hybridization [PDF]

Heredity, 2016
Identifying phylogenetically distinct lineages and understanding the evolutionary processes by which they have arisen are important goals of phylogeography. This information can also help define conservation units in endangered species. Such analyses are being transformed by the availability of genomic-scale data sets and novel analytical approaches ...
M G, Sovic, A C, Fries, H L, Gibbs
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]

, 1996
Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
A Itano, P Corbella, Itano, A, Kioussis, D, Corbella, P, Salmon, P, D Kioussis, Robey, E, M Tolaini, E Robey, Tolaini, M, P Salmon   +11 more
core   +1 more source

lineage A1/D1 and the non‐aggressive A1/D2 lineage with roots of oilseed rape

, 2023
Verticillium longisporum is a soilborne fungal vascular pathogen of Brassica crops. Three hybrid lineages originating from three independent hybridization events of four haploid Verticillium parents are known. V .
von Tiedemann, Andreas, Andreas von Tiedemann, Marta Vega‐Marin, Vega‐Marin, Marta   +3 more
core   +1 more source

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Nature Communications, 2017
The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II ...
Xiaowen Zhang, Huai-Chin Chiang, Yao Wang, Chi Zhang, Sabrina Smith, Xiayan Zhao, Sreejith J. Nair, Joel Michalek, Ismail Jatoi, Meeghan Lautner, Boyce Oliver, Howard Wang, Anna Petit, Teresa Soler, Joan Brunet, Francesca Mateo, Miguel Angel Pujana, Elizabeth Poggi, Krysta Chaldekas, Claudine Isaacs, Beth N. Peshkin, Oscar Ochoa, Frederic Chedin, Constantine Theoharis, Lu-Zhe Sun, Tyler J. Curiel, Richard Elledge, Victor X. Jin, Yanfen Hu, Rong Li   +29 more
doaj   +1 more source