Results 81 to 90 of about 1,491,122 (300)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Introgressive Hybridization between Anciently Diverged Lineages of Silene (Caryophyllaceae)

PLoS ONE, 2013
Hybridization has played a major role during the evolution of angiosperms, mediating both gene flow between already distinct species and the formation of new species. Newly formed hybrids between distantly related taxa are often sterile. For this reason, interspecific crosses resulting in fertile hybrids have rarely been described to take place after ...
Anna Petri, Bernard E Pfeil, Bengt Oxelman   +2 more
openaire   +4 more sources

Hybrid cells differentiate to hepatic lineage cells and repair oxidative damage [PDF]

Cellular and Molecular Biology Letters, 2010
AbstractHybrid cells derived from stem cells play an important role in organogenesis, tissue regeneration and cancer formation. However, the fate of hybrid cells and their range of function are poorly understood. Fusing stem cells and somatic cells induces somatic cell reprogramming, and the resulting hybrid cells are embryonic stem cell-like cells ...
Xu, Dan, Wang, Feng, Gu, Hongyan, Wang, Jia, Guo, Qinglong, Zhang, Yanli, Wang, Ziyu   +6 more
openaire   +2 more sources

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Phylogeographic analysis reveals multiple origins of the desert shrub Reaumuria songarica in northern Xinjiang, involving homoploid and tetraploid hybrids

Ecology and Evolution
Hybrid speciation plays an important role in species diversification. The establishment of reproductive isolation is crucial for hybrid speciation, and the identification of diverse types of hybrids, particularly homoploid hybrid species, contributes to ...
Xingke Fan, Xia Yan, Chaoju Qian, Ibrahim Awuku, Pengshu Zhao, Yuqiu Liao, Zhijun Li, Xinrong Li, Xiao‐Fei Ma   +8 more
doaj   +1 more source

Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

Cell Reports, 2016
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch.
Yi-Fen Lu, Patrick Cahan, Samantha Ross, Julie Sahalie, Patricia M. Sousa, Brandon K. Hadland, Wenqing Cai, Erik Serrao, Alan N. Engelman, Irwin D. Bernstein, George Q. Daley   +10 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A hybrid Ornstein–Uhlenbeck–Branching framework unifies microbial and pediatric tumor evolution

Frontiers in Oncology
IntroductionPediatric tumors can relapse despite low mutation burdens, suggesting hybrid evolutionary dynamics shaped by stochastic variability and stabilizing forces.
Seung-Hwan Kim
doaj   +1 more source

Lineage-defining mutations contributing to the Colorado Springs variant [A12-A13].

, 2022
Lineage-defining mutations contributing to the Colorado Springs variant [A12-A13].
Christopher R. Gignoux (7852499), Samantha Tisa (13905877), Jesslyn C. Henriksen (13905883), David D. Pollock (9946921), Chloe Barrington (13905880), Kristy R. Crooks (13905886), Douglas P. Wickert (13905898), Erin A. Almand (13905901), Kristen J. Wade (13905874), Joseph W. Rohrer (13905895), Austin T. Almand (13905889), J. Jordan Steel (499663), Olivia S. Rissland (13905904), John C. Sitko (13905892)   +13 more
core   +1 more source

A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science

Advanced Engineering Materials, EarlyView.
We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann, Sarath Menon, Raphael Röske, Johannes Steinhülb, Michael Selzer, Jan Janssen, Tilmann Hickel, Ruth Schwaiger, Jörg Neugebauer   +8 more
wiley   +1 more source