Results 81 to 90 of about 139,280 (294)

Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity

Cell Reports, 2016
Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune-mismatch.
Yi-Fen Lu, Patrick Cahan, Samantha Ross, Julie Sahalie, Patricia M. Sousa, Brandon K. Hadland, Wenqing Cai, Erik Serrao, Alan N. Engelman, Irwin D. Bernstein, George Q. Daley   +10 more
doaj   +1 more source

A Genome-Wide Analysis of Genetic Diversity inTrypanosoma cruzi Intergenic Regions [PDF]

, 2014
Background Trypanosoma cruzi is the causal agent of Chagas Disease. Recently, the genomes of representative strains from two major evolutionary lineages were sequenced, allowing the construction of a detailed genetic diversity map for this important ...
Agüero, Fernan Gonzalo, Panunzi, Leonardo Gabriel   +1 more
core   +3 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Phylogeographic analysis reveals multiple origins of the desert shrub Reaumuria songarica in northern Xinjiang, involving homoploid and tetraploid hybrids

Ecology and Evolution
Hybrid speciation plays an important role in species diversification. The establishment of reproductive isolation is crucial for hybrid speciation, and the identification of diverse types of hybrids, particularly homoploid hybrid species, contributes to ...
Xingke Fan, Xia Yan, Chaoju Qian, Ibrahim Awuku, Pengshu Zhao, Yuqiu Liao, Zhijun Li, Xinrong Li, Xiao‐Fei Ma   +8 more
doaj   +1 more source

The date of interbreeding between Neandertals and modern humans [PDF]

, 2012
Comparisons of DNA sequences between Neandertals and present-day humans have shown that Neandertals share more genetic variants with non-Africans than with Africans.
Li, Heng, Patterson, Nick, Pääbo, Svante, Reich, David, Sankararaman, Sriram   +4 more
core   +5 more sources

Ancient hybridization inCurcuma(Zingiberaceae)—Accelerator or brake in lineage diversifications?

The Plant Journal, 2023
SUMMARYHybridization is a widespread phenomenon in the evolution of plants and exploring its role is crucial to understanding diversification processes of many taxonomic groups. Recently, more attention is focused on the role of ancient hybridization that has repeatedly been shown as triggers of evolutionary radiation, although in some cases, it can ...
Jana Skopalíková, Jana Leong‐Škorničková, Otakar Šída, Mark Newman, Zuzana Chumová, Vojtěch Zeisek, Vlasta Jarolímová, Axel Dalberg Poulsen, Marcos V. Dantas‐Queiroz, Tomáš Fér, Eliška Záveská   +10 more
openaire   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness

Scientific Reports, 2020
Cell–cell fusion is a physiological process that is hijacked during oncogenesis and promotes tumour evolution. The main known impact of cell fusion is to promote the formation of metastatic hybrid cells following fusion between mobile leucocytes and ...
Lucile Delespaul, Caroline Gélabert, Tom Lesluyes, Sophie Le Guellec, Gaëlle Pérot, Laura Leroy, Jessica Baud, Candice Merle, Lydia Lartigue, Frédéric Chibon   +9 more
doaj   +1 more source

The embryonic ontogeny of the gonadal somatic cells in mice and monkeys

Cell Reports, 2021
Summary: In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal ...
Kotaro Sasaki, Akiko Oguchi, Keren Cheng, Yasuhiro Murakawa, Ikuhiro Okamoto, Hiroshi Ohta, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Takuya Yamamoto, Yasunari Seita, Mitinori Saitou   +11 more
doaj   +1 more source

Distinct hybridization modes in wide- and narrow-ranged lineages of Causonis (Vitaceae)

BMC Biology, 2023
Abstract Background Explaining contrasting patterns of distribution between related species is crucial for understanding the dynamics of biodiversity. Despite instances where hybridization and whole genome duplication (WGD) can yield detrimental outcomes, a role in facilitating the expansion of distribution range has ...
Yu, J, Zhao, H, Niu, Y, You, Y, Barrett, RL, Ranaivoson, RM, Rabarijaona, RN, Parmar, G, Yuan, L, Jin, X, Li, P, Li, J, Wen, J, Chen, Z, Lu, L   +14 more
openaire   +4 more sources