Results 51 to 60 of about 922,478 (345)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Predicting Extreme Environmental Values with Hybrid Models: A Perspective Across Air Quality, Wind Energy, and Sensor Networks

Sensors
This Perspective synthesizes recent (2023–2025) progress in predicting extreme environmental values by combining empirical formulations, physics-based simulation outputs, and sensor-network data.
George Efthimiou
doaj   +1 more source

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. [PDF]

, 2012
A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and ...
Belani, Chandra P, Bies, Robert R, Egorin, Merrill J, Ivy, Percy S, Lieberman, Jeffrey A, Manuck, Stephen B, Marder, Stephen R, Muldoon, Matthew F, Pollock, Bruce G, Sale, Mark E, Scher, Howard I, Sherer, Eric A, Solit, David B   +12 more
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Dynamical patterns of EEG connectivity unveil Parkinson’s disease progression: insights from machine learning analysis

Journal of Physics: Complexity
Parkinson’s disease (PD) is a multifactorial neurodegenerative disorder with complex progression. This study aims to analyze electroencephalography (EEG) connectivity patterns to better understand PD progression and stage of the disease using machine ...
Caroline L Alves, Loriz Francisco Sallum, Francisco Aparecido Rodrigues, Thaise G L de O Toutain, Patrícia Maria de Carvalho Aguiar, Michael Moeckel   +5 more
doaj   +1 more source

Linking Bayesian and agent-based models to simulate complex social-ecological systems in semi-arid regions

Frontiers in Environmental Science, 2015
Interdependencies of ecologic, hydrologic, and social systems challenge traditional approaches to natural resource management in semi-arid regions. As a complex social-ecological system, water demands in the Sonoran Desert from agricultural and urban ...
Aloah J Pope, Randy eGimblett
doaj   +1 more source

Electron density retrieval from truncated Radio Occultation GNSS data [PDF]

, 2019
This paper summarizes the definition and validation of two complementary new strategies, to invert incomplete Global Navigation Satellite System Radio-Occultation (RO) ionospheric measurements, such as the ones to be provided by the future EUMETSAT Polar
Cardellach Galí, Estel, Hernández Pajares, Manuel, Lyu, Haixia, Monte Moreno, Enrique   +3 more
core   +2 more sources

Hybrid Models

, 2023
AbstractHybrid models that combine aspects of the Digital OEM and the Digital Equipment Operator are more often the norm than the exception. Nevertheless, differentiating between these two roles can be very helpful for understanding many of the different concepts associated with them.
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Hybrid Methodology Using Machine Learning Techniques and Feature Engineering Applied to Time Series for Medium- and Long-Term Energy Market Price Forecasting

Energies
In the electricity market, the issue of contract negotiation prices between generators/traders and buyers is of particular relevance, as an accurate contract modeling leads to increased financial returns and business sustainability for the various ...
Flávia Pessoa Monteiro, Suzane Monteiro, Carlos Rodrigues, Josivan Reis, Ubiratan Bezerra, Maria Emília Tostes, Frederico A. F. Almeida   +6 more
doaj   +1 more source