Results 71 to 80 of about 88,475 (282)

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Vesicle and reaction-diffusion hybrid modeling with STEPS

Communications Biology
Abstract Vesicles carry out many essential functions within cells through the processes of endocytosis, exocytosis, and passive and active transport. This includes transporting and delivering molecules between different parts of the cell, and storing and releasing neurotransmitters in neurons.
Iain Hepburn, Jules Lallouette, Weiliang Chen, Andrew R. Gallimore, Sarah Y. Nagasawa-Soeda, Erik De Schutter   +5 more
openaire   +4 more sources

A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

Nature Communications, 2017
Extracellular vesicles (EV)-associated RNAs are serum biomarkers potentially exploitable for early cancer diagnosis. Here the authors develop a catalyzed hairpin DNA circuit within a cationic lipid-polymer hybrid nanoparticle that can detect low–level EV-
Jiaming Hu, Yan Sheng, Kwang Joo Kwak, Junfeng Shi, Bohao Yu, L. James Lee   +5 more
doaj   +1 more source

Structure and function of bacterial dynamin-like proteins [PDF]

, 2012
Membrane dynamics are essential for numerous cellular processes in eukaryotic and prokaryotic cells. In eukaryotic cells, membrane fusion and fission are often catalyzed by large GTPases of the dynamin protein family. These proteins couple GTP hydrolysis
Bramkamp, Marc
core   +1 more source

Multiplex Modular Nanorobotic Systems with Catalytic Activity under Magnetic Navigation

Advanced Functional Materials, EarlyView.
We present modular nanorobots composed of a magnetic propulsion module and different extension modules carrying functional activities, assembled via DNA base pairing. The system integrates propulsion, optical tracking, enzymatic catalysis, and cell docking in a programmable manner.
Voichita Mihali, Xinan Huang, Lucie Motyckova, Nicolas Moreno Gomez, Michal Skowicki, Cora‐Ann Schoenenberger, Peer Fischer, Cornelia G. Palivan   +7 more
wiley   +1 more source

Topology and Dynamics of Active Nematic Vesicles

, 2014
Engineering synthetic materials that mimic the remarkable complexity of living organisms is a fundamental challenge in science and technology. We study the spatiotemporal patterns that emerge when an active nematicfilm of microtubules and molecular ...
Bausch, Andreas R., Bowick, Mark J., DeCamp, Stephen J., Dogic, Zvonimir, Giomi, Luca, Keber, Felix C., Loiseau, Etienne, Marchetti, M. Cristina, Sanchez, Tim   +8 more
core   +2 more sources

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

A new method for isolation and purification of fusion-competent inhibitory synaptic vesicles

Current Research in Physiology
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method to ...
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger   +5 more
doaj   +1 more source

Dendrimer Induced Bilayer Disintegration of Hybrid Vesicles

Journal of Oleo Science
Physicochemical investigations on the inclusion of anionic polyamidoaminesuccinamic acid dendrimer, generation 5 (PAMAM-SA, G5) with positively charged hybrid vesicles (HCV), prepared using soylecithin, ion pair amphiphile (IPA), cholesterol and dihexadecyldimethylammonium bromide, were investigated by dynamic light scattering, transmission electron ...
Guha, Pritam, Roy, Biplab, Nahak, Prasant, Karmakar, Gourab, Karak, Atanu, Bykov, Alexey G., Akentiev, Alexander B., Noskov, Boris A., Dutta, Kunal, Ghosh, Chandradipa, Panda, Amiya K.   +10 more
openaire   +3 more sources

Phase Separation and Nanodomain Formation in Hybrid Polymer/Lipid Vesicles [PDF]

ACS Macro Letters, 2015
Hybrid polymer/lipid large unilamellar vesicles (LUVs) were studied by small angle neutron scattering (SANS), time-resolved Förster resonance energy transfer (TR-FRET), and cryo-transmission electron microscopy (cryo-TEM). For the first time in hybrid vesicles, evidence for phase separation at the nanoscale was obtained, leading to the formation of ...
Tuyen Dao, T. P., Fernandes, Fabio, Er-Rafik, Meriem, Salva, Romain, Schmutz, Marc, Brûlet, Annie, Prieto, Manuel, Sandre, Olivier, Le Meins, Jean-François   +8 more
openaire   +3 more sources