Results 71 to 80 of about 936,481 (343)
THE STRATEGY OF HYBRIDITY AND MIMICRY IN ABDELKEBIR KHATIBI'S NOVEL, "THE TATTOOED MEMORY" [PDF]
Ziglôbitha: This study aims to analyze the concepts of hybridity and mimicry in The Tattooed Memory by Abdelkebir Khatibi, drawing on the theoretical framework proposed by Homi Bhabha in his book The Location of Culture. The novel recounts Khatibi's autobiography,
Hadia TEBIB & Farida BOUZIDANI
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Hybridity in Nonprofit Organizations: Organizational Perspectives on Combining Multiple Logics [PDF]
Seeking to better understand how nonprofit organizations (NPOs) manage hybridity, we investigated what distinguishes NPOs that combine multiple logics in productive and unproductive ways.
Jarvis, Lee C. +2 more
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Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Revisiting Colonial Encounters in Maitreyi Devi’s : A Postcolonial Perspective
SAGE OpenThe Indian novelist, Maitreyi Devi’s account of her love story with Romanian novelist, Mircea Eliade came out in 1974 as Na Hanyate in the Bengali language and its English version was titled It Does Not Die in 1976 by the author herself.
H. M. Zahid Iqbal
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
, 2006 The goal of this paper is to analyze the notion of a hybrid space, to explore the necessity of adopting this term as a characteristic of space, and to question whether it is time to move beyond its use. The term, hybrid, originating in biology, describes
O. Pantelidou, I. Yessios
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