Results 81 to 90 of about 936,481 (343)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Hybridités sahariennes : étude du Désert d’Étienne Dinet et Sliman Ben Ibrahim [PDF]

Revue Roumaine d’Etudes Francophones, 2020
At the junction between the literary geography and the analysis of imperialism in literature, this study explores the ways Sahara and its inhabitants are represented in El Fiafi oua el Kifar ou le Désert (1911), a book written by Étienne Dinet and ...
Adrien BODIOT
doaj  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Refiguring Hybridity in Star Trek [PDF]

, 2018
In this thesis, I explore the ways in which the Star Trek franchise posits hybridity. Examining three hybrid characters—Spock and B’Elanna, both half-human, half-alien, and Data, an android—I explore how each character relates to their hybrid identity ...
Gellis, Elizabeth
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cultural Hybridity in Indonesian Contemporary Cinema: A Postcolonial Study on the Film Bumi Manusia

Insaniyat: Journal of Islam and Humanities
Colonialism has profoundly engulfed the cultural, social, and political aspects of Indonesian society. Indigenous people have responded to its legacy by movements, negotiating their identity, and engaging in cultural appropriation.
Yusri Fajar
doaj   +1 more source

Manifestations of Racial Hybridity as Shown in Robert JC Young's Criticism [PDF]

Beni-Suef University International Journal of Humanities and Social Sciences
This research paper sheds the light on the meaning of the term 'Hybridity' according to Young as shown in the OED and during the nineteenth century which is dominated by colonialism.
Asmaa Maghrabi, Shaymaa Sayed Abdel Aatti   +1 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Hybrid inflation

Physical Review D, 1994
Usually inflation ends either by a slow rolling of the inflaton field, which gradually becomes faster and faster, or by a first-order phase transition. We describe a model where inflation ends in a different way, due to a very rapid rolling (`waterfall') of a scalar field $σ$ triggered by another scalar field $ϕ$.
openaire   +3 more sources