Results 101 to 110 of about 544,031 (290)

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. [PDF]

, 2019
Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care.
Carpten, John D, Kaur, Pushpinder, Lang, Julie E, Porras, Tania B, Ring, Alexander   +4 more
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The Phenotypic Performances of Gerbera Local Bali X Rubby Red Hybrids

AGRIVITA Journal of Agricultural Science, 2017
Gerbera is one of important cut flowers in floriculture industries. It can substitute of chrysanthemum. The novelty of cultivar and superiority of characteristic of gerbera are necessary in the floriculture markets.
Kurnia Yuniarto, Ridho Kurniati, Suryawati Suryawati, Rika Meilasari   +3 more
doaj   +1 more source

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S., Edwards, J., Krishnan, S., Witton, C.J.   +3 more
core  

Hybrid Based Selective Genetic Algorithm

International Journal of Engineering Research and Advanced Technology, 2022
Wireless Sensor Network WSN deployment is an active research area. Its goal is to deploy sensors in certain environment efficiently to optimize some evaluation measures. Meta heuristic searching optimization approaches have been proven to be effective in solving WSN deployment problem. They have strong power in exploring
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Genomic-Bioinformatic Analysis of Transcripts Enriched in the Third-Stage Larva of the Parasitic Nematode Ascaris suum [PDF]

, 2008
Differential transcription in Ascaris suum was investigated using a genomic-bioinformatic approach. A cDNA archive enriched for molecules in the infective third-stage larva (L3) of A.
A Brand, A Fire, A Krogh, A Sugimoto, AA Aboobaker, AJ Nisbet, AJ Nisbet, AJ Wolstenholme, Alasdair J. Nisbet, Alex Loukas, B Besier, B Gorgoni, B Sonnichsen, BE Campbell, BJ Datu, C Britton, CC Mello, Cinzia Cantacessi, CQ Huang, Cui-Qin Huang, D Kressler, DL Donald, DP Knox, DP Knox, DR Brooks, DW Crompton, ELL Sonnhammer, F Simmer, FW Douvres, FW Douvres, G Gao, H Nielsen, H Nielsen, HA Tissenbaum, HP Fagerholm, HS Yu, J Bethony, J Kass, J Parkinson, JA Powell- Coffman, Jason Mulvenna, JD Bendtsen, JM Foster, JM Moser, JP Boyle, JS Gilleard, KD Murrell, L Lebioda, M Ashburner, M Blaxter, M Jiang, M Mitreva, MA Andrade, Michael Cappello, MK Islam, Ning Chen, P Geldhof, P Horton, PA Cottee, PA Pilitt, Paul W. Sternberg, PR Boag, R Barstead, RL McNeel, Robin B. Gasser, RS Kamath, RS Kamath, Rui-Qing Lin, S Hashmi, S Moller, S Nikolaou, SK Kim, TR Burglin, V Reinke, W Peng, W Peng, W Zhong, WE Pomroy, Weiwei Zhong, Xing-Quan Zhu, YH Yang   +80 more
core   +6 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source