Results 81 to 90 of about 535,760 (311)

From Individual to Stand Performance in Hybrids: Challenging the Optimal Parental Genetic Distance

Evolutionary Applications
Hybridization, the interbreeding of distinct genotypes, drives evolutionary processes like speciation and adaptation, potentially via phenotypic transgression, where hybrids exhibit novel traits.
Catharina Y. Utami, Cyrille Violle, Denis Vile, Lisa Perrier, François Vasseur   +4 more
doaj   +1 more source

Fuzzy species limits in Mediterranean gorgonians (Cnidaria, Octocorallia): inferences on speciation processes [PDF]

, 2017
The study of the interplay between speciation and hybridization is of primary importance in evolutionary biology. Octocorals are ecologically important species whose shallow phylogenetic relationships often remain to be studied. In the Mediterranean Sea,
Anne Haguenauer, Aurelle, Baker, Beaumont, Bierne, Bierne, Boulay, Brucker, Calderón, Carpine, Concepcion, Costantini, Csilléry, Darriba, Darwin, Didier Aurelle, Excoffier, Faure, Feder, Ferrier-Pagès, Flot, Garrabou, Gori, Gori, Guindon, Hall, Hey, Hey, Hichem M. Kara, Hoegh-Guldberg, Huson, Isabelle D. Pivotto, Isomura, Knowles, Lamya Chaoui, Ledoux, Librado, Marine Malfant, Marti-Puig, Mauatassem B. Masmoudi, Mcfadden, McFadden, McFadden, Márcio A.G. Coelho, Müller, Nei, Nosil, Nur E. Topçu, Pante, Pante, Pey, Pivotto, Prada, Prada, Pratlong, Pratlong, Rieseberg, Rita Castilho, Ronquist, Roux, Roux, Roy, Sanchez, Shearer, Simmons, Sini, Stephens, Stephens, Thomas, Thompson, Tine, Venn, Vollmer, Wegmann, Wirshing   +74 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. [PDF]

, 1993
We have determined the position within the nucleus of homologous sites of the histone gene cluster in Drosophila melanogaster using in situ hybridization and high-resolution, three-dimensional wide field fluorescence microscopy.
Agard, DA, Dernburg, AF, Hiraoka, Y, Parmelee, SJ, Rykowski, MC, Sedat, JW   +5 more
core  

The dynamics of hybrid metabolic-genetic oscillators

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2013
The synthetic construction of intracellular circuits is frequently hindered by a poor knowledge of appropriate kinetics and precise rate parameters. Here, we use generalized modeling (GM) to study the dynamical behavior of topological models of a family of hybrid metabolic-genetic circuits known as “metabolators.” Under mild assumptions on the kinetics,
Reznik, Ed, Kaper, Tasso J., Segre, Daniel   +2 more
openaire   +4 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phylogenomic analyses of all species of swordtail fishes (genus Xiphophorus) show that hybridization preceded speciation

Nature Communications
Hybridization has been recognized to play important roles in evolution, however studies of the genetic consequence are still lagging behind in vertebrates due to the lack of appropriate experimental systems.
Kang Du, Juliana Morena Bonita Ricci, Yuan Lu, Mateo Garcia-Olazabal, Ronald B. Walter, Wesley C. Warren, Tristram O. Dodge, Molly Schumer, Hyun Park, Axel Meyer, Manfred Schartl   +10 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Rapid mapping of chromosomal breakpoints: from blood to BAC in 20 days [PDF]

, 2009
Structural chromosome aberrations and associated segmental or chromosomal aneusomies are major causes of reproductive failure in humans. Despite the fact that carriers of reciprocal balanced translocation often have no other clinical symptoms or ...
Baumgartner, Adolf, Escudero, Tomas, Kwan, Johnson, Lu, Chun-Mei, Munné, Santiago, Wang, Mei, Weier, Heinz-Ulrich G., Weier, Jingly F.   +7 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source