Results 81 to 90 of about 2,430,895 (313)

Hybrid Genetic Algorithms

, 2022
Hybrid optimization methods have known significant interest in recent years and are being growingly used to solve complex problems in science and engineering. For instance, the famous evolutionary Genetic Algorithm can integrate other techniques within its framework to produce a hybrid global algorithm that takes advantages of that combination and ...
openaire   +1 more source

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization [PDF]

, 1993
Comparative genomic in situ hybridization (CGH) provides a new possibility for searching genomes for imbalanced genetic material. Labeled genomic test DNA, prepared from clinical or tumor specimens, is mixed with differently labeled control DNA prepared ...
Speicher, Michael R., Kovacs, Gyula, Cremer, Thomas, Joos, Stefan, Döhner, Hartmut, Lichter, Peter, Robert-Nicoud, Michel, Manoir, Stanislas du, Popp, Susanne, Schröck, Evelin   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

First observation of a reddish-coated Italian Wolf Canis lupus italicus Altobello 1921 in Abruzzo, Lazio and Molise National Park (Carnivora: Canidae)

Natural History Sciences
During an observation in the Giovenco Valley (Abruzzo), an Italian wolf Canis lupus italicus displaying a reddish-orange coat was documented. The individual, a subadult male in good condition, showed typical morphological traits of the subspecies ...
Tania Bascucci, Alice Veronese, Paolo Iannicca, Davide Magnaghi, Samuele Romagnoli   +4 more
doaj   +1 more source

Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains [PDF]

, 2005
Giuntini E, Mengoni A, De Filippo C, et al. Large-scale genetic variation of the symbiosis-required megaplasmid pSymA revealed by comparative genomic analysis of Sinorhizobium meliloti natural strains. BMC Genomics.
Christian R Landry, Landry, Christian R., Duccio Cavalieri, Mengoni Alessio, Giuntini Elisa, Marco Bazzicalupo, Anke Becker, Giuntini, Elisa, Becker Anke, Elisa Giuntini, Nadia Aubin-Horth, Cavalieri, Duccio, Becker, Anke, Cavalieri Duccio, Bazzicalupo, Marco, Bazzicalupo Marco, De Filippo, Carlotta, Landry Christian R, Alessio Mengoni, De Filippo Carlotta, Carlotta De Filippo, Mengoni, Alessio, Aubin-Horth, Nadia, Aubin-Horth Nadia   +23 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

IDENTIFICATION OF GENETIC DEFECTS IN X-LINKED MENTAL RETARDATION [PDF]

, 2010
Backgrounds: X-linked mental retardation (XLMR) has been the focus of MR research because of 40% excess of males with MR. Genetic defects are estimated to account for 50% MR cases.
Fitri, Aditia Retno
core   +1 more source

Contrasting effect of hybridization on genetic differentiation in three rockfish species with similar life history

Evolutionary Applications
Hybridization can provide evolutionary benefits (e.g., population resilience to climate change) through the introduction of adaptive alleles and increase of genetic diversity. Nevertheless, management strategies may be designed based only on the parental
Anita Wray, Eleni Petrou, Krista M. Nichols, Robert Pacunski, Larry LeClair, Kelly S. Andrews, Marty Kardos, Lorenz Hauser   +7 more
doaj   +1 more source

Genetic pollution risk in newts at the far end of the speciation continuum

Global Ecology and Conservation
Invasive species can erase native biodiversity through genetic pollution: the diminishing of native genetic variation via anthropogenic hybridization.
Anagnostis Theodoropoulos, Aziz Avcı, Daniel Fernández-Guiberteau, Albert Ferran, Kurtuluş Olgun, Nazan Üzüm, Salvador Carranza, Ben Wielstra   +7 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source