Results 71 to 80 of about 3,679,444 (316)

Phylogenomic analyses of all species of swordtail fishes (genus Xiphophorus) show that hybridization preceded speciation

Nature Communications
Hybridization has been recognized to play important roles in evolution, however studies of the genetic consequence are still lagging behind in vertebrates due to the lack of appropriate experimental systems.
Kang Du, Juliana Morena Bonita Ricci, Yuan Lu, Mateo Garcia-Olazabal, Ronald B. Walter, Wesley C. Warren, Tristram O. Dodge, Molly Schumer, Hyun Park, Axel Meyer, Manfred Schartl   +10 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Contrasting effect of hybridization on genetic differentiation in three rockfish species with similar life history

Evolutionary Applications
Hybridization can provide evolutionary benefits (e.g., population resilience to climate change) through the introduction of adaptive alleles and increase of genetic diversity. Nevertheless, management strategies may be designed based only on the parental
Anita Wray, Eleni Petrou, Krista M. Nichols, Robert Pacunski, Larry LeClair, Kelly S. Andrews, Marty Kardos, Lorenz Hauser   +7 more
doaj   +1 more source

First observation of a reddish-coated Italian Wolf Canis lupus italicus Altobello 1921 in Abruzzo, Lazio and Molise National Park (Carnivora: Canidae)

Natural History Sciences
During an observation in the Giovenco Valley (Abruzzo), an Italian wolf Canis lupus italicus displaying a reddish-orange coat was documented. The individual, a subadult male in good condition, showed typical morphological traits of the subspecies ...
Tania Bascucci, Alice Veronese, Paolo Iannicca, Davide Magnaghi, Samuele Romagnoli   +4 more
doaj   +1 more source

Hybrid Genetic Algorithms

, 2022
Hybrid optimization methods have known significant interest in recent years and are being growingly used to solve complex problems in science and engineering. For instance, the famous evolutionary Genetic Algorithm can integrate other techniques within its framework to produce a hybrid global algorithm that takes advantages of that combination and ...
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Genetic pollution risk in newts at the far end of the speciation continuum

Global Ecology and Conservation
Invasive species can erase native biodiversity through genetic pollution: the diminishing of native genetic variation via anthropogenic hybridization.
Anagnostis Theodoropoulos, Aziz Avcı, Daniel Fernández-Guiberteau, Albert Ferran, Kurtuluş Olgun, Nazan Üzüm, Salvador Carranza, Ben Wielstra   +7 more
doaj   +1 more source

From hybrids to hermaphrodites in population genetics [PDF]

Genome Biology, 2013
A report on the 46th annual PopGroup conference, Glasgow, UK, December 18-21, 2012.
Verity, R, Marquardt, J, Hatlen, A, Zohren, J   +3 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source