Results 51 to 60 of about 328,565 (318)

The dynamics of hybrid metabolic-genetic oscillators

Chaos: An Interdisciplinary Journal of Nonlinear Science, 2013
The synthetic construction of intracellular circuits is frequently hindered by a poor knowledge of appropriate kinetics and precise rate parameters. Here, we use generalized modeling (GM) to study the dynamical behavior of topological models of a family of hybrid metabolic-genetic circuits known as “metabolators.” Under mild assumptions on the kinetics,
Reznik, Ed, Kaper, Tasso J., Segre, Daniel   +2 more
openaire   +4 more sources

Cryptic diversity and rampant hybridization in annual gentians on the Qinghai-Tibet Plateau revealed by population genomic analysis

Plant Diversity
Understanding the evolutionary and ecological processes involved in population differentiation and speciation provides critical insights into biodiversity formation.
Peng-Cheng Fu, Qiao-Qiao Guo, Di Chang, Qing-Bo Gao, Shan-Shan Sun   +4 more
doaj   +1 more source

Distribution, phylogeography and hybridization between two parapatric sibling ant species of the genus Temnothorax

, 2007
The present-day range distribution of many species has been influenced by re-occuring glacials of the past. By the retreat into different refugia situated in more southerly regions, species were geographically separated and sometimes diverged into ...
Pusch, Katja
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Increased genetic divergence between two closely related fir species in areas of range overlap

, 2014
This research was supported by National Key Project for Basic Research (2014CB954100) and a Royal Society-NSF China International Joint Project award 2010/R4 to R. J. A. and J. Q.
Wang, Jing,, Liu, Jianquan,, Ingvarsson, Par K., Abbott, Richard,, Jing Wang, Wang, Jing, Liu, Jianquan, Jianquan Liu, Ingvarsson, Pär,, Abbott, Richard John, Richard J. Abbott, Abbott, Richard, Pär K. Ingvarsson, Ingvarsson, Pär, Liu, Jian-Quan   +14 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization [PDF]

, 1993
Comparative genomic in situ hybridization (CGH) provides a new possibility for searching genomes for imbalanced genetic material. Labeled genomic test DNA, prepared from clinical or tumor specimens, is mixed with differently labeled control DNA prepared ...
Speicher, Michael R., Kovacs, Gyula, Cremer, Thomas, Joos, Stefan, Döhner, Hartmut, Lichter, Peter, Robert-Nicoud, Michel, Manoir, Stanislas du, Popp, Susanne, Schröck, Evelin   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genomic and transcriptomic alterations following intergeneric hybridization and polyploidization in the Chrysanthemum nankingense×Tanacetum vulgare hybrid and allopolyploid (Asteraceae)

Horticulture Research, 2018
Genome evolution: Complex interactions in the composites Two drivers of plant speciation – hybridization and polyploidization – may interact to cause significant genetic and genomic changes.
Xiangyu Qi, Haibin Wang, Aiping Song, Jiafu Jiang, Sumei Chen, Fadi Chen   +5 more
doaj   +1 more source

Hybrid speciation in a marine mammal: the clymene dolphin (Stenella clymene).

PLoS ONE, 2014
Natural hybridization may result in the exchange of genetic material between divergent lineages and even the formation of new taxa. Many of the Neo-Darwinian architects argued that, particularly for animal clades, natural hybridization was maladaptive ...
Ana R Amaral, Gretchen Lovewell, Maria M Coelho, George Amato, Howard C Rosenbaum   +4 more
doaj   +1 more source