Results 51 to 60 of about 3,679,444 (316)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Ancient hybridization fuels rapid cichlid fish adaptive radiations

Nature Communications, 2017
Understanding why some evolutionary lineages generate exceptionally high species diversity is an important goal in evolutionary biology. Haplochromine cichlid fishes of Africa’s Lake Victoria region encompass >700 diverse species that all evolved in the ...
J. Meier, D. Marques, S. Mwaiko, C. Wagner, L. Excoffier, O. Seehausen   +5 more
semanticscholar   +1 more source

Revealing chromosomal loci and compositional variations in different ploidy lineages of common carp (♀) × blunt snout bream (♂) via in situ hybridization

Aquaculture Reports
Distant hybridization enhances interspecific gene flow, facilitating emergence of novel species and polyploid lineages. However, investigating the genetic evolutionary relationships between distantly hybridized vertebrate offspring of different ploidy ...
Yalan Zhang, Lan Chen, Hanyu Liu, Yi Fan, Wei Chen, Sijin Fan, Yu Hu, Xinyue Deng, Gaode Zhong, Huan Zhong, Fangzhou Hu, Ming Wen, Wuhui Li, Chang Wu, Qizhi Liu, Shi Wang, Shaojun Liu   +16 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Performance analysis of the partial use of a local optimization operator on the genetic algorithm for the Travelling Salesman Problem

Business Systems Research, 2012
Background: The Travelling Salesman Problem is an NP-hard problem in combinatorial optimization with a number of practical implications. There are many heuristic algorithms and exact methods for solving the problem. Objectives: In this paper we study the
Milan Djordjevic, Marko Grgurovic, Andrej Brodnik   +2 more
doaj  

Hybridization among three native North American Canis species in a region of natural sympatry. [PDF]

PLoS ONE, 2008
Population densities of many species throughout the world are changing due to direct persecution as well as anthropogenic habitat modification. These changes may induce or increase the frequency of hybridization among taxa.
Frank Hailer, Jennifer A Leonard
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Natural and Anthropogenic Hybridization in Two Species of Eastern Brazilian Marmosets (Callithrix jacchus and C. penicillata).

PLoS ONE, 2015
Animal hybridization is well documented, but evolutionary outcomes and conservation priorities often differ for natural and anthropogenic hybrids. Among primates, an order with many endangered species, the two contexts can be hard to disentangle from one
Joanna Malukiewicz, Vanner Boere, Lisieux F Fuzessy, Adriana D Grativol, Ita de Oliveira E Silva, Luiz C M Pereira, Carlos R Ruiz-Miranda, Yuri M Valença, Anne C Stone   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Genetic, morphological, and chemical patterns of plant hybridization

Revista Chilena de Historia Natural, 2014
Natural hybridization is a frequent phenomenon among vascular plants. Hybridization is considered an important evolutionary force since it may lead to (1) an increase of the intraspecific genetic diversity of the participating populations, (2) the ...
A. López-Caamal, E. Tovar-Sánchez
semanticscholar   +1 more source