Results 51 to 60 of about 2,430,895 (313)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hybridization of surface-tethered oligonucleotide brushes [PDF]

, 2009
Part 1. Introduction In this chapter the chemical structures of DNA and oligonucleotides as building materials for subsequent use in biosensor application are described. The general concepts of modern DNA-based biosensors are presented and the commonly
Razumovitch, Julia
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Genomic and transcriptomic alterations following intergeneric hybridization and polyploidization in the Chrysanthemum nankingense×Tanacetum vulgare hybrid and allopolyploid (Asteraceae)

Horticulture Research, 2018
Genome evolution: Complex interactions in the composites Two drivers of plant speciation – hybridization and polyploidization – may interact to cause significant genetic and genomic changes.
Xiangyu Qi, Haibin Wang, Aiping Song, Jiafu Jiang, Sumei Chen, Fadi Chen   +5 more
doaj   +1 more source

Hybrid speciation in a marine mammal: the clymene dolphin (Stenella clymene).

PLoS ONE, 2014
Natural hybridization may result in the exchange of genetic material between divergent lineages and even the formation of new taxa. Many of the Neo-Darwinian architects argued that, particularly for animal clades, natural hybridization was maladaptive ...
Ana R Amaral, Gretchen Lovewell, Maria M Coelho, George Amato, Howard C Rosenbaum   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Performance analysis of the partial use of a local optimization operator on the genetic algorithm for the Travelling Salesman Problem

Business Systems Research, 2012
Background: The Travelling Salesman Problem is an NP-hard problem in combinatorial optimization with a number of practical implications. There are many heuristic algorithms and exact methods for solving the problem. Objectives: In this paper we study the
Milan Djordjevic, Marko Grgurovic, Andrej Brodnik   +2 more
doaj  

Revealing chromosomal loci and compositional variations in different ploidy lineages of common carp (♀) × blunt snout bream (♂) via in situ hybridization

Aquaculture Reports
Distant hybridization enhances interspecific gene flow, facilitating emergence of novel species and polyploid lineages. However, investigating the genetic evolutionary relationships between distantly hybridized vertebrate offspring of different ploidy ...
Yalan Zhang, Lan Chen, Hanyu Liu, Yi Fan, Wei Chen, Sijin Fan, Yu Hu, Xinyue Deng, Gaode Zhong, Huan Zhong, Fangzhou Hu, Ming Wen, Wuhui Li, Chang Wu, Qizhi Liu, Shi Wang, Shaojun Liu   +16 more
doaj   +1 more source