Results 61 to 70 of about 2,551,139 (304)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A genetic analysis of the introgression process from cultivated lettuce (Lactuca sativa L.) to wild prickly lettuce (L. serriola L.) [PDF]
, 2011 Many plant species can hybridise and produce fertile offspring. Hybridization between cultivated species and their wild relatives has raised concerns with regard to GM crops, as it constitutes a possible route along which the transgene could disperse ...
Uwimana, B.
core
Mapping of Multiple DNA Gains and Losses in Primary Small Cell Lung Carcinomas by Comparative Genomic Hybridization [PDF]
, 1994 Comparative genomic hybridization was applied for a comprehensive screening of under- and overrepresentation of genetic material in 13 autoptic small cell lung cancer specimens.
Speicher, Michael R. +6 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization [PDF]
, 1990 A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of ...
Stanyon, Roscoe +3 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
What's in a name; Genetic structure in Solanum section Petota studied using population-genetic tools [PDF]
, 2011 Background - The taxonomy and systematic relationships among species of Solanum section Petota are complicated and the section seems overclassified.
Berg, R.G., van den +7 more
core +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Hybridization of surface-tethered oligonucleotide brushes [PDF]
, 2009 Part 1. Introduction In this chapter the chemical structures of DNA and oligonucleotides as building materials for subsequent use in biosensor application are described. The general concepts of modern DNA-based biosensors are presented and the commonly
Razumovitch, Julia
core +1 more source
Horticulture Research, 2018 Genome evolution: Complex interactions in the composites Two drivers of plant speciation – hybridization and polyploidization – may interact to cause significant genetic and genomic changes.
Xiangyu Qi +5 more
doaj +1 more source