Results 61 to 70 of about 328,565 (318)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Hybridization among three native North American Canis species in a region of natural sympatry. [PDF]

PLoS ONE, 2008
Population densities of many species throughout the world are changing due to direct persecution as well as anthropogenic habitat modification. These changes may induce or increase the frequency of hybridization among taxa.
Frank Hailer, Jennifer A Leonard
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Revealing chromosomal loci and compositional variations in different ploidy lineages of common carp (♀) × blunt snout bream (♂) via in situ hybridization

Aquaculture Reports
Distant hybridization enhances interspecific gene flow, facilitating emergence of novel species and polyploid lineages. However, investigating the genetic evolutionary relationships between distantly hybridized vertebrate offspring of different ploidy ...
Yalan Zhang, Lan Chen, Hanyu Liu, Yi Fan, Wei Chen, Sijin Fan, Yu Hu, Xinyue Deng, Gaode Zhong, Huan Zhong, Fangzhou Hu, Ming Wen, Wuhui Li, Chang Wu, Qizhi Liu, Shi Wang, Shaojun Liu   +16 more
doaj   +1 more source

Suppression-subtractive hybridization as a strategy to identify taxon-specific sequences within the Mycoplasma mycoides Cluster: design and validation of an M. capricolum subsp. capricolum-specific PCR assay [PDF]

, 2008
The phylogenetically related Mycoplasma capricolum subsp. capricolum and M. mycoides subsp. mycoides biotype Large Colony are two small-ruminant pathogens involved in contagious agalactia. Their respective contributions to clinical outbreaks are not well
Maigre, Laure, Poumarat, François, Citti, Christine, Tardy, Florence, Marenda, Marc   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Natural and Anthropogenic Hybridization in Two Species of Eastern Brazilian Marmosets (Callithrix jacchus and C. penicillata).

PLoS ONE, 2015
Animal hybridization is well documented, but evolutionary outcomes and conservation priorities often differ for natural and anthropogenic hybrids. Among primates, an order with many endangered species, the two contexts can be hard to disentangle from one
Joanna Malukiewicz, Vanner Boere, Lisieux F Fuzessy, Adriana D Grativol, Ita de Oliveira E Silva, Luiz C M Pereira, Carlos R Ruiz-Miranda, Yuri M Valença, Anne C Stone   +8 more
doaj   +1 more source

Genetic diversity of Streptococcus suis isolates as determined by comparative genome hybridization

, 2011
Background Streptococcus suis is a zoonotic pathogen that causes infections in young piglets. S. suis is a heterogeneous species. Thirty-three different capsular serotypes have been described, that differ in virulence between as well as within serotypes.
Smith, H.E., Schultsz, C, Baums Christoph G, de Bree, F.M., de Greeff Astrid, Ngo Thi, Hoa, Thi, Hoa Ngo, Christoph G Baums, Thi, HN, Hoa, N.T., Thi Hoa, Bree, F.M., de, Constance Schultsz, Stockhofe-Zurwieden, Norbert, Greeff, A., de, Wisselink Henk J, de Bree, Freddy M., Henk J Wisselink, Hoa Thi, Schultsz, Constance, Smith Hilde E, Hilde E Smith, Baums, Christoph G., Wisselink, H.J., de Bree, FM, Freddy M de Bree, Stockhofe-Zurwieden, N, Stockhofe-Zurwieden, N., Schultsz Constance, Schultsz, C., de Greeff, A, Smith, HE, Baums, CG, de Greeff, Astrid, de Bree Freddy M, de Greeff, A., Baums, C.G., Smith, Hilde E., Stockhofe-Zurwieden Norbert, Wisselink, HJ, Norbert Stockhofe-Zurwieden, Wisselink, Henk J., Astrid de Greeff   +42 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Performance analysis of the partial use of a local optimization operator on the genetic algorithm for the Travelling Salesman Problem

Business Systems Research, 2012
Background: The Travelling Salesman Problem is an NP-hard problem in combinatorial optimization with a number of practical implications. There are many heuristic algorithms and exact methods for solving the problem. Objectives: In this paper we study the
Milan Djordjevic, Marko Grgurovic, Andrej Brodnik   +2 more
doaj