Results 61 to 70 of about 528,870 (180)

Remote Toehold: A Mechanism for Flexible Control of DNA Hybridization Kinetics [PDF]

, 2011
Hybridization of DNA strands can be used to build molecular devices, and control of the kinetics of DNA hybridization is a crucial element in the design and construction of functional and autonomous devices. Toehold-mediated strand displacement
Bath, Jonathan, Genot, Anthony J., Turberfield, Andrew J., Zhang, David Yu   +3 more
core   +1 more source

Detection of monosomy 7 in interphase cells of patients with myeloid disorders [PDF]

, 1990
Six patients, five with acute myeloid leukemia (AML) and one with a myelodysplastic syndrome (MDS), were found to have monosomy 7 by conventional cytogenetics at diagnosis.
Cremer, Thomas, Gezer, Sefer, Kolluri, Rukmini V., Manuelidis, L., Raza, Azra, Sait, Sheila   +5 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Metaheuristic Hybrids

, 2010
Günther R. Raidl is supported by the Austrian Science Fund (FWF) under grants P27615 and W1260.
Raidl, Günther, Puchinger, Jakob, Blum, Christian   +2 more
openaire   +5 more sources

Hybridization of Institutions [PDF]

, 2011
Modal logics are successfully used as specification logics for reactive systems. However, they are not expressive enough to refer to individual states and reason about the local behaviour of such systems. This limitation is overcome in hybrid logics which introduce special symbols for naming states in models.
Martins, Manuel A., Madeira, A., Diaconescu, R., Barbosa, L. S.   +3 more
openaire   +4 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Band-theoretical prediction of magnetic anisotropy in uranium monochalcogenides

, 2000
Magnetic anisotropy of uranium monochalcogenides, US, USe and UTe, is studied by means of fully-relativistic spin-polarized band structure calculations within the local spin-density approximation.
B. Reihl, B. T. Thole, C. Y. Huang, D. L. Tillwick, F. A. Wedgwood, G. H. Lander, H. J. F. Jansen, H. Miyazawa, H. Rudigier, H. Yamagami, J. M. Soler, J. Schoenes, J. Trygg, K. Iwashita, L. Severin, M. Blume, M. S. S. Brooks, P. Carra, P. E. Blöchl, T. Kraft, T. Shishidou, Tamio Oguchi, Tatsuya Shishidou   +22 more
core   +1 more source

SALMON HYBRIDS [PDF]

Science, 1906
n ...
openaire   +2 more sources

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source