Results 71 to 80 of about 538,227 (269)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ning Qing 4: A New Holly Cultivar with Elliptic and Serrated Leaves

HortScience, 2023
Ting Zhou, Xinran Chong, Fan Zhang, Xiaoqing Lu, Donglin Zhang, Hong Chen   +5 more
doaj   +1 more source

Genomic signals of divergence and hybridization between a wild grape (Vitis adenoclada) and domesticated grape ('Shine Muscat')

Fruit Research
Interspecific hybridization in Vitis holds immense potential for combining valuable adaptive traits and breeding superior cultivar development. To evaluate the feasibility of hybrid breeding using the resilient wild species Vitis adenoclada and the ...
Wenjing Peng, Feicui Liang, Zhuyifu Chen, Zhihong Gong, Mengyan Zhang, Rongfu Wei, Hongyan Li, Tianhao Zhang, Fengping Pan, Xiping Yang, Yongfeng Zhou, Zhiyao Ma, Xiaodong Xu, Daidong Wu   +13 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Pod set and Pollen Viability Studies in Yard Long Bean (Vigna unguiculata sub sp. sesquipedalis)

Journal of Horticultural Sciences, 2019
A study was conducted in a yard long bean (Vigna unguiculata sup/ssp. sesquipedalis) hybrid VS 50 (Kakkamoola Local) x VS 26 (Vellayani Jyothika) to assess the percentage fruit set at two time intervals and to identify the best time interval for ...
Merin E G, Sarada S, Celine V A
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Mechanical and Viscoelastic Behavior Characterization of Hybrid Aluminum/Carbon Fiber/Pineapple Leaf Fiber Composite via VARTM for Automotive Industry

Journal of Natural Fibers
Hybridizing natural and synthetic fibers is thought to be an alternate technique for achieving the desired balance between the mechanical performance and sustainability of fiber metal laminates (FMLs). The aluminum (Al)/pineapple leaf fiber (PALF)/carbon
Hanyue Xiao, Mohamed Thariq Hameed Sultan, Farah Syazwani Shahar, Suhas Yeshwant Nayak   +3 more
doaj   +1 more source

Hybrid inflation

Physical Review D, 1994
Usually inflation ends either by a slow rolling of the inflaton field, which gradually becomes faster and faster, or by a first-order phase transition. We describe a model where inflation ends in a different way, due to a very rapid rolling (`waterfall') of a scalar field $σ$ triggered by another scalar field $ϕ$.
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source